Clinical and immunological features of very long-term survivors with a single renal transplant

Transplant International

Volumn 25, Issue 5, 2012, Pages 545-554

  Bererhi, Lynda ^a   Pallet, Nicolas ^a,b   Zuber, Julien ^a,b,c   Anglicheau, Dany ^a,b   Kreis, Henri ^a,b   Legendre, Christophe ^a,b   Candon, Sophie ^a,b,c  

^a ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

immunosuppression; kidney transplantation; renal survival

Indexed keywords

AZATHIOPRINE; CALCINEURIN INHIBITOR; CREATININE; GAMMA INTERFERON; LYMPHOCYTE ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; PROTEIN;

ADULT; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; DYSLIPIDEMIA; EPSTEIN BARR VIRUS; FOLLOW UP; GRAFT REJECTION; GRAFT SURVIVAL; HEPATITIS B; HEPATITIS C; HUMAN; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOSURVEILLANCE; ISCHEMIC HEART DISEASE; KIDNEY GRAFT; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN URINE LEVEL; SKIN CANCER; SOFT TISSUE CANCER; SURVIVAL RATE; SURVIVOR; T LYMPHOCYTE SUBPOPULATION;

ADOLESCENT; ADULT; B-LYMPHOCYTE SUBSETS; COHORT STUDIES; CREATININE; CYTOMEGALOVIRUS; FEMALE; GRAFT SURVIVAL; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOSUPPRESSION; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; NEOPLASMS; PARIS; SURVIVAL RATE; T-LYMPHOCYTE SUBSETS; TIME FACTORS; YOUNG ADULT;

EID: 84859724030     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2012.01451.x     Document Type: Article

References (28)

1. Miyamoto N, Ishida H, Furusawa M, et al. Immunological status in three patients, thirty years after living related renal transplantation: antibody production in long-term survivors. Transpl Immunol 2008; 18: 368.
2. Matas AJ, Gillingham KJ, Humar A, et al. 2202 kidney transplant recipients with 10 years of graft function: what happens next? Am J Transplant 2008; 8: 2410.
3. El-Agroudy AE, Bakr MA, Hassan NA, et al. Characteristics of long-term live-donor renal allograft survivors. Am J Nephrol 2003; 23: 165.
4. Legendre C, Kreis H,. A tribute to Jean Hamburger's contribution to organ transplantation. Am J Transplant 2010; 10: 2392.
5. OPTN. Organ Procurement and Transplantation Network. 2011, Available at:.
6. Legendre CM, Guttmann RD, Hou SK, Jean R,. Two-color immunofluorescence and flow cytometry analysis of lymphocytes in long-term renal allotransplant recipients: identification of a major Leu-7+/Leu-3+ subpopulation. J Immunol 1985; 135: 1061.
7. Focosi D, Bestagno M, Burrone O, Petrini M,. CD57+ T lymphocytes and functional immune deficiency. J Leukoc Biol 2010; 87: 107.
8. Calne RY, Wood AJ,. Cyclosporin in cadaveric renal transplantation: 3-year follow-up of a European multicentre trial. Lancet 1985; 2: 549.
9. El-Zoghby ZM, Stegall MD, Lager DJ, et al. Identifying specific causes of kidney allograft loss. Am J Transplant 2009; 9: 527.
10. Gourishankar S, Leduc R, Connett J, et al. Pathological and clinical characterization of the 'troubled transplant': data from the DeKAF study. Am J Transplant 2010; 10: 324.
11. Matas AJ,. Chronic progressive calcineurin nephrotoxicity: an overstated concept. Am J Transplant 2011; 11: 687.
12. Snanoudj R, Royal V, Elie C, et al. Specificity of histological markers of long-term CNI nephrotoxicity in kidney-transplant recipients under low-dose cyclosporine therapy. Am J Transplant 2011; 11: 2635.
13. Pinto JR, Arellano Torres EM, Franco A, et al. Sirolimus monotherapy as maintenance immunosuppression: a multicenter experience. Transpl Int 2010; 23: 307.
14. Gaya SB, Rees AJ, Lechler RI, Williams G, Mason PD,. Malignant disease in patients with long-term renal transplants. Transplantation 1995; 59: 1705.
15. Slavis SA, Novick AC, Steinmuller DR, et al. Outcome of renal transplantation in patients with a functioning graft for 20 years or more. J Urol 1990; 144: 20.
16. Howard RJ, Patton PR, Reed AI, et al. The changing causes of graft loss and death after kidney transplantation. Transplantation 2002; 73: 1923.
17. O'Donovan P, Perrett CM, Zhang X, et al. Azathioprine and UVA light generate mutagenic oxidative DNA damage. Science 2005; 309: 1871.
18. Fornairon S, Pol S, Legendre C, et al. The long-term virologic and pathologic impact of renal transplantation on chronic hepatitis B virus infection. Transplantation 1996; 62: 297.
19. Legendre C, Garrigue V, Le Bihan C, et al. Harmful long-term impact of hepatitis C virus infection in kidney transplant recipients. Transplantation 1998; 65: 667.
20. Li P, Tian C, Ge N, et al. Premature senescence of T cells in long-term survivors of renal transplantation. Biochem Biophys Res Commun 2011; 407: 599.
21. Velasquez SY, Arias LF, Garcia LF, Alvarez CM,. T cell receptor beta chain (TCR-Vbeta) repertoire of circulating CD4(+) CD25(-), CD4(+) CD25(low) and CD4(+) CD25(high) T cells in patients with long-term renal allograft survival. Transpl Int 2010; 23: 54.
22. Chau LA, Rohekar S, Wang JJ, et al. Thymic re-entry of mature activated T cells and increased negative selection in vascularized allograft recipients. Clin Exp Immunol 2002; 127: 43.
23. Pawelec G, Akbar A, Beverley P, et al. Immunosenescence and Cytomegalovirus: where do we stand after a decade? Immun Ageing 2010; 7: 13.
24. Fulop T, Kotb R, Fortin CF, Pawelec G, de Angelis F, Larbi A,. Potential role of immunosenescence in cancer development. Ann N Y Acad Sci 2010; 1197: 158.
25. Baron C, Forconi C, Lebranchu Y,. Revisiting the effects of CMV on long-term transplant outcome. Curr Opin Organ Transplant 2010; 15: 492.
26. Pawelec G, Derhovanessian E,. Role of CMV in immune senescence. Virus Res 2011; 157: 175.
27. Brouard S, Le Bars A, Dufay A, et al. Identification of a gene expression profile associated with operational tolerance among a selected group of stable kidney transplant patients. Transpl Int 2011; 24: 536.
28. Sagoo P, Perucha E, Sawitzki B, et al. Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest 2010; 120: 1848.