Development of tyrosine-based radiotracer 99mTc-N4-tyrosine for breast cancer imaging

Journal of Biomedicine and Biotechnology

Volumn 2012, Issue , 2012, Pages

  Kong, Fan Lin ^a   Ali, Mohammad S ^a   Rollo, Alex ^a   Smith, Daniel L ^a   Zhang, Yinhan ^a   Yu, Dong Fang ^a   Yang, David J ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18; TECHNETIUM 99M O[3 (1,4,8,11 TETRAAZABICYCLOHEXADECANE)PROPYL]TYROSINE; TRACER; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; DRUG DERIVATIVE; RADIOPHARMACEUTICAL AGENT; SINGLE HETEROCYCLIC RINGS; TECHNETIUM COMPLEX; TECHNETIUM TC 99M CYCLAM; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL; DOSIMETRY; DRUG PURITY; DRUG SYNTHESIS; DRUG TUMOR LEVEL; DRUG UPTAKE; FEMALE; GOLD STANDARD; IN VITRO STUDY; ISOTOPE LABELING; NONHUMAN; RAT; SCINTIGRAPHY; ANIMAL; EXPERIMENTAL NEOPLASM; FISCHER 344 RAT; INFLAMMATION; METABOLISM; RADIATION DOSE; SCINTISCANNING; SYNTHESIS; TISSUE DISTRIBUTION; TUMOR CELL LINE;

RATTUS;

ANIMALS; CELL LINE, TUMOR; FEMALE; FLUORODEOXYGLUCOSE F18; HETEROCYCLIC COMPOUNDS, 1-RING; INFLAMMATION; MAMMARY NEOPLASMS, EXPERIMENTAL; ORGANOTECHNETIUM COMPOUNDS; RADIATION DOSAGE; RADIOACTIVE TRACERS; RADIOPHARMACEUTICALS; RATS; RATS, INBRED F344; TISSUE DISTRIBUTION; TYROSINE;

EID: 84859708310     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2012/671708     Document Type: Article

References (15)

1. Rosenbaum S. J., Lind T., Antoch G., Bockisch A., False-positive FDG PET uptakethe role of PET/CT European Radiology 2006 16 5 1054 1065
2. Jager P. L., Vaalburg W., Pruim J., de Vries E. G., Langen K. J., Piers D. A., Radiolabeled amino acids: basic aspects and clinical applications in oncology Journal of Nuclear Medicine 2001 42 3 432 445 (Pubitemid 32207394)
3. Langen K. J., Hamacher K., Weckesser M., O (2-[ 18 F]fluoroethyl)-L- tyrosine: uptake mechanisms and clinical applications Nuclear Medicine and Biology 2006 33 3 287 294
4. Langen K. J., Pauleit D., Coenen H. H., 3-[ 123 I]Iodo- -methyl-L-tyrosine: uptake mechanisms and clinical applications Nuclear Medicine and Biology 2002 29 6 625 631 (Pubitemid 35266661)
5. Boni R., Steinert H., Huch Boni R., Von Schulthess G. K., Meyer J., Dummer R., Burg G., Westera G., Radioiodine-labelled alpha-methyl-tyrosine in malignant melanoma: cell culture studies and results in patients British Journal of Dermatology 1997 137 1 96 100 (Pubitemid 27305917)
6. Kaira K., Oriuchi N., Otani Y., Shimizu K., Tanaka S., Imai H., Yanagitani N., Sunaga N., Hisada T., Ishizuka T., Dobashi K., Kanai Y., Endou H., Nakajima T., Endo K., Mori M., Fluorine-18- -methyltyrosine positron emission tomography for diagnosis and staging of lung cancer: a clinicopathologic study Clinical Cancer Research 2007 13 21 6369 6378 (Pubitemid 350075026)
7. Tsukada H., Sato K., Fukumoto D., Nishiyama S., Harada N., Kakiuchi T., Evaluation of D-isomers of O - 11 C tyrosine and O - 18 F tyrosine as tumor-imaging agents in tumor-bearing mice: comparison with L- and D- 11 C-methionine Journal of Nuclear Medicine 2006 47 4 679 688 (Pubitemid 46768470)
8. Kole A. C., Nieweg O. E., Pruim J., Standardized uptake value and quantification of metabolism for breast cancer imaging with FDG and L-[1- 11 C]tyrosine PET Journal of Nuclear Medicine 1997 38 5 692 696
9. Jurisson S., Cutler C., Smith S. V., Radiometal complexes: characterization and relevant in vitro studies Quarterly Journal of Nuclear Medicine and Molecular Imaging 2008 52 3 222 234
10. David J., Yang J. L. B., Edmund Kim E., Chelator-based imaging technology: new molecular imaging agents provide answers. Imaging Economics, 2006
11. Anderson C. J., John C. S., Li Y. J., Hancock R. D., McCarthy T. J., Martell A. E., Welch M. J., N, N ′ -Ethylene-di-L-cysteine (EC) complexes of Ga(III) and In(III): molecular modeling, thermodynamic stability and in vivo studies Nuclear Medicine and Biology 1995 22 2 165 173
12. Liu S., Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides Advanced Drug Delivery Reviews 2008 60 12 1347 1370
13. Macey D. J., Williams L. E., Breitz H. B., Liu A., Johnson T. K., Zanzonico P. B., A Primer for Radioimmunotherapy and Radionuclide Therapy 2001
14. Kong F. L., Ali M. S., Zhang Y., Synthesis and evaluation of amino acid-based radiotracer T c 99 m Tc-N4-AMT for breast cancer imaging Journal of Biomedicine and Biotechnology 2011 2011
15. Kong F. L., Zhang Y., Ali M. S., Synthesis of T c 99 m Tc-EC-AMT as an imaging probe for amino acid transporter systems in breast cancer Nuclear Medicine Communications 2010 31 8 699 707