False-positive FDG PET uptake - The role of PET/CT

European Radiology

Volumn 16, Issue 5, 2006, Pages 1054-1065

  Rosenbaum, Sandra J ^a   Lind, Thomas ^a   Antoch, Gerald ^a   Bockisch, Andreas ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

FDG; PET; PET CT; Pitfalls

Indexed keywords

CONTRAST MEDIUM; FLUORODEOXYGLUCOSE F 18; GLUCOSE; METAL; OMEPRAZOLE;

ARTICLE; ARTIFACT; BREATHING MECHANICS; CANCER DIAGNOSIS; CANCER STAGING; CANCER SURGERY; CANCER THERAPY; CANCER TISSUE; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; DIFFERENTIAL DIAGNOSIS; DRUG UPTAKE; GLUCOSE METABOLISM; HUMAN; INFLAMMATION; INTERMETHOD COMPARISON; INTESTINE MOTILITY; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR IMAGING; NUCLEAR MEDICINE; ONCOLOGY; PATIENT MOBILITY; PHYSICIAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIATION ATTENUATION; TISSUE INJURY;

ARTIFACTS; CONTRAST MEDIA; FALSE POSITIVE REACTIONS; FLUORODEOXYGLUCOSE F18; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 33645768397     PISSN: 09387994     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00330-005-0088-y     Document Type: Article

References (44)

1. Avril N (2004) GLUT1 expression in tissue and (18)F-FDG uptake. J Nucl Med 45(6):930-932
2. Hany TF, Gharehpapagh E, Kamel EM, Buck A, Himms-Hagen J, von Schulthess GK (2002) Brown adipose tissue: A factor to consider in symmetrical tracer uptake in the neck and upper chest region. Eur J Nucl Med Mol Imaging 29(10):1393-1398
3. Yeung HW, Grewal RK, Gonen M, Schoder H, Larson SM (2003) Patterns of (18)F-FDG uptake in adipose tissue and muscle: A potential source of false- positives for PET. J Nucl Med 44(11):1789-1796
4. Cohade C, Osman M, Pannu HK, Wahl RL (2003) Uptake in supraclavicular area fat ("USA-Fat"): Description on 18F-FDG PET/CT. J Nucl Med 44(2):170-176
5. Himms-Hagen J (1984) Impaired thermogenesis and brown fat in obesity. Can J Surg 27(2):125
6. Kamel EM, Goerres GW, Burger C, von Schulthess GK, Steinert HC (2002) Recurrent laryngeal nerve palsy in patients with lung cancer: Detection with PET-CT image fusion-report of six cases. Radiology 224(1):153-156
7. Kostakoglu L, Wong JC, Barrington SF, Cronin BF, Dynes AM, Maisey MN (1996) Speech-related visualization of laryngeal muscles with fluorine-18-FDG. J Nucl Med 37(11):1771-1773
8. Fujii H, Ide M, Yasuda S, Takahashi W, Shohtsu A, Kubo A (1999) Increased FDG uptake in the wall of the right atrium in people who participated in a cancer screening program with whole-body PET. Ann Nucl Med 13(1):55-59
9. Yasuda S, Shohtsu A, Ide M, et al (1998) Chronic thyroiditis: Diffuse uptake of FDG at PET. Radiology 207(3):775-778
10. Cohen MS, Arslan N, Dehdashti F, et al (2001) Risk of malignancy in thyroid incidentalomas identified by fluorodeoxyglucose-positron emission tomography. Surgery 130(6):941-946
11. Lerman H, Metser U, Grisaru D, Fishman A, Lievshitz G, Even-Sapir E (2004) Normal and abnormal 18F-FDG endometrial and ovarian uptake in pre- and postmenopausal patients: Assessment by PET/CT. J Nucl Med 45(2):266-271
12. Kosuda S, Fisher S, Kison PV, Wahl RL, Grossman HB (1997) Uptake of 2- deoxy-2-[18F]fluoro-D-glucose in the normal testis: Retrospective PET study and animal experiment. Ann Nucl Med 11(3):195-199
13. Maurea S, Mainolfi C, Bazzicalupo L, et al (1999) Imaging of adrenal tumors using FDG PET: Comparison of benign and malignant lesions. AJR Am J Roentgenol 173(1):25-29
14. Yun M, Kim W, Alnafisi N, Lacorte L, Jang S, Alavi A (2001) 18F-FDG PET in characterizing adrenal lesions detected on CT or MRI. J Nucl Med 42(12):1795-1799
15. Lin EC, Helgans R (2002) Adrenal hyperplasia in Cushing's syndrome demonstrated by FDG positron emission tomographic imaging. Clin Nucl Med 27(7):516-517
16. Shimizu A, Oriuchi N, Tsushima Y, Higuchi T, Aoki J, Endo K (2003) High [18F] 2-fluoro-2-deoxy-D-glucose (FDG) uptake of adrenocortical adenoma showing subclinical Cushing's syndrome. Ann Nucl Med 17(5):403-406
17. Cook GJ, Maisey MN, Fogelman I (1999) Normal variants, artefacts and interpretative pitfalls in PET imaging with 18-fluoro-2-deoxyglucose and carbon-11 methionine. Eur J Nucl Med 26(10):1363-1378
18. Patel PM, Alibazoglu H, Ali A, Fordham E, LaMonica G (1996) Normal thymic uptake of FDG on PET imaging. Clin Nucl Med 21(10):772-775
19. Brink I, Reinhardt MJ, Hoegerle S, Altehoefer C, Moser E, Nitzsche EU (2001) Increased metabolic activity in the thymus gland studied with 18F-FDG PET: Age dependency and frequency after chemotherapy. J Nucl Med 42(4):591-595
20. Liu RS, Yeh SH, Huang MH, et al (1995) Use of fluorine-18 fluorodeoxyglucose positron emission tomography in the detection of thymoma: A preliminary report. Eur J Nucl Med 22(12):1402-1407
21. Tatlidil R, Jadvar H, Bading JR, Conti PS (2002) Incidental colonic fluorodeoxyglucose uptake: Correlation with colonoscopic and histopathologic findings. Radiology 224(3):783-787
22. Delbeke D, Martin WH (2004) PET and PET-CT for evaluation of colorectal carcinoma. Semin Nucl Med 34(3):209-223
23. Denecke T, Rau B, Hoffmann KT, et al (2005) Comparison of CT, MRI and FDG- PET in response prediction of patients with locally advanced rectal cancer after multimodal preoperative therapy: Is there a benefit in using functional imaging? Eur Radiol 15(8):1658-1666
24. Even-Sapir E, Parag Y, Lerman H, et al (2004) Detection of recurrence in patients with rectal cancer: PET/CT after abdominoperineal or anterior resection. Radiology 232(3):815-822
25. Veit P, Antoch G, Stergar H, Bockisch A, Forsting M, Kuehl H (2005) Detection of residual tumor after radiofrequency ablation of liver metastasis with dual- modality PET/CT: Initial results. Eur Radiol 16(1):80-87
26. Cohade C, Osman M, Leal J, Wahl RL (2003) Direct comparison of (18)F-FDG PET and PET/CT in patients with colorectal carcinoma. J Nucl Med 44(11):1797-1803
27. Wahl RL (2004) Why nearly all PET of abdominal and pelvic cancers will be performed as PET/CT. J Nucl Med 45 Suppl 1:82S-95S
28. Chung JH, Cho KJ, Lee SS, et al (2004) Overexpression of Glut1 in lymphoid follicles correlates with false-positive (18)F-FDG PET results in lung cancer staging. J Nucl Med 45(6):999-1003
29. Tomita M, Ichinari H, Tomita Y, et al (2003) A case of non-small cell lung cancer with false-positive staging by positron emission tomography. Ann Thorac Cardiovasc Surg 9(6):397-400
30. Kamel EM, McKee TA, Calcagni ML, et al (2005) Occult lung infarction may induce false interpretation of (18)F-FDG PET in primary staging of pulmonary malignancies. Eur J Nucl Med Mol Imaging Feb 22
31. Shon IH, Fogelman I (2003) F-18 FDG positron emission tomography and benign fractures. Clin Nucl Med 28(3):171-175
32. von Schulthess GK, Meier N, Stumpe KD (2001) Joint accumulations of FDG in whole body PET scans. Nuklearmedizin 40(6):193-197
33. Dehdashti F, Siegel BA, Griffeth LK, et al (1996) Benign versus malignant intraosseous lesions: Discrimination by means of PET with 2-[F-18]fluoro-2- deoxy-D-glucose. Radiology 200(1):243-247
34. Shreve PD, Anzai Y, Wahl RL (1999) Pitfalls in oncologic diagnosis with FDG PET imaging: Physiologic and benign variants. Radiographics 19(1):61-77
35. Sugawara Y, Fisher SJ, Zasadny KR, Kison PV, Baker LH, Wahl RL (1998) Preclinical and clinical studies of bone marrow uptake of fluorine-1-fluorodeoxyglucose with or without granulocyte colony-stimulating factor during chemotherapy. J Clin Oncol 16(1):173-180
36. Antoch G, Freudenberg LS, Beyer T, Bockisch A, Debatin JF (2004) To enhance or not to enhance? 18F-FDG and CT contrast agents in dual- modality 18F-FDG PET/CT. J Nucl Med 45 Suppl 1:56S-65S
37. Antoch G, Freudenberg LS, Egelhof T, et al (2002) Focal tracer uptake: A potential artifact in contrast-enhanced dual-modality PET/CT scans. J Nucl Med 43(10):1339-1342
38. Antoch G, Freudenberg LS, Stattaus J, et al (2002) Whole-body positron emission tomography-CT: Optimized CT using oral and IV contrast materials. AJR Am J Roentgenol 179(6):1555-1560
39. Beyer T, Antoch G, Muller S, et al (2004) Acquisition protocol considerations for combined PET/CT imaging. J Nucl Med 45 Suppl 1:25S-35S
40. Beyer T, Antoch G, Bockisch A, Stattaus J (2005) Optimized intravenous contrast administration for diagnostic whole-body 18F-FDG PET/CT. J Nucl Med 46(3):429-435
41. Kamel EM, Burger C, Buck A, von Schulthess GK, Goerres GW (2003) Impact of metallic dental implants on CT-based attenuation correction in a combined PET/CT scanner. Eur Radiol 13(4):724-728
42. Bockisch A, Beyer T, Antoch G, et al (2004) Positron emission tomography/ computed tomography-imaging protocols, artifacts, and pitfalls. Mol Imaging Biol 6(4):188-199
43. Goerres GW, Kamel E, Heidelberg TN, Schwitter MR, Burger C, von Schulthess GK (2002) PET-CT image co-registration in the thorax: influence of respiration. Eur JNucl Med Mol Imaging 29(3):351-360
44. Osman MM, Cohade C, Nakamoto Y, Wahl RL (2003) Respiratory motion artifacts on PET emission images obtained using CT attenuation correction on PET-CT. Eur J Nucl Med Mol Imaging 30(4):603-606