Possible association of the DRD4 gene with a history of attention-deficit/hyperactivity disorder in women with bulimia nervosa

International Journal of Eating Disorders

Volumn 45, Issue 4, 2012, Pages 622-625

  Yilmaz, Zeynep ^a,b   Kaplan, Allan S ^a,b,c   Levitan, Robert D ^b,c   Zai, Clement C ^b,c   Kennedy, James L ^b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

bulimia nervosa; case control; childhood ADHD; dopamine receptor D4 gene; DRD4 exon III VNTR; family control; pilot data

Indexed keywords

DOPAMINE RECEPTOR; DOPAMINE RECEPTOR D4; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; ATTENTION DEFICIT DISORDER; BULIMIA; CONTROLLED STUDY; EXON; FEMALE; GENE FREQUENCY; GENE TRANSFER; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGENY;

ADOLESCENT; ADULT; ALLELES; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BULIMIA NERVOSA; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D4;

EID: 84859706209     PISSN: 02763478     EISSN: 1098108X     Source Type: Journal    
DOI: 10.1002/eat.20986     Document Type: Article

References (20)

1. Fleming J, Levy L,. Eating disorders in women with AD/HD. In:, Quinn PO, Nadeau KG, editors. Gender Issues and AD/HD: Research, Diagnosis, and Treatment. Silver Spring, MD: Advantage Books, 2002, pp. 411-426.
2. Biederman J, Ball SW, Monuteaux MC, Surman CB, Johnson JL, Zeitlin S,. Are girls with ADHD at risk for eating disorders? Results from a controlled, five-year prospective study. J Dev Behav Pediatr 2007; 28: 302-307.
3. Surman CB, Randall ET, Biederman J,. Association between attention-deficit/hyperactivity disorder and bulimia nervosa: Analysis of 4 case-control studies. J Clin Psychiatry 2006; 67: 351-354.
4. Davis C, Levitan RD, Smith M, Tweed S, Curtis C,. Associations among overeating, overweight, and attention-deficit/hyperactivity disorder: A structural equation modeling approach. Eat Behav 2006; 7: 266-274.
5. Schweickert LA, Strober M, Moskowitz A,. Efficacy of methylphenidate in bulimia nervosa comorbid with attention-deficit hyperactivity disorder: A case report. Int J Eat Disord 1997; 21: 299-301.
6. LaHoste GJ, Swanson JM, Wigal SB, Glabe C, Wigal T, King N, et al. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Mol Psychiatry 1996; 1: 121-124.
7. Gizer IR, Ficks C, Waldman ID,. Candidate gene studies of ADHD: A meta-analytic review. Hum Genet 2009; 126: 51-90.
8. Asghari V, Sanyal S, Buchwaldt S, Paterson A, Jovanovic V, Van Tol HH,. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 1995; 65: 1157-1165.
9. Muglia P, Jain U, Macciardi F, Kennedy JL,. Adult attention deficit hyperactivity disorder and the dopamine D4 receptor gene. Am J Med Genet 2000; 96: 273-277.
10. Kaplan AS, Levitan RD, Yilmaz Z, Davis C, Tharmalingam S, Kennedy JL,. A DRD4/BDNF gene-gene interaction associated with maximum lifetime BMI in women with bulimia nervosa. Int J Eat Disord 2008; 41: 22-28.
11. Levitan RD, Kaplan AS, Davis C, Lam RW, Kennedy JL,. A season-of-birth/DRD4 interaction predicts maximal body mass index in women with bulimia nervosa. Neuropsychopharmacology 2010; 35: 1729-1733.
12. Van Craenenbroeck K, Clark SD, Cox MJ, Oak JN, Liu F, Van Tol HH,. Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis. J Biol Chem 2005; 280: 19350-19357.
13. First MB, Spitzer RL, Gibbon M, Williams JBW,. Structured Clinical Interview for DSM-IV Axis I Disorders, Research VersionâPatient Edition (SCID-I/P). New York: Biometrics Research, New York State Psychiatric Institute, 1995.
14. Fairburn CG, Cooper Z,. The eating disorder examination. In:, Fairburn CG, Wilson GT, editors. Binge Eating: Nature, Assessment and Treatment, 12th ed. New York: The Guilford Press, 1993, pp. 317-331.
15. Ward MF, Wender PH, Reimherr FW,. The Wender Utah Rating Scale: An aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. Am J Psychiatry 1993; 150: 885-890.
16. Lahiri DK, Nurnberger JI Jr,. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 1991; 19: 5444.
17. Hinney A, Schneider J, Ziegler A, Lehmkuhl G, Poustka F, Schmidt MH, et al. No evidence for involvement of polymorphisms of the dopamine D4 receptor gene in anorexia nervosa, underweight, and obesity. Am J Med Genet 1999; 88: 594-597.
18. Ding YC, Chi HC, Grady DL, Morishima A, Kidd JR, Kidd KK, et al. Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proc Natl Acad Sci USA 2002; 99: 309-314.
19. Levitan RD, Masellis M, Lam RW, Kaplan AS, Davis C, Tharmalingam S, et al. A birth-season/DRD4 gene interaction predicts weight gain and obesity in women with seasonal affective disorder: A seasonal thrifty phenotype hypothesis. Neuropsychopharmacology 2006; 31: 2498-2503.
20. Reist C, Ozdemir V, Wang E, Hashemzadeh M, Mee S, Moyzis R,. Novelty seeking and the dopamine D4 receptor gene (DRD4) revisited in Asians: Haplotype characterization and relevance of the 2-repeat allele. Am J Med Genet B: Neuropsychiatr Genet 2007; 144: 453-457.