UVA1 irradiation inhibits fibroblast proliferation and alleviates pathological changes of scleroderma in a mouse model

Journal of Biomedical Research

Volumn 26, Issue 2, 2012, Pages 135-142

  Ju, Mei ^a   Chen, Kun ^a   Chang, Baozhu ^a   Gu, Heng ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Fibroblasts; Mouse model; Proliferation; Scleroderma; Ultraviolet irradiation A1 (UVA1)

Indexed keywords

BLEOMYCIN; COLLAGEN; HYDROXYPROLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FIBROBLAST; IN VITRO STUDY; MONOLAYER CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; SCLERODERMA; SKINFOLD THICKNESS; ULTRAVIOLET A RADIATION; ULTRAVIOLET RADIATION A1;

EID: 84859701500     PISSN: 16748301     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1674-8301(12)60023-2     Document Type: Article

References (30)

1. von Felbert V, Kernland-Lang K, Hoffmann G, Wienert V, Simon D, Hunziker T Irradiation with water-filtered infrared A plus visible light improves cutaneous scleroderma lesions in a series of cases. Dermatology 2011, 222:347-357.
2. Andres C, Kollmar A, Mempel M, Hein R, Ring J, Eberlein B Successful ultraviolet A1 phototherapy in the treatment of localized scleroderma: a retrospective and prospective study. Br J Dermatol 2010, 162:445-447.
3. Rose RF, Turner D, Goodfield MJ, Goulden V Low-dose UVA1 phototherapy for proximal and acral scleroderma in systemic sclerosis. Photodermatol Photoimmunol Photomed 2009, 25:153-155.
4. Ju M, Zhang QS, Zhang XH, Chen K, Chang BZ, Gu H Experimental study on the effect of different dose UVA1 in the treatment of mouse model for scleroderma. Chin J Dermatol (in Chinese) 2009, 42:4-7.
5. Kreuter A, Hyun J, Skrygan M, Sommer A, Bastian A, Altmeyer P, et al. Ultraviolet A1-induced downregulation of human beta-defensins and interleukin-6 and interleukin-8 correlates with clinical improvement in localized scleroderma. Br J Dermatol 2006, 155:600-607.
6. Stege H, Berneburg M, Humke S, Klammer M, Grewe M, Grether-Beck S, et al. High-dose UVA1 radiation therapy for localized scleroderma. J Am Acad Dermatol 1997, 36:938-944.
7. Morita A, Kobayashi K, Isomura I, Tsuji T, Krutmann J Ultraviolet A1 (340-400 nm) phototherapy for scleroderma in systemic sclerosis. J Am Acad Dermatol 2000, 43:670-674.
8. Kerscher M, Volkenandt M, Gruss C, Reuther T, Von Kobyletzki G, Freitag M, et al. Low-dose UVA phototherapy for treatment of localized scleroderma. J Am Acad Dermatol 1998, 38:21-26.
9. Su O, Onsun N, Onay HK, Erdemoglu Y, Ozkaya DB, Cebeci F, et al. Effectiveness of medium-dose ultraviolet A1 phototherapy in localized scleroderma. Int J Dermatol 2011, 50:1006-1013.
10. Sator PG, Radakovic S, Schulmeister K, Hönigsmann H, Tanew A Medium-dose is more effective than low-dose ultraviolet A1 phototherapy for localized scleroderma as shown by 20-MHz ultrasound assessment. J Am Acad Dermatol 2009, 60:786-791.
11. Batteux F, Kavian N, Servettaz A New insights on chemically induced animal models of systemic sclerosis. Curr Opin Rheumatol 2011, 23:511-518.
12. Durand F, Staumont D, Bonnevalle A, Hachulla E, Hatron PY, Thomas P Ultraviolet A1 phototherapy for treatment of acrosclerosis in systemic sclerosis: controlled study with half-side comparison analysis. Photodermatol Photoimmunol Photomed 2007, 23:215-221.
13. Gambichler T, Skrygan T, Tomi NS, Breuksch S, Altmeyer P, Kreuter A Significant downregulation of transforming growth factor-beta signal transducers in human skin following ultraviolet-A1 irradiation. Br J Dermatol 2007, 156:951-956.
14. Gillery P, Serpier H, Polette M, Bellon G, Clavel C, Wegrowski Y, et al. Gamma-interferon inhibits extracellular matrix synthesis and remodeling in coll-agen lattice cultures of normal and scleroderma skin fibroblasts. Eur J Cell Biol 1992, 57:244-253.
15. Trompezinski S, Pernet I, Schmitt D, Viac J UV radiation and prostaglandin E2 up-regulate vascular endothelial growth factor (VEGF) in cultured human fibroblasts. Inflamm Res 2001, 50:422-427.
16. Cao H, Zheng J Application of UVA1 in scleroderma. Int J Dermatol Venereol (in Chinese) 2006, 32:219-221.
17. Besaratinia A, Kim SI, Bates SE, Pfeifer GP Riboflavin activated by ultraviolet A1 irradiation induces oxidative DNA damage-mediated mutations inhibited by vitamin C. Proc Natl Acad Sci USA 2007, 104:5953-5958.
18. Yan SX, Hong XY, Hu Y, Liao KH Tempol, one of nitroxides, is a novel ultraviolet-A1 radiation protector for human dermal fibroblasts. J Dermatol Sci 2005, 37:137-143.
19. Morita A, Krutmann J Ultraviolet A radiation induced apoptosis. Methods Enzymol 2000, 319:302-309.
20. Suh KS, Kang JS, Baek JW, Kim TK, Lee JW, Jeon YS, et al. Efficacy of ultraviolet A1 phototherapy in recalci-trant skin diseases. Ann Dermatol 2010, 22:1-8.
21. Lu Y, Jiang X Effects of ultraviolet on human skin fi-broblasts. Int J Dermatol Venereol (in Chinese) 2006, 32:30-32.
22. Lei XB, Tan SS, Peng ZH Effect of UVA on collagen of fibroblasts' biosynthesis in vitro. Chin J Derm Venereol (in Chinese) 2000, 14:225-226.
23. Nishimori Y, Edwards C, Pearse A, Matsumoto K, Ka-wai M, Marks R Degenerative alterations of dermal collagen fiber bundles in photodamaged human skin and UV-irradiated hairless mouse skin: possible effect on decreasing skin mechanical properties and appearance of wrinkles. J Invest Dermatol 2001, 117:1458-1463.
24. Zhang T, Zheng J Effects of UVA1 on human skin fi-broblasts and clinical application. Chin J Derm Venereol (in Chinese) 2007, 21:567-569.
25. Gruss C, Reed JA, Altmeyer P, McNutt NS, Kerscher M Induction of interstitial collagenase (MMP-1) by UVA-1 phototherapy in morphea fibroblasts. Lancet 1997, 350:1295-1296.
26. Yin L, Yamauchi R, Tsuji MT, Krutmann J, Morita A The expression of matrix metalloproteinase-1 mRNA induced by ultraviolet A1 (340-400 nm) is phototherapy relevant to the glutathione (GSH) content in skin fibroblasts of systemic sclerosis. J Dermatol 2003, 30:173-180.
27. EI-Mofty M, Mostafa W, Esmat S, Youssef R, Bousseila M, Nagi N, et al. Suggested mechanisms of action of UVA in morphea phototherapy: a molecular study. Photodermatol Photoimmunol Photomed 2004, 20:93-100.
28. Yamamoto T, Takagawa S, Katayama I, Yamazaki K, Hamazaki Y, Shinkai H, et al. Animal model of sclerotic skin. I: Local injection of bleomycin induce sclerotic skin mimicking scleroderma. J Invest Dermatol 1999, 112:456-462.
29. Cao H, Zheng J Effects of ultraviolet A1 irradiation on the severity of sclerosis in a mouse model of scleroderma. Chin J Dermatol (in Chinese) 2007, 40:615-618.
30. Zhu LB, Li M Establishment and antibody verification of the animal model of sclerotic skin induced by Bleomycin. Chin J Dermatol (in Chinese) 2003, 36:496-498.