Apigenin, a plant-derived flavone, activates transient receptor potential vanilloid 4 cation channel

British Journal of Pharmacology

Volumn 166, Issue 1, 2012, Pages 349-358

  Ma, Xin ^a   He, Dongxu ^a   Ru, Xiaochen ^b   Chen, Yun ^a   Cai, Yanfei ^a   Bruce, Iain C ^b   Xia, Qiang ^b   Yao, Xiaoqiang ^a,c   Jin, Jian ^a  

^a JIANGNAN UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

apigenin; endothelial cell; TRPV4; vasodilatation

Indexed keywords

APIGENIN; CALCIUM; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG MECHANISM; FLUORESCENCE IMAGING; GENE OVEREXPRESSION; GENE SEQUENCE; HYPERPOLARIZATION; ISOLATED ARTERY; MALE; MESENTERIC ARTERY; MYOGRAPHY; NONHUMAN; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PRIMARY CELL CULTURE; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER MEMBRANE; WHOLE CELL;

ANIMALS; APIGENIN; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HEK293 CELLS; HUMANS; MALE; MESENTERIC ARTERIES; MUSCLE, SMOOTH, VASCULAR; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; TRPV CATION CHANNELS; VASODILATION;

EID: 84859701223     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01767.x     Document Type: Article

References (46)

1. Alvarez-Castro E, Campos-Toimil M, Orallo F, (2004). (-)- Epigallocatechin-3-gallate induces contraction of the rat aorta by a calcium influx-dependent mechanism. Naunyn Schmiedebergs Arch Pharmacol 369: 496-506.
2. Arniges M, Vazquez E, Fernandez-Fernandez JM, Valverde MA, (2004). Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia. J Biol Chem 279: 54062-54068.
3. Campos-Toimil M, Orallo F, (2007). Effects of (-)-epigallocatechin-3- gallate in Ca2+ -permeable non-selective cation channels and voltage-operated Ca2+ channels in vascular smooth muscle cells. Life Sci 80: 2147-2153.
4. Capasso A, Pinto A, Sorrentino R, Capasso F, (1991). Inhibitory effects of quercetin and other flavonoids on electrically-induced contractions of guinea pig isolated ileum. J Ethnopharmacol 34: 279-281.
5. Cassidy A, O'Reilly EJ, Kay C, Sampson L, Franz M, Forman JP, et al,. (2011). Habitual intake of flavonoid subclasses and incident hypertension in adults. Am J Clin Nutr 93: 338-347.
6. Everaerts W, Zhen X, Ghosh D, Vriens J, Gevaert T, Gilbert JP, et al,. (2010). Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci U S A 107: 19084-19089.
7. Feletou M, Vanhoutte PM, (2006). Endothelium-derived hyperpolarizing factor: where are we now? Arterioscler Thromb Vasc Biol 26: 1215-1225.
8. Figtree GA, Griffiths H, Lu YQ, Webb CM, MacLeod K, Collins P, (2000). Plant-derived estrogens relax coronary arteries in vitro by a calcium antagonistic mechanism. J Am Coll Cardiol 35: 1977-1985.
9. Fotsis T, Pepper MS, Aktas E, Breit S, Rasku S, Adlercreutz H, et al,. (1997). Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Res 57: 2916-2921.
10. Fusi F, Saponara S, Frosini M, Gorelli B, Sgaragli G, (2003a). L-type Ca2+ channels activation and contraction elicited by myricetin on vascular smooth muscles. Naunyn Schmiedebergs Arch Pharmacol 368: 470-478.
11. Fusi F, Saponara S, Pessina F, Gorelli B, Sgaragli G, (2003b). Effects of quercetin and rutin on vascular preparations: a comparison between mechanical and electrophysiological phenomena. Eur J Nutr 42: 10-17.
12. Fusi F, Sgaragli G, Saponara S, (2005). Mechanism of myricetin stimulation of vascular L-type Ca2+ current. J Pharmacol Exp Ther 313: 790-797.
13. Gerritsen ME, Carley WW, Ranges GE, Shen CP, Phan SA, Ligon GF, et al,. (1995). Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression. Am J Pathol 147: 278-292.
14. Ghayur MN, Khan H, Gilani AH, (2007). Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid. Arch Pharm Res 30: 970-975.
15. Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D, (1993). Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342: 1007-1011.
16. Huang Y, Zhang A, Lau CW, Chen ZY, (1998). Vasorelaxant effects of purified green tea epicatechin derivatives in rat mesenteric artery. Life Sci 63: 275-283.
17. Illek B, Lizarzaburu ME, Lee V, Nantz MH, Kurth MJ, Fischer H, (2000). Structural determinants for activation and block of CFTR-mediated chloride currents by apigenin. Am J Physiol Cell Physiol 279: C1838-C1846.
18. Keli SO, Hertog MG, Feskens EJ, Kromhout D, (1996). Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch Intern Med 156: 637-642.
19. Kim HJ, Yum KS, Sung JH, Rhie DJ, Kim MJ, Min DS, et al,. (2004). Epigallocatechin-3-gallate increases intracellular [Ca2+] in U87 cells mainly by influx of extracellular Ca2+ and partly by release of intracellular stores. Naunyn Schmiedebergs Arch Pharmacol 369: 260-267.
20. Kohler R, Heyken WT, Heinau P, Schubert R, Si H, Kacik M, et al,. (2006). Evidence for a functional role of endothelial transient receptor potential V4 in shear stress-induced vasodilatation. Arterioscler Thromb Vasc Biol 26: 1495-1502.
21. Kottgen M, Buchholz B, Garcia-Gonzalez MA, Kotsis F, Fu X, Doerken M, et al,. (2008). TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol 182: 437-447.
22. Kwan HY, Huang Y, Yao X, (2004). Regulation of canonical transient receptor potential isoform 3 (TRPC3) channel by protein kinase G. Proc Natl Acad Sci U S A 101: 2625-2630.
23. Liu C, Ngai CY, Huang Y, Ko WH, Wu M, He GW, et al,. (2006). Depletion of intracellular Ca2+ stores enhances flow-induced vascular dilatation in rat small mesenteric artery. Br J Pharmacol 147: 506-515.
24. Loizzo MR, Said A, Tundis R, Rashed K, Statti GA, Hufner A, et al,. (2007). Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae). Phytother Res 21: 32-36.
25. Loot AE, Popp R, Fisslthaler B, Vriens J, Nilius B, Fleming I, (2008). Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation. Cardiovasc Res 80: 445-452.
26. Ma X, Cao J, Luo J, Nilius B, Huang Y, Ambudkar IS, et al,. (2010a). Depletion of intracellular Ca2+ stores stimulates the translocation of vanilloid transient receptor potential 4-c1 heteromeric channels to the plasma membrane. Arterioscler Thromb Vasc Biol 30: 2249-2255.
27. Ma X, Qiu S, Luo J, Ma Y, Ngai CY, Shen B, et al,. (2010b). Functional role of vanilloid transient receptor potential 4-canonical transient receptor potential 1 complex in flow-induced Ca2+ influx. Arterioscler Thromb Vasc Biol 30: 851-858.
28. - cotransporter in renal epithelial A6 cells by flavonoids: genistein, daidzein, and apigenin. Biochem Biophys Res Commun 254: 368-371.
29. Nilius B, Droogmans G, (2001). Ion channels and their functional role in vascular endothelium. Physiol Rev 81: 1415-1459.
30. Nilius B, Watanabe H, Vriens J, (2003). The TRPV4 channel: structure-function relationship and promiscuous gating behaviour. Pflugers Arch 446: 298-303.
31. Nilius B, Vriens J, Prenen J, Droogmans G, Voets T, (2004). TRPV4 calcium entry channel: a paradigm for gating diversity. Am J Physiol Cell Physiol 286: C195-C205.
32. Olszanecki R, Gebska A, Kozlovski VI, Gryglewski RJ, (2002). Flavonoids and nitric oxide synthase. J Physiol Pharmacol 53: 571-584.
33. Pan Z, Feng T, Shan L, Cai B, Chu W, Niu H, et al,. (2008a). Scutellarin-induced endothelium-independent relaxation in rat aorta. Phytother Res 22: 1428-1433.
34. Pan Z, Yang H, Mergler S, Liu H, Tachado SD, Zhang F, et al,. (2008b). Dependence of regulatory volume decrease on transient receptor potential vanilloid 4 (TRPV4) expression in human corneal epithelial cells. Cell Calcium 44: 374-385.
35. Plant TD, Strotmann R, (2007). TRPV4. Handb Exp Pharmacol 179: 189-205.
36. Saponara S, Sgaragli G, Fusi F, (2002). Quercetin as a novel activator of L-type Ca(2+) channels in rat tail artery smooth muscle cells. Br J Pharmacol 135: 1819-1827.
37. Saponara S, Sgaragli G, Fusi F, (2008). Quercetin antagonism of Bay K 8644 effects on rat tail artery L-type Ca(2+) channels. Eur J Pharmacol 598: 75-80.
38. Vincent F, Acevedo A, Nguyen MT, Dourado M, DeFalco J, Gustafson A, et al,. (2009). Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun 389: 490-494.
39. Voets T, Prenen J, Vriens J, Watanabe H, Janssens A, Wissenbach U, et al,. (2002). Molecular determinants of permeation through the cation channel TRPV4. J Biol Chem 277: 33704-33710.
40. Vriens J, Watanabe H, Janssens A, Droogmans G, Voets T, Nilius B, (2004). Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci U S A 101: 396-401.
41. Vriens J, Owsianik G, Fisslthaler B, Suzuki M, Janssens A, Voets T, et al,. (2005). Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. Circ Res 97: 908-915.
42. Watanabe H, Davis JB, Smart D, Jerman JC, Smith GD, Hayes P, et al,. (2002). Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem 277: 13569-13577.
43. Watanabe H, Vriens J, Janssens A, Wondergem R, Droogmans G, Nilius B, (2003). Modulation of TRPV4 gating by intra- and extracellular Ca2+. Cell Calcium 33: 489-495.
44. Wijetunge S, Aalkjaer C, Schachter M, Hughes AD, (1992). Tyrosine kinase inhibitors block calcium channel currents in vascular smooth muscle cells. Biochem Biophys Res Commun 189: 1620-1623.
45. Wong CO, Huang Y, Yao X, (2010). Genistein potentiates activity of the cation channel TRPC5 independently of tyrosine kinases. Br J Pharmacol 159: 1486-1496.
46. Wu L, Gao X, Brown RC, Heller S, O'Neil RG, (2007). Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells. Am J Physiol Renal Physiol 293: F1699-F1713.