Partners in crime: VEGF and IL-4 conscript tumour-promoting macrophages

Journal of Pathology

Volumn 227, Issue 1, 2012, Pages 4-7

  De Palma, Michele ^a,b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b EPFL   (Switzerland)

Author keywords

Angiogenesis; IL 4; TAM reprogramming; Tumour associated macrophages (TAMs); VEGF A

Indexed keywords

INTERLEUKIN 4; VASCULOTROPIN;

ANGIOGENESIS; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; HUMAN; MACROPHAGE ACTIVATION; PERIPHERAL CIRCULATION; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH;

ANIMALS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MACROPHAGES; SKIN NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84859652232     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4008     Document Type: Review

References (24)

1. Chung AS, Ferrara N. Developmental and pathological angiogenesis. Annu Rev Cell Dev Biol 2011; 27: 563-584.
2. Tugues S, Koch S, Gualandi L, et al. Vascular endothelial growth factors and receptors: anti-angiogenic therapy in the treatment of cancer. Mol Aspects Med 2011; 32: 88-111.
3. Potente M, Gerhardt H, Carmeliet P. Basic and therapeutic aspects of angiogenesis. Cell 2011; 146: 873-887.
4. Weis SM, Cheresh DA. Tumour angiogenesis: molecular pathways and therapeutic targets. Nature Med 2011; 17: 1359-1370.
5. Leite de Oliveira R, Hamm A, Mazzone M. Growing tumour vessels: more than one way to skin a cat - implications for angiogenesis targeted cancer therapies. Mol Aspects Med 2011; 32: 71-87.
6. Sawano A, Iwai S, Sakurai Y, et al. Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans. Blood 2001; 97: 785-791. (Pubitemid 32113414)
7. Grunewald M, Avraham I, Dor Y, et al. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 2006; 124: 175-189. (Pubitemid 43069318)
8. Kerber M, Reiss Y, Wickersheim A, et al. Flt-1 signaling in macrophages promotes glioma growth in vivo. Cancer Res 2008; 68: 7342-7351.
9. Squadrito ML, De Palma M. Macrophage regulation of tumour angiogenesis: implications for cancer therapy. Mol Aspects Med 2011; 32: 123-145.
10. Ziegler-Heitbrock L, Ancuta P, Crowe S, et al. Nomenclature of monocytes and dendritic cells in blood. Blood 2010; 116: e74-e80.
11. Laoui D, Van Overmeire E, Movahedi K, et al. Mononuclear phagocyte heterogeneity in cancer: different subsets and activation states reaching out at the tumour site. Immunobiology 2011; 216: 1192-1202.
12. Linde N, Lederle W, Depner S, et al. Vascular endothelial growth factor induced skin carcinogenesis depends on recruitment and alternative activation of macrophages. J Pathol 2012; DOI: 10.1002/path. 3989.
13. Lederle W, Linde N, Heusel J, et al. Platelet-derived growth factor-B normalizes micromorphology and vessel function in vascular endothelial growth factor-A-induced squamous cell carcinomas. Am J Pathol 2010; 176: 981-994.
14. Murdoch C, Muthana M, Coffelt SB, et al. The role of myeloid cells in the promotion of tumour angiogenesis. Nature Rev Cancer 2008; 8: 618-631.
15. Qian BZ, Pollard JW. Macrophage diversity enhances tumour progression and metastasis. Cell 2010; 141: 39-51.
16. Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nature Immunol 2010; 11: 889-896.
17. Pucci F, Venneri MA, Biziato D, et al. A distinguishing gene signature shared by tumour-infiltrating Tie2-expressing monocytes, blood 'resident' monocytes, and embryonic macrophages suggests common functions and developmental relationships. Blood 2009; 114: 901-914.
18. Stein M, Keshav S, Harris N, et al. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med 1992; 176: 287-292.
19. Ferrara N. Role of myeloid cells in vascular endothelial growth factor-independent tumour angiogenesis. Curr Opin Hematol 2010; 17: 219-224.
20. + T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumour properties of macrophages. Cancer Cell 2009; 16: 91-102.
21. Jenkins SJ, Ruckerl D, Cook PC, et al. Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science 2011; 332: 1284-1288.
22. De Palma M, Mazzieri R, Politi LS, et al. Tumour-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumour growth and metastasis. Cancer Cell 2008; 14: 299-311.
23. Rolny C, Mazzone M, Tugues S, et al. HRG inhibits tumour growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. Cancer Cell 2011; 19: 31-44.
24. Beatty GL, Chiorean EG, Fishman MP, et al. CD40 agonists alter tumour stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 2011; 331: 1612-1616.