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Volumn 22, Issue 2, 2012, Pages 161-165

Computational fluid dynamics (CFD) and direct visualization studies of aerosol release from two cyclohaler-type dry powder inhalers

Author keywords

Aerosol dynamics; CFD modeling; Dry powder inhaler; Particle deposition

Indexed keywords

AEROSOL; AIRFLOW; ARTICLE; COMPUTATIONAL FLUID DYNAMICS; CYCLOHALER TYPE DRY POWDER INHALER; DRUG DELIVERY SYSTEM; DRUG RELEASE; FLOW RATE; LOWER RESPIRATORY TRACT; PARTICLE SIZE; POWDER INHALER; VELOCITY; VIDEORECORDING;

EID: 84859646399     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(12)50021-3     Document Type: Article
Times cited : (16)

References (27)
  • 1
    • 47049128164 scopus 로고    scopus 로고
    • Dry powder inhaler (DPIs) - A review of device reliability and innovation
    • Islam N., Gladki E. - Dry powder inhaler (DPIs) - a review of device reliability and innovation. - Int. J. Pharm., 360, 1-11, 2008.
    • (2008) Int. J. Pharm. , vol.360 , pp. 1-11
    • Islam, N.1    Gladki, E.2
  • 2
    • 85031182956 scopus 로고    scopus 로고
    • Preparations for inhalation: Aerodynamic assessment of fine particles
    • Council of Europe, Strasbourg
    • European Pharmacopoeia 5.0. - Preparations for inhalation: aerodynamic assessment of fine particles. - Council of Europe, Strasbourg, 2005, p. 244-253.
    • (2005) European Pharmacopoeia 5.0 , pp. 244-253
  • 3
    • 33745284283 scopus 로고    scopus 로고
    • Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma
    • Buhl R. - Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma. - Allergy, 61, 518-526, 2006.
    • (2006) Allergy , vol.61 , pp. 518-526
    • Buhl, R.1
  • 4
    • 85031180502 scopus 로고    scopus 로고
    • CFD modeling as a tool in evaluation and development of inhalation devices
    • Abstracts of EAC 2004
    • Moskal A., Sosnowski T.R., Gradon L. - CFD modeling as a tool in evaluation and development of inhalation devices. - J. Aerosol Sci., Abstracts of EAC 2004, Vol.1, S623-S624, 2004.
    • (2004) J. Aerosol Sci. , vol.1
    • Moskal, A.1    Sosnowski, T.R.2    Gradon, L.3
  • 5
    • 8644282632 scopus 로고    scopus 로고
    • Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1: Grid structure and mouthpiece length
    • DOI 10.1002/jps.20201
    • Coates M.S., Fletcher D.F., Chan H.K., Raper J.A. - Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1. Grid structure and mouthpiece length. - J. Pharm. Sci., 93, 2863-2876, 2004. (Pubitemid 39506635)
    • (2004) Journal of Pharmaceutical Sciences , vol.93 , Issue.11 , pp. 2863-2876
    • Coates, M.S.1    Fletcher, D.F.2    Chan, H.-K.3    Raper, J.A.4
  • 6
    • 33745056503 scopus 로고    scopus 로고
    • Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2: Air inlet size
    • DOI 10.1002/jps.20603
    • Coates M.S., Chan H.K., Fletcher D.F., Raper J.A. - Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2. Air inlet size. - J. Pharm. Sci., 95, 1382-1392, 2006. (Pubitemid 43874452)
    • (2006) Journal of Pharmaceutical Sciences , vol.95 , Issue.6 , pp. 1382-1392
    • Coates, M.S.1    Chan, H.-K.2    Fletcher, D.F.3    Raper, J.A.4
  • 7
    • 84859639616 scopus 로고    scopus 로고
    • Estimation of aggregates break-up conditions in the model resuspension chamber
    • R.N. Dalby Ed., Davis Healthcare Int. Publ. LLC, River Grove
    • Moskal A., Sosnowski T.R. - Estimation of aggregates break-up conditions in the model resuspension chamber. - In: Respiratory Drug Delivery 2008, R.N. Dalby Ed., Davis Healthcare Int. Publ. LLC, River Grove, 2008, p. 969-972.
    • (2008) Respiratory Drug Delivery 2008 , pp. 969-972
    • Moskal, A.1    Sosnowski, T.R.2
  • 8
    • 33846230643 scopus 로고    scopus 로고
    • Mechanims of aerosol particle deposition in the oro-pharynx under non-steady airflow
    • DOI 10.1093/annhyg/mel072
    • Sosnowski T.R., Moskal A., Gradon L. - Mechanims of aerosol particle deposition in the oro-pharynx under non-steady airflow. - Ann. Occup. Hyg., 51, 19-25, 2007. (Pubitemid 46096392)
    • (2007) Annals of Occupational Hygiene , vol.51 , Issue.1 , pp. 19-25
    • Sosnowski, T.R.1    Moskal, A.2    Gradon, L.3
  • 9
    • 73949092864 scopus 로고    scopus 로고
    • Dynamics of aerosol pulse in a simplified mouth-throat geometry and its significance for inhalation drug delivery
    • Moskal A. Sosnowski TR. - Dynamics of aerosol pulse in a simplified mouth-throat geometry and its significance for inhalation drug delivery. - Chem. Process Eng., 30, 545-558, 2009.
    • (2009) Chem. Process Eng. , vol.30 , pp. 545-558
    • Moskal, A.1    Sosnowski, T.R.2
  • 10
    • 0036845924 scopus 로고    scopus 로고
    • Temporary and spatial deposition of aerosol particles in the upper human airways during breathing cycle
    • DOI 10.1016/S0021-8502(02)00108-8, PII S0021850202001088
    • Moskal A., Gradon L. - Temporary and spatial deposition of aerosol particles in the upper human airways during breathing cycle. - J. Aerosol Sci., 33, 1525-1539, 2002. (Pubitemid 35300481)
    • (2002) Journal of Aerosol Science , vol.33 , Issue.11 , pp. 1525-1539
    • Moskal, A.1    Gradon, L.2
  • 11
    • 84859634834 scopus 로고    scopus 로고
    • Powder inhaler
    • European Patent Application PCT/PL2005/000059, 8 September
    • Gradon L., Sosnowski T.R., Moskal A. - Powder inhaler. - European Patent Application PCT/PL2005/000059, 8 September 2005.
    • (2005)
    • Gradon, L.1    Sosnowski, T.R.2    Moskal, A.3
  • 12
    • 8644282632 scopus 로고    scopus 로고
    • Turbulent flow energy for design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1. Grid structure and mouthpiece length
    • Gac J., Sosnowski T.R., Gradon L. - Turbulent flow energy for design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1. Grid structure and mouthpiece length. - J. Pharm. Sci., 93, 2863-2876, 2004.
    • (2004) J. Pharm. Sci. , vol.93 , pp. 2863-2876
    • Gac, J.1    Sosnowski, T.R.2    Gradon, L.3
  • 13
    • 77954313947 scopus 로고    scopus 로고
    • Modification of inhalable powders by pulmonary surfactant components adsorbed on droplets during spray-drying process
    • Sosnowski T.R., Gradon L.- Modification of inhalable powders by pulmonary surfactant components adsorbed on droplets during spray-drying process. - Colloids and Surfaces A: Physicochem. Eng. Aspects, 365, 56-61, 2010.
    • (2010) Colloids and Surfaces A: Physicochem. Eng. Aspects , vol.365 , pp. 56-61
    • Sosnowski, T.R.1    Gradon, L.2
  • 15
    • 0037855989 scopus 로고    scopus 로고
    • Computational fluid dynamics simulation of airflow and aerosol deposition in human lungs
    • Nowak N., Kakade P.P., Annapragada A.V. - Computational fluid dynamics simulation of airflow and aerosol deposition in human lungs. - Ann. Biomed. Eng., 31, 374-390, 2003.
    • (2003) Ann. Biomed. Eng. , vol.31 , pp. 374-390
    • Nowak, N.1    Kakade, P.P.2    Annapragada, A.V.3
  • 16
    • 12344301305 scopus 로고    scopus 로고
    • Comparison of micro- and nano-size particle depositions in a human upper airway model
    • DOI 10.1016/j.jaerosci.2004.08.006, PII S0021850204003325
    • Zhang Z., Kleinstreuer C., Donohue J.F., Kim C.S. - Comparison of micro- and nano-size particle depositions in a human upper airway model. - J. Aerosol Sci., 36, 211-233, 2005. (Pubitemid 40138840)
    • (2005) Journal of Aerosol Science , vol.36 , Issue.2 , pp. 211-233
    • Zhang, Z.1    Kleinstreuer, C.2    Donohue, J.F.3    Kim, C.S.4
  • 18
    • 67549098260 scopus 로고    scopus 로고
    • Evaluation of the Respimat soft mist inhaler using a concurrent CFD and in vitro approach
    • Longest P.W., Hindle M. - Evaluation of the Respimat soft mist inhaler using a concurrent CFD and in vitro approach. - J. Aerosol Med., 22, 99-112, 2009.
    • (2009) J. Aerosol Med. , vol.22 , pp. 99-112
    • Longest, P.W.1    Hindle, M.2
  • 19
    • 84859650657 scopus 로고    scopus 로고
    • Numerical simulation of in vitro dispersion and deposition of nanoparticles in dry-powder-inhaler aerosols
    • Mendes P.J., Pinto J.F., Sousa J.M.M. - Numerical simulation of in vitro dispersion and deposition of nanoparticles in dry-powder-inhaler aerosols. - J. Nanosci. Nanotechn., 9, 1-7, 2009.
    • (2009) J. Nanosci. Nanotechn. , vol.9 , pp. 1-7
    • Mendes, P.J.1    Pinto, J.F.2    Sousa, J.M.M.3
  • 20
    • 77953613719 scopus 로고    scopus 로고
    • Particle aerosolisation and break-up in dry powder inhalers. 1. Evaluation and modelling of Venturi effects for agglomerated systems
    • Wong W., Fletcher D.F., Traini D., Chan H.-K., Crapper J., Young P.M.- Particle aerosolisation and break-up in dry powder inhalers. 1. Evaluation and modelling of Venturi effects for agglomerated systems. - Pharm. Res., 27, 1367-1376, 2010.
    • (2010) Pharm. Res. , vol.27 , pp. 1367-1376
    • Wong, W.1    Fletcher, D.F.2    Traini, D.3    Chan, H.-K.4    Crapper, J.5    Young, P.M.6
  • 21
    • 79953248684 scopus 로고    scopus 로고
    • Deposition of fractal-like soot aggregates in the human respiratory tract
    • Broday D.M., Rosenzweig R. - Deposition of fractal-like soot aggregates in the human respiratory tract. - J. Aerosol Sci., 42, 372-386, 2011.
    • (2011) J. Aerosol Sci. , vol.42 , pp. 372-386
    • Broday, D.M.1    Rosenzweig, R.2
  • 22
    • 0030884080 scopus 로고    scopus 로고
    • Flow-dependent effect of formoterol dry-powder inhaled from the Aerolizer
    • DOI 10.1183/09031936.97.10092105
    • Nielsen K.G., Skov M., Klug B., Ifversen M., Bisgaard H. - Flow-dependent effect of formoterol dry-powder inhaled from the Aerolizer. - Eur. Respir. J., 10, 2105-2109, 1997. (Pubitemid 27406450)
    • (1997) European Respiratory Journal , vol.10 , Issue.9 , pp. 2105-2109
    • Nielsen, K.G.1    Skov, M.2    Klug, B.3    Ifversen, M.4    Bisgaard, H.5
  • 23
    • 0029347552 scopus 로고
    • Computer simulation of particle deposition in the upper tracheobronchial tree
    • Li A., Ahmadi G. - Computer simulation of particle deposition in the upper tracheobronchial tree. - Aerosol Sci. Techn., 23, 201-223, 1995.
    • (1995) Aerosol Sci. Techn. , vol.23 , pp. 201-223
    • Li, A.1    Ahmadi, G.2
  • 24
    • 0142245108 scopus 로고    scopus 로고
    • Centerra Resource Park, Lebanon
    • Fluent 6.1. - User's Guide. - Centerra Resource Park, Lebanon, 2003.
    • (2003) Fluent 6.1. - User's Guide
  • 25
    • 33745261802 scopus 로고    scopus 로고
    • Dynamics of oropharyngeal aerosol transport and deposition with the realistic flow pattern
    • Sosnowski T.R., Moskal A., Gradon L. - Dynamics of oropharyngeal aerosol transport and deposition with the realistic flow pattern. - Inhalation Toxicol., 18, 773-780, 2006.
    • (2006) Inhalation Toxicol. , vol.18 , pp. 773-780
    • Sosnowski, T.R.1    Moskal, A.2    Gradon, L.3
  • 26
    • 0031094542 scopus 로고    scopus 로고
    • Mechanical separation process and flow patterns of cyclone dust collectors
    • Ogawa A. - Mechanical separation process and flow patterns of cyclone dust collectors. - Appl. Mech. Rev., 50, 97-200, 1997.
    • (1997) Appl. Mech. Rev. , vol.50 , pp. 97-200
    • Ogawa, A.1
  • 27
    • 0028086190 scopus 로고
    • Critical aspects of the function of inspiratory flow driven inhalers
    • Olsson B., Asking L. - Critical aspects of the function of inspiratory flow driven inhalers. - J. Aerosol Med., 7 (S1), S43-S47, 1994.
    • (1994) J. Aerosol Med. , vol.7 , Issue.S1
    • Olsson, B.1    Asking, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.