Effect of haemodilution, acidosis, and hypothermia on the activity of recombinant factor VIIa (NovoSeven®)

British Journal of Anaesthesia

Volumn 101, Issue 3, 2008, Pages 324-331

  Viuff, D ^a   Lauritzen, B ^a   Pusateri, A E ^b   Andersen, S ^a   Rojkjaer, R ^b   Johansson, P I ^c  

^a NOVO NORDISK A S   (Denmark)

^b NOVO NORDISK INC   (United States)

^c Rigshospitalet   (Denmark)

Author keywords

Blood, haemodilution; Complications, acidosis; Hypothermia; Measurement techniques, thromboelastography; rFVIIa; Surgery, haemostatic response

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; ALBUMIN; HETASTARCH; PLASMA SUBSTITUTE; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RINGER LACTATE SOLUTION; SODIUM CHLORIDE; BLOOD CLOTTING FACTOR 7A; HEMOSTATIC AGENT; RECOMBINANT FVIIA; RECOMBINANT PROTEIN;

ACIDOSIS; ANIMAL EXPERIMENT; ARTICLE; BLEEDING TIME; BLOOD CLOT; CONTROLLED STUDY; DRUG ACTIVITY; FEMALE; HEMODILUTION; HEMOSTASIS; HUMAN; HYPOTHERMIA; NONHUMAN; PRIORITY JOURNAL; RABBIT; THROMBOELASTOGRAPHY; ANIMAL; BLOOD; DOSE RESPONSE; DRUG EFFECT; IN VITRO STUDY; MOLECULAR WEIGHT; PH;

ACIDOSIS; ANIMALS; BLEEDING TIME; DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR VIIA; FEMALE; HEMODILUTION; HEMOSTASIS; HEMOSTATICS; HETASTARCH; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOTHERMIA; MOLECULAR WEIGHT; PLASMA SUBSTITUTES; RABBITS; RECOMBINANT PROTEINS; THROMBELASTOGRAPHY;

EID: 50949084274     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aen175     Document Type: Article

References (27)

1. Schortgen F, Deye N, Brochard L. Preferred plasma volume expanders for critically ill patients: results of an international survey. Intensive Care Med 2004; 30: 2222-2229
2. de Jonge E, Levi M. Effects of different plasma substitutes on blood coagulation: a comparative review. Crit Care Med 2001; 29: 1261-1267
3. Janvrin SB, Davies G, Greenhalgh RM. Postoperative deep vein thrombosis caused by intravenous fluids during surgery. Br J Surg 1980; 67: 690-693
4. Ruttmann TG, James MF, Viljoen JF. Haemodilution induces a hypercoagulable state. Br J Anaesth 1996; 76: 412-414
5. Franz A, Braunlich P, Gamsjager T, Felfernig M, Gustorff B, Kozek-Langenecker SA. The effects of hydroxyethyl starches of varying molecular weights on platelet function. Anesth Analg 2001; 92: 1402-1407
6. Jamnicki M, Bombeli T, Seifert B, et al. Low- and medium-molecular- weight hydroxyethyl starches: comparison of their effect on blood coagulation. Anesthesiology 2000; 93: 1231-1237
7. Roche AM, James MF, Bennett-Guerrero E, Mythen MG. A head-to-head comparison of the in vitro coagulation effects of saline-based and balanced electrolyte crystalloid and colloid intravenous fluids. Anesth Analg 2006; 102: 1274-1279
8. von Roten I, Madjdpour C, Frascarolo P, et al. Molar substitution and C2/C6 ratio of hydroxyethyl starch: influence on blood coagulation. Br J Anaesth 2006; 96: 455-463
9. Hoffman M, Monroe DM, III. The action of high-dose factor VIIa (FVIIa) in a cell-based model of haemostasis. Semin Hematol 2001; 38: 6-9
10. Grounds RM, Bolan C. Clinical experiences and current evidence for therapeutic recombinant factor VIIa treatment in nontrauma settings. Crit Care 2005; 9: S29-36
11. Boffard KD, Riou B, Warren B, et al. Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, doubleblind clinical trials. J Trauma 2005; 59: 8-15
12. Dutton RP, McCunn M, Hyder M, et al. Factor VIIa for correction of traumatic coagulopathy. J Trauma 2004; 57: 709-718
13. Martinowitz U, Michaelson M. Guidelines for the use of recombinant activated factor VII (rFVIIa) in uncontrolled bleeding: a report by the Israeli Multidisciplinary rFVIIa Task Force. J Thromb Haemost 2005; 3: 640-648
14. Klemcke HG, Delgado A, Holcomb JB, et al. Effect of recombinant FVIIa in hypothermic, coagulopathic pigs with liver injuries. J Trauma 2005; 59: 155-161
15. Martinowitz U, Holcomb JB, Pusateri AE, et al. Intravenous rFVIIa administered for haemorrhage control in hypothermic coagulopathic swine with grade V liver injuries. J Trauma 2001; 50: 721-729
16. Meng ZH, Wolberg AS, Monroe DM, III, Hoffman M. The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients. J Trauma 2003; 55: 886-891
17. Strauss RG, Pennell BJ, Stump DC. A randomized, blinded trial comparing the haemostatic effects of pentastarch versus hetastarch. Transfusion 2002; 42: 27-36
18. De Lorenzo C, Calatzis A, Welsch U, Heindl B. Fibrinogen concentrate reverses dilutional coagulopathy induced in vitro by saline but not by hydroxyethyl starch 6%. Anesth Analg 2006; 102: 1194-1200
19. Niemi TT, Suojaranta-Ylinen RT, Kukkonen SI, Kuitunen AH. Gelatin and hydroxyethyl starch, but not albumin, impair haemostasis after cardiac surgery. Anesth Analg 2006; 102: 998-1006
20. Nielsen VG. Effects of Hextend hemodilution on plasma coagulation kinetics in the rabbit: role of factor XIII-mediated fibrin polymer crosslinking. J Surg Res 2006; 132: 17-22
21. Martinowitz U, Kenet G, Segal E, et al. Recombinant activated factor VII for adjunctive hemorrhage control in trauma. J Trauma 2001; 51: 431-438
22. O'Neill PA, Bluth M, Gloster ES, et al. Successful use of recombinant activated factor VII for trauma-associated hemorrhage in a patient without preexisting coagulopathy. J Trauma 2002; 52: 400-405
23. Hall K, Forrest P, Sawyer C. The effects of acidosis and hypothermia on blood transfusion requirements following factor VII administration. Anaesth Intensive Care 2007; 35: 494-497
24. Kettner SC, Sitzwohl C, Zimpfer M, et al. The effect of graded hypothermia (36 degrees C-32 degrees C) on hemostasis in anesthetized patients without surgical trauma. Anesth Analg 2003; 96: 1772-1776, table
25. Kheirabadi BS, Delgado AV, Dubick MA, et al. In vitro effect of activated recombinant factor VII (rFVIIa) on coagulation properties of human blood at hypothermic temperatures. J Trauma 2007; 63: 1079-1086
26. Pusateri A, Delgado A, Martini W, Uscilowicz J, Christensen S. Effects of acidosis and hypothermia on whole blood clotting function in swine. J Thromb Haemost 2005; 3: 1402
27. Jones SB, Whitten CW, Despotis GJ, Monk TG. The influence of crystalloid and colloid replacement so-lutions in acute normovolemic hemodilution: a preliminary survey of hemostatic markers. Anesth Analg 2003; 96: 363-368, table