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Clinical results of long-term follow-up of a large, active surveillance cohort with localized prostate cancer
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This study is the largest prospective series available in the literature providing level 1 evidence of long-term oncological outcomes of active surveillance in patients with localized prostate cancer
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Klotz L, Zhang L, Lam A, et al. Clinical results of long-term follow-up of a large, active surveillance cohort with localized prostate cancer. J Clin Oncol 2010; 28:126-131. This study is the largest prospective series available in the literature providing level 1 evidence of long-term oncological outcomes of active surveillance in patients with localized prostate cancer.
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[Epub ahead of print]. doi: 10.1111/j.1464-410X.2011.10612.x The study shows that incorporating MRI data, in addition to clinical and biopsy findings, into nomograms can help for better preoperative risk assessment
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Shukla-Dave A, Hricak H, Akin O, et al. Preoperative nomograms incorporating magnetic resonance imaging and spectroscopy for prediction of insignificant prostate cancer. BJU Int 2011 [Epub ahead of print]. doi: 10.1111/j.1464-410X.2011.10612.x The study shows that incorporating MRI data, in addition to clinical and biopsy findings, into nomograms can help for better preoperative risk assessment.
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Shukla-Dave, A.1
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70350443250
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This is the first study showing radical prostatectomy findings after failure of active surveillance. Large cancers in this study were mainly anteriorly located
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Duffield AS, Lee TK, Miyamoto H, et al. Radical prostatectomy findings in patients in whom active surveillance of prostate cancer fails. J Urol 2009; 182:2274-2278. This is the first study showing radical prostatectomy findings after failure of active surveillance. Large cancers in this study were mainly anteriorly located.
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Ayres, B.E.1
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Correlation between MRI and whole-mounted pathologic radical prostatectomy sections is necessary to assess MRI findings. A detailed morphometric cancer evaluation according to the Stanford technique with mapping, identification of separate cancers and volume measurement provide quantitative data for imaging correlation
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Puech P, Potiron E, Lemaitre L, et al. Dynamic contrast-enhanced MRI evaluation of intraprostatic prostate cancer. Correlation with radical prostatectomy specimens. Urology 2009; 74:1094-1099. Correlation between MRI and whole-mounted pathologic radical prostatectomy sections is necessary to assess MRI findings. A detailed morphometric cancer evaluation according to the Stanford technique with mapping, identification of separate cancers and volume measurement provide quantitative data for imaging correlation.
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This study shows the interest of T2 and DCE for the description, localization and volume assessment of anterior prostate cancers in a prospective series of 27 cases with radical prostatectomy and rationally describes four types of anterior tumors
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Lemaitre L, Puech P, Poncelet E, et al. Dynamic contrast-enhanced MRI of anterior prostate cancer: morphometric assessment and correlation with radical prostatectomy findings. Eur Radiol 2009; 19:470-480. This study shows the interest of T2 and DCE for the description, localization and volume assessment of anterior prostate cancers in a prospective series of 27 cases with radical prostatectomy and rationally describes four types of anterior tumors.
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In this study, targeted biopsies to MRI suspicious areas detected 16% more Gleason grade 4 or 5 cancers and better quantified the burden of cancer than systematic biopsies, with a cancer core length involvement of 5.56 vs. 4.70mm (P=0.0018). These results demonstrate the role of prebiopsy MRI with targeted biopsies
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Haffner J, Lemaitre L, Puech P, et al. Role of magnetic resonance imaging before initial biopsy: comparison of magnetic resonance imaging-targeted and systematic biopsy for significant prostate cancer detection. BJU Int 2011; 108 (8 Pt 2):E171-E178. In this study, targeted biopsies to MRI suspicious areas detected 16% more Gleason grade 4 or 5 cancers and better quantified the burden of cancer than systematic biopsies, with a cancer core length involvement of 5.56 vs. 4.70mm (P=0.0018). These results demonstrate the role of prebiopsy MRI with targeted biopsies.
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