Expanding nature's chemical repertoire through metabolic engineering and biocatalysis

Current Opinion in Chemical Biology

Volumn 16, Issue 1-2, 2012, Pages 99-100

  Shen, Ben ^a   Thorson, Jon S ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NATURAL PRODUCT; NONRIBOSOMAL PEPTIDE SYNTHETASE; POLYKETIDE SYNTHASE; SAFRAMYCIN A;

BIOCATALYSIS; BIOINFORMATICS; DRUG INDUSTRY; EDITORIAL; HIGH THROUGHPUT SCREENING; METABOLIC ENGINEERING; METAGENOMICS; MICROORGANISM; NONHUMAN; PROTEIN STRUCTURE;

BIOCATALYSIS; BIOLOGICAL AGENTS; DATABASES, FACTUAL; METABOLIC ENGINEERING; PERIODICALS AS TOPIC;

EID: 84859632830     PISSN: 13675931     EISSN: 18790402     Source Type: Journal    
DOI: 10.1016/j.cbpa.2012.03.006     Document Type: Editorial

References (8)

1. Mishra B.B., Tiwari V.K. Natural products: an evolving role in future drug discovery. Eur J Med Chem 2011, 46:4769-4807.
2. Li J.W.H., Vederas J.C. Drug discovery and natural products: end of an era or an endless frontier?. Science 2009, 325:161-165.
3. Butler M.S. Natural products to drugs: natural product-derived compounds in clinical trials. Nat Prod Rep 2008, 25:475-516.
4. Schmitt E.K., Moore C.M., Krastel P., Petersen F. Natural products as catalysts for innovation: a pharmaceutical industry perspective. Curr Opin Chem Biol 2011, 15:497-504.
5. Newman D.J., Cragg G.M. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007, 70:461-477.
6. Bauer R.A., Wurst J.M., Tan D.S. Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective. Curr Opin Chem Biol 2010, 14:308-314.
7. Hert J., Irwin J.J., Laggner C., Keiser M.J., Shoichet B.K. Quantifying biogenic bias in screening libraries. Nat Chem Biol 2009, 5:479-483.
8. Dandapani S., Marcaurelle L.A. Accessing new chemical space for 'undruggable' targets. Nat Chem Biol 2010, 6:861-863.