The panicolytic-like effect of fluoxetine in the elevated T-maze is mediated by serotonin-induced activation of endogenous opioids in the dorsal periaqueductal grey

Journal of Psychopharmacology

Volumn 26, Issue 4, 2012, Pages 525-531

  Roncon, Camila M ^a   Biesdorf, Carla ^a   Santana, Rosangela G ^a   Zangrossi, Hélio ^b   Graeff, Frederico G ^b,c   Audi, Elisabeth A ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c Institute of Neurosciences and Behavior (INeC)   (Brazil)

Author keywords

animal model; antidepressant; endogenous opioids; panic; periaqueductal grey; Serotonin

Indexed keywords

ENDORPHIN; FLUOXETINE; NALOXONE; OPIATE; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DORSAL PERIAQUEDUCTAL GRAY MATTER; DRUG EFFECT; DRUG RESPONSE; ELEVATED T MAZE; ESCAPE BEHAVIOR; EXPERIMENTAL TEST; HYPOTHESIS; LOCOMOTION; MOLECULAR INTERACTION; NONHUMAN; PANIC; PANICOLYTIC LIKE EFFECT; PATHOPHYSIOLOGY; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM; TASK PERFORMANCE;

ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; FLUOXETINE; MALE; MAZE LEARNING; MOTOR ACTIVITY; NALOXONE; OPIOID PEPTIDES; PANIC DISORDER; PERIAQUEDUCTAL GRAY; RATS; RATS, WISTAR; SEROTONIN;

EID: 84859622792     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881111434619     Document Type: Article

References (26)

1. Diagnostic and Statistical Manual of Mental Disorders. 2000 ) Diagnostic and Statistical Manual of Mental Disorders, 4th ed., text revision. Washington, DC: American Psychiatric Press. Washington, DC: American Psychiatric Press ; 2000 :
2. Anseloni VC, Coimbra NC, Morato S, et al. A comparative study of the effects of morphine in the dorsal periaqueductal gray and nucleus accumbens of rats submitted to the elevated plus-maze test. Exp Brain Res. 1999 ; 129: 260-268
3. Broom DC, Jutkiewicz EM, Rice KC, et al. Behavioral effects of delta-opioid receptor agonists: Potential antidepressants?. Jpn J Pharmacol. 2002 ; 90: 1-6
4. Deakin JF, Graeff FG. 5-HT and mechanisms of defence. J Psychopharmacol. 1991 ; 5: 305-315
5. Del-Ben CM, Graeff FG. Panic disorder: Is the PAG involved?. Neural Plast. 2009 ;: 9
6. Graeff FG. On serotonin and experimental anxiety. Psychopharmacology. 2002 ; 163: 467-476
7. Graeff FG. Serotonin, the periaqueductal gray and panic disorder. Neurosci Biobehav Rev. 2004 ; 28: 239-259
8. Graeff FG, Del-Ben CM. Neurobiology of panic disorder: From animal models to brain neuroimaging. Neurosci Biobehav Rev. 2008 ; 32: 1326-1335
9. Graeff FG, Zangrossi H. The dual role of serotonin in defense and the mode of action of antidepressants on generalized anxiety and panic disorders. Cent Nerv Syst Agents Med Chem. 2010 ; 10: 207-217
10. Graeff FG, Viana MB, Tomaz C. The elevated T maze, a new experimental model of anxiety and memory: Effect of diazepam. Braz J Med Biol Res. 1993 ; 26: 67-70
11. Johnson PL, Lightman SL, Lowry CA. A functional subset of serotonergic neurons in the rat ventrolateral periaqueductal gray implicated in the inhibition of sympathoexcitation and panic. Ann N Y Acad Sci. 2004 ; 1018: 58-64
12. Johnson P, Lowry C, Truitt W, et al. Disruption of GABAergic tone in the dorsomedial hypothalamus attenuates responses in a subset of serotonergic neurons in the dorsal raphe nucleus following lactate-induced panic. J Psychopharmacol. 2008 ; 22: 642-652
13. Klein DF. False suffocation alarms, spontaneous panics, and related conditions. An integrative hypothesis. Arch Gen Psychiatry. 1993 ; 50: 306-317
14. Motta V, Brandão ML. Aversive and anti-aversive effects of morphine in the periaqueductal gray of rats submitted to the elevated plus-maze test. Pharmacol Biochem Behav. 1993 ; 44: 119-125
15. Paxinos G, Watson C The rat brain in stereotaxic coordinates. 1997 ) The rat brain in stereotaxic coordinates, 3rd ed.San Diego: Academic Press. San Diego: Academic Press ; 1997 :
16. Pinheiro SM, Zangrossi H, Del-Ben CM, et al. Elevated mazes as animal models of anxiety: Effects of serotonergic agents. An Acad Bras Cienc. 2007 ; 79: 71-85
17. Preter M, Klein DF. Panic, suffocation false alarms, separation anxiety and endogenous opioids. Prog Neuropsychopharmacol Biol Psychiatry. 2008 ; 32: 603-612
18. Preter M, Lee SH, Petkova E, et al. Controlled cross-over study in normal subjects of naloxone-preceding-lactate infusions; respiratory and subjective responses: Relationship to endogenous opioid system, suffocation false alarm theory and childhood parental loss. Psychol Med. 2011 ; 41: 385-393
19. Schenberg LC, Bittencourt AS, Sudré ECM, et al. Modeling panic attacks. Neurosci Biobehav Rev. 2001 ; 25: 647-659
20. Sinha SS, Goetz RR, Klein DF. Physiological and behavioral effects of naloxone and lactate in normal volunteers with relevance to the pathophysiology of panic disorder. Psychiatry Res. 2007 ; 149: 309-314
21. Teixeira RC, Zangrossi H, Graeff FG. Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety. Pharmacol Biochem Behav. 2000 ; 65: 571-576
22. Tiller JW, Bouwer C, Behnke K. Moclobemide and fluoxetine for panic disorder. International Panic Disorder Study Group. Eur. Arch Psychiatry Clin Neurosci. 1999 ;: S7 - S10
23. Wolozin BL, Pasternak GW. Classification of multiple morphine and enkephalin binding sites in the central nervous system. Proc Natl Acad Sci USA. 1981 ; 78: 6181-6185
24. Xuan YT, Shi YS, Zhou ZF, et al. Studies on the mesolimbic loop of antinociception-II. A serotonin-enkephalin interaction in the nucleus accumbens. Neuroscience. 1986 ; 19: 403-409
25. Zanoveli JM, Nogueira RL, Zangrossi H. Enhanced reactivity of 5-HT1A receptors in the rat dorsal periaqueductal grey matter after chronic treatment with fluoxetine and sertraline: Evidence from the elevated T-maze. Neuropharmacology. 2007 ; 52: 1188-1195
26. Zanoveli JM, Pobbe RLH, Bortoli VC, et al. Facilitation of 5-HT1A mediated neurotransmission in dorsal periaqueductal grey matter accounts for the panicolytic-like effect of chronic fluoxetine. Int J Neuropsychopharmacol. 2010 ; 13: 1079-1088