Pharmacokinetic profiles of epidural bupivacaine and ropivacaine following single-shot and continuous epidural use in young infants

Paediatric Anaesthesia

Volumn 22, Issue 5, 2012, Pages 430-437

  Calder, Alyson ^a   Bell, Graham T ^a   Andersson, Martin ^b   Thomson, Alison H ^b,c   Watson, David G ^b   Morton, Neil S ^a  

^a ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c WESTERN INFIRMARY   (United Kingdom)

Author keywords

analgesia, postoperative; anesthesia, epidural; bupivacaine; infant; neonate; pharmacokinetics; ropivacaine

Indexed keywords

BUPIVACAINE; OROSOMUCOID; ROPIVACAINE;

ABDOMINAL SURGERY; ADVERSE OUTCOME; ARTICLE; CLINICAL ARTICLE; DRUG BIOAVAILABILITY; FEMALE; HERNIOPLASTY; HUMAN; INFANT; MALE; PAIN; PEDIATRICS; PRIORITY JOURNAL; SINGLE DRUG DOSE;

AMIDES; ANESTHESIA, EPIDURAL; ANESTHESIA, GENERAL; ANESTHETICS, LOCAL; BUPIVACAINE; DATA INTERPRETATION, STATISTICAL; HERNIORRHAPHY; HUMANS; INFANT; INFANT, NEWBORN; OROSOMUCOID; PAIN, POSTOPERATIVE; POSTOPERATIVE CARE;

EID: 84859616599     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/j.1460-9592.2011.03771.x     Document Type: Article

References (27)

1. Eyres RL,. Local anaesthetic agents in infancy. Paediatr Anaesth 1995; 5: 213-218.
2. Larsson BA, Olsson GL, Lonnqvist PA,. Plasma concentrations of bupivacaine in young infants after continuous epidural infusion. Paediatr Anaesth 1994; 4: 159-162.
3. McCloskey JJ, Haun SE, Deshpande JK,. Bupivacaine toxicity secondary to continuous caudal epidural infusion in children. Anesth Analg 1992; 75: 287-290.
4. Hodgkinson K, Bear M, Thorn J, et al. Measuring pain in neonates: evaluating an instrument and developing a common language. Aust J Adv Nurs 1994; 12: 17-22.
5. Stumpe M, Morton NS, Watson DG,. Determination of free concentrations of ropivacaine and bupivacaine in plasma from neonates using small scale equilibrium dialysis followed by liquid chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl 2000; 748: 321-330.
6. Stumpe M, Miller C, Morton NS, et al. High performance liquid chromatography determination of α1-acid glycoprotein in small volumes of plasma from neonates. J Chromatogr 2006; 831: 81-84.
7. Beal S, Sheiner LB, Boeckmann A, et al. NONMEM User's Guides (1989-2006). Ellicott City, MD, USA: Icon Development Solutions, 2006.
8. Anderson BJ, Meakin GH,. Scaling for size: some implications for paediatric anaesthetic dosing. Paediatr Anaesth 2002; 12: 205-219.
9. Lindbom L, Pihlgren P, Jonsson EN,. PsN-Toolkit-a collection of computer intensive statistical methods for non-linear mixed effect modeling using NONMEM. Comput Methods Programs Biomed 2005; 79: 241-257.
10. Jonsson EN, Karlsson MO,. Xpose-an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM. Comput Methods Programs Biomed 1999; 58: 51-64.
11. R Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing, 2008. Available at:. Accessed 27 January, 2008.
12. Veering BT, Burm AG, Feyen HM, et al. Pharmacokinetics of bupivacaine during post-operative epidural infusion. Anesthesiology 2002; 96: 1062-1069.
13. Scott DA, Emmannuelsson B-M, Mooney PH, et al. Pharmacokinetics and efficacy of long-term epidural ropivacaine infusion for post-operative analgesia. Anesth Analg 1997; 85: 1322-1330.
14. Burm AGL, Stienstra R, Brouwer RP, et al. Epidural infusion of ropivacaine for post-operative analgesia after major orthopaedic surgery; pharmacokinetic evaluation. Anesthesiology 2000; 93: 395-403.
15. Meunier JF, Goujard E, Dubousset AM, et al. Pharmacokinetics of bupivacaine after continuous epidural infusion in infants with and without biliary atresia. Anesthesiology 2001; 95: 87-95.
16. Bosenberg AT, Thomas J, Cronje L, et al. Pharmacokinetics and efficacy of ropivacaine for continuous epidural infusion in neonates and infants. Pediatr Anesth 2005; 15: 739-749.
17. Knudsen K, Beckman Suurkula M, Blomberg S, et al. Central nervous and cardiovascular effect of IV infusion of ropivacaine, bupivacaine and placebo of volunteers. Br J Anaesth 1997; 78: 507-514.
18. Moore DC, Mather LE, Bridenbaugh LD, et al. Arterial and venous plasma levels of bupivacaine following peripheral nerve blocks. Anesth Analg 1976; 55: 763-768.
19. Hansen TG, Ilett KF, Lim SI, et al. Pharmacokinetics and clinical efficacy of long-term epidural ropivacaine infusion in children. Br J Anaesth 2000; 85: 347-353.
20. Rapp HJ, Molnar V, Austin S, et al. Ropivacaine in neonates and infants: a population pharmacokinetic evaluation following single caudal block. Pediatr Anesth 2004; 14: 724.
21. Lonnqvist PA, Westrin P, Larsson BA, et al. Ropivacaine pharmacokinetics after caudal block in 1-8 year old children. Br J Anaesth 2000; 85: 506-511.
22. Peutrell JM, Holder K, Gregory M,. Plasma bupivacaine concentrations associated with continuous extradural infusions in babies. Br J Anaesth 1997; 78: 160-162.
23. Chalkiadis GA, Anderson BJ, Tay M, et al. Pharmacokinetics of levobupivacaine after caudal epidural administration in infants less than 3 months of age. Br J Anaesth 2005; 95: 524-529.
24. de Wildt SN, Kearns GL, Leeder JS, et al. Cytochrome P450 3A: ontogeny and drug disposition. Clin Pharmacokinet 1999; 37: 485-505.
25. Booker PD, Taylor C, Saba G,. Perioperative changes in alpha-1-acid glycoprotein concentrations in infants undergoing major surgery. Br J Anaesth 1996; 76: 365-368.
26. 1-acid glycoprotein and the binding of lidocaine in pediatric patients. Clin Phamacol Ther 1989; 46: 219-225.
27. Capogna G, Celleno D, Fusco P, et al. Relative potencies of bupivacaine and ropivacaine for analgesia in labour. Br J Anaesth 1999; 82: 371-373.