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Volumn 34, Issue 4, 2012, Pages 811-823

Effects of CYP4F2 Polymorphism on Response to Warfarin During Induction Phase: A Prospective, Open-Label, Observational Cohort Study

Author keywords

3 hydroxy 3 methyl glutaryl coenzyme A reductase inhibitors; CYP4F2; Pharmacogenetics; Statin; Variability; Warfarin

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2C9; CYTOCHROME P450 4F2; UNCLASSIFIED DRUG; WARFARIN;

EID: 84859565615     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2012.02.009     Document Type: Article
Times cited : (22)

References (50)
  • 1
    • 45949103309 scopus 로고    scopus 로고
    • Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition)
    • Ansell J., Hirsh J., Hylek E., et al. Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest 2008, 133:160S-198S.
    • (2008) Chest , vol.133
    • Ansell, J.1    Hirsh, J.2    Hylek, E.3
  • 2
    • 1842778900 scopus 로고    scopus 로고
    • Physicians' attitudes and the use of oral anticoagulants: surveying the present and envisioning future
    • York M., Agarwal A., Ezekowitz M. Physicians' attitudes and the use of oral anticoagulants: surveying the present and envisioning future. J Thromb Thrombolysis 2003, 16:33-37.
    • (2003) J Thromb Thrombolysis , vol.16 , pp. 33-37
    • York, M.1    Agarwal, A.2    Ezekowitz, M.3
  • 3
    • 0037382537 scopus 로고    scopus 로고
    • American Heart Association/American College of Cardiology Foundation guide to warfarin therapy
    • Hirsh J., Fuster V., Ansell J., Halperin J.L. American Heart Association/American College of Cardiology Foundation guide to warfarin therapy. Circulation 2003, 107:1692-1711.
    • (2003) Circulation , vol.107 , pp. 1692-1711
    • Hirsh, J.1    Fuster, V.2    Ansell, J.3    Halperin, J.L.4
  • 4
    • 0027907652 scopus 로고
    • The spring meetings-are they dying?
    • Landefeld C.S. The spring meetings-are they dying?. N Engl J Med 1993, 328:1645-1647.
    • (1993) N Engl J Med , vol.328 , pp. 1645-1647
    • Landefeld, C.S.1
  • 5
    • 48249098212 scopus 로고    scopus 로고
    • Delivery of optimized anticoagulant therapy: consensus statement from the Anticoagulation Forum
    • Garcia D.A., Witt D.M., Hylek E., et al. Delivery of optimized anticoagulant therapy: consensus statement from the Anticoagulation Forum. Ann Pharmacother 2008, 42:979-988.
    • (2008) Ann Pharmacother , vol.42 , pp. 979-988
    • Garcia, D.A.1    Witt, D.M.2    Hylek, E.3
  • 6
    • 39449086981 scopus 로고    scopus 로고
    • CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: a prospective randomized controlled study
    • Caraco Y., Blotnick S., Muszkat M. CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: a prospective randomized controlled study. Clin Pharmacol Ther 2008, 83:460-470.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 460-470
    • Caraco, Y.1    Blotnick, S.2    Muszkat, M.3
  • 7
    • 0037305998 scopus 로고    scopus 로고
    • A Bayesian method based on clotting factor activity for the prediction of maintenance warfarin dosage regimens
    • Pitsiu M., Parker E.M., Aarons L., Rowland M. A Bayesian method based on clotting factor activity for the prediction of maintenance warfarin dosage regimens. Ther Drug Monit 2003, 25:36-40.
    • (2003) Ther Drug Monit , vol.25 , pp. 36-40
    • Pitsiu, M.1    Parker, E.M.2    Aarons, L.3    Rowland, M.4
  • 8
    • 0023238050 scopus 로고
    • Effect of using warfarin plasma concentrations in Bayesian forecasting of prothrombin-time response
    • Lee C., Coleman R.W., Mungall D.R. Effect of using warfarin plasma concentrations in Bayesian forecasting of prothrombin-time response. Clin Pharm 1987, 6:406-412.
    • (1987) Clin Pharm , vol.6 , pp. 406-412
    • Lee, C.1    Coleman, R.W.2    Mungall, D.R.3
  • 9
    • 70649095262 scopus 로고    scopus 로고
    • Warfarin-dosing algorithm based on a population pharmacokinetic/pharmacodynamic model combined with Bayesian forecasting
    • Sasaki T., Tabuchi H., Higuchi S., Ieiri I. Warfarin-dosing algorithm based on a population pharmacokinetic/pharmacodynamic model combined with Bayesian forecasting. Pharmacogenomics 2009, 10:1257-1266.
    • (2009) Pharmacogenomics , vol.10 , pp. 1257-1266
    • Sasaki, T.1    Tabuchi, H.2    Higuchi, S.3    Ieiri, I.4
  • 10
    • 33947227273 scopus 로고    scopus 로고
    • Association of warfarin dose with genes involved in its action and metabolism
    • Wadelius M., Chen L.Y., Eriksson N., et al. Association of warfarin dose with genes involved in its action and metabolism. Hum Genet 2007, 121:23-34.
    • (2007) Hum Genet , vol.121 , pp. 23-34
    • Wadelius, M.1    Chen, L.Y.2    Eriksson, N.3
  • 11
    • 0033608466 scopus 로고    scopus 로고
    • Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
    • Aithal G.P., Day C.P., Kesteven P.J., Daly A.K. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet 1999, 353:717-719.
    • (1999) Lancet , vol.353 , pp. 717-719
    • Aithal, G.P.1    Day, C.P.2    Kesteven, P.J.3    Daly, A.K.4
  • 12
    • 21144448879 scopus 로고    scopus 로고
    • Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose
    • Rieder M.J., Reiner A.P., Gage B.F., et al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N Engl J Med 2005, 352:2285-2293.
    • (2005) N Engl J Med , vol.352 , pp. 2285-2293
    • Rieder, M.J.1    Reiner, A.P.2    Gage, B.F.3
  • 13
    • 1542346414 scopus 로고    scopus 로고
    • Contribution of age, body size, and CYP2C9 genotype to anticoagulant response to warfarin
    • Kamali F., Khan T.I., King B.P., et al. Contribution of age, body size, and CYP2C9 genotype to anticoagulant response to warfarin. Clin Pharmacol Ther 2004, 75:204-212.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 204-212
    • Kamali, F.1    Khan, T.I.2    King, B.P.3
  • 14
    • 0036914221 scopus 로고    scopus 로고
    • Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance
    • Scordo M.G., Pengo V., Spina E., et al. Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance. Clin Pharmacol Ther 2002, 72:702-710.
    • (2002) Clin Pharmacol Ther , vol.72 , pp. 702-710
    • Scordo, M.G.1    Pengo, V.2    Spina, E.3
  • 15
    • 33645849823 scopus 로고    scopus 로고
    • Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements
    • Aquilante C.L., Langaee T.Y., Lopez L.M., et al. Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements. Clin Pharmacol Ther 2006, 79:291-302.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 291-302
    • Aquilante, C.L.1    Langaee, T.Y.2    Lopez, L.M.3
  • 16
    • 19144373497 scopus 로고    scopus 로고
    • CYP2C9 haplotype structure in European American warfarin patients and association with clinical outcomes
    • Veenstra D.L., Blough D.K., Higashi M.K., et al. CYP2C9 haplotype structure in European American warfarin patients and association with clinical outcomes. Clin Pharmacol Ther 2005, 77:353-364.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 353-364
    • Veenstra, D.L.1    Blough, D.K.2    Higashi, M.K.3
  • 17
    • 59649117935 scopus 로고    scopus 로고
    • The largest prospective warfarin-treated cohort supports genetic forecasting
    • Wadelius M., Chen L.Y., Lindh J.D., et al. The largest prospective warfarin-treated cohort supports genetic forecasting. Blood 2009, 113:784-792.
    • (2009) Blood , vol.113 , pp. 784-792
    • Wadelius, M.1    Chen, L.Y.2    Lindh, J.D.3
  • 18
    • 63449117825 scopus 로고    scopus 로고
    • A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose
    • Takeuchi F., McGinnis R., Bourgeois S., et al. A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. PLoS Genet 2009, 5:e1000433.
    • (2009) PLoS Genet , vol.5
    • Takeuchi, F.1    McGinnis, R.2    Bourgeois, S.3
  • 19
    • 34547138943 scopus 로고    scopus 로고
    • Evaluation of genetic factors for warfarin dose prediction
    • Caldwell M.D., Berg R.L., Zhang K.Q., et al. Evaluation of genetic factors for warfarin dose prediction. Clin Med Res 2007, 5:8-16.
    • (2007) Clin Med Res , vol.5 , pp. 8-16
    • Caldwell, M.D.1    Berg, R.L.2    Zhang, K.Q.3
  • 20
    • 0031015345 scopus 로고    scopus 로고
    • Human P450 metabolism of warfarin
    • Kaminsky L.S., Zhang Z.Y. Human P450 metabolism of warfarin. Pharmacol Ther 1997, 73:67-74.
    • (1997) Pharmacol Ther , vol.73 , pp. 67-74
    • Kaminsky, L.S.1    Zhang, Z.Y.2
  • 21
    • 11244332058 scopus 로고    scopus 로고
    • A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin
    • D'Andrea G., D'Ambrosio R.L., Di Perna P., et al. A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin. Blood 2005, 105:645-649.
    • (2005) Blood , vol.105 , pp. 645-649
    • D'Andrea, G.1    D'Ambrosio, R.L.2    Di Perna, P.3
  • 22
    • 23644437525 scopus 로고    scopus 로고
    • Common VKORC1 and GGCX polymorphisms associated with warfarin dose
    • Wadelius M., Chen L.Y., Downes K., et al. Common VKORC1 and GGCX polymorphisms associated with warfarin dose. Pharmacogenomics J 2005, 5:262-270.
    • (2005) Pharmacogenomics J , vol.5 , pp. 262-270
    • Wadelius, M.1    Chen, L.Y.2    Downes, K.3
  • 23
    • 27144539568 scopus 로고    scopus 로고
    • VKORC1 haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulation
    • Geisen C., Watzka M., Sittinger K., et al. VKORC1 haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulation. Thromb Haemost 2005, 94:773-779.
    • (2005) Thromb Haemost , vol.94 , pp. 773-779
    • Geisen, C.1    Watzka, M.2    Sittinger, K.3
  • 24
    • 33749258021 scopus 로고    scopus 로고
    • Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation
    • Li T., Lange L.A., Li X., et al. Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation. J Med Genet 2006, 43:740-744.
    • (2006) J Med Genet , vol.43 , pp. 740-744
    • Li, T.1    Lange, L.A.2    Li, X.3
  • 25
    • 28344440666 scopus 로고    scopus 로고
    • The vitamin K cycle
    • Stafford D.W. The vitamin K cycle. J Thromb Haemost 2005, 3:1873-1878.
    • (2005) J Thromb Haemost , vol.3 , pp. 1873-1878
    • Stafford, D.W.1
  • 26
    • 78650952998 scopus 로고    scopus 로고
    • Prevalent aetiologies of non-therapeutic warfarin anticoagulation in a network of pharmacist-managed anticoagulation clinics
    • Cryder B., Felczak M., Janociak J., et al. Prevalent aetiologies of non-therapeutic warfarin anticoagulation in a network of pharmacist-managed anticoagulation clinics. J Clin Pharm Ther 2011, 36:64-70.
    • (2011) J Clin Pharm Ther , vol.36 , pp. 64-70
    • Cryder, B.1    Felczak, M.2    Janociak, J.3
  • 27
    • 42149188553 scopus 로고    scopus 로고
    • CYP4F2 genetic variant alters required warfarin dose
    • Caldwell M.D., Awad T., Johnson J.A., et al. CYP4F2 genetic variant alters required warfarin dose. Blood 2008, 111:4106-4112.
    • (2008) Blood , vol.111 , pp. 4106-4112
    • Caldwell, M.D.1    Awad, T.2    Johnson, J.A.3
  • 28
    • 51649110496 scopus 로고    scopus 로고
    • A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose
    • Cooper G.M., Johnson J.A., Langaee T.Y., et al. A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood 2008, 112:1022-1027.
    • (2008) Blood , vol.112 , pp. 1022-1027
    • Cooper, G.M.1    Johnson, J.A.2    Langaee, T.Y.3
  • 29
    • 65549085682 scopus 로고    scopus 로고
    • CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population
    • Borgiani P., Ciccacci C., Forte V., et al. CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population. Pharmacogenomics 2009, 10:261-266.
    • (2009) Pharmacogenomics , vol.10 , pp. 261-266
    • Borgiani, P.1    Ciccacci, C.2    Forte, V.3
  • 30
    • 72849127064 scopus 로고    scopus 로고
    • Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients
    • Pautas E., Moreau C., Gouin-Thibault I., et al. Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients. Clin Pharmacol Ther 2010, 87:57-64.
    • (2010) Clin Pharmacol Ther , vol.87 , pp. 57-64
    • Pautas, E.1    Moreau, C.2    Gouin-Thibault, I.3
  • 31
    • 70349574149 scopus 로고    scopus 로고
    • Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy
    • Zhang J.E., Jorgensen A.L., Alfirevic A., et al. Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. Pharmacogenet Genomics 2009, 19:781-789.
    • (2009) Pharmacogenet Genomics , vol.19 , pp. 781-789
    • Zhang, J.E.1    Jorgensen, A.L.2    Alfirevic, A.3
  • 32
    • 73649117856 scopus 로고    scopus 로고
    • Genetic determinants of warfarin dosing in the Han-Chinese population
    • Lee M.T., Chen C.H., Chou C.H., et al. Genetic determinants of warfarin dosing in the Han-Chinese population. Pharmacogenomics 2009, 10:1905-1913.
    • (2009) Pharmacogenomics , vol.10 , pp. 1905-1913
    • Lee, M.T.1    Chen, C.H.2    Chou, C.H.3
  • 34
    • 77949873283 scopus 로고    scopus 로고
    • Genetic and clinical predictors of warfarin dose requirements in African Americans
    • Cavallari L.H., Langaee T.Y., Momary K.M., et al. Genetic and clinical predictors of warfarin dose requirements in African Americans. Clin Pharmacol Ther 2010, 87:459-464.
    • (2010) Clin Pharmacol Ther , vol.87 , pp. 459-464
    • Cavallari, L.H.1    Langaee, T.Y.2    Momary, K.M.3
  • 35
    • 66849132349 scopus 로고    scopus 로고
    • CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant
    • McDonald M.G., Rieder M.J., Nakano M., et al. CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant. Mol Pharmacol 2009, 75:1337-1346.
    • (2009) Mol Pharmacol , vol.75 , pp. 1337-1346
    • McDonald, M.G.1    Rieder, M.J.2    Nakano, M.3
  • 36
    • 34247174914 scopus 로고    scopus 로고
    • Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin
    • Hsu M.H., Savas U., Griffin K.J., Johnson E.F. Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin. J Biol Chem 2007, 282:5225-5236.
    • (2007) J Biol Chem , vol.282 , pp. 5225-5236
    • Hsu, M.H.1    Savas, U.2    Griffin, K.J.3    Johnson, E.F.4
  • 37
    • 33646152752 scopus 로고    scopus 로고
    • Comparison of bleeding in patients with nonvalvular atrial fibrillation treated with ximelagatran or warfarin: assessment of incidence, case-fatality rate, time course and sites of bleeding, and risk factors for bleeding
    • Douketis J.D., Arneklev K., Goldhaber S.Z., et al. Comparison of bleeding in patients with nonvalvular atrial fibrillation treated with ximelagatran or warfarin: assessment of incidence, case-fatality rate, time course and sites of bleeding, and risk factors for bleeding. Arch Intern Med 2006, 166:853-859.
    • (2006) Arch Intern Med , vol.166 , pp. 853-859
    • Douketis, J.D.1    Arneklev, K.2    Goldhaber, S.Z.3
  • 38
    • 0034668128 scopus 로고    scopus 로고
    • Management and dosing of warfarin therapy
    • Gage B.F., Fihn S.D., White R.H. Management and dosing of warfarin therapy. Am J Med 2000, 109:481-488.
    • (2000) Am J Med , vol.109 , pp. 481-488
    • Gage, B.F.1    Fihn, S.D.2    White, R.H.3
  • 39
    • 40449120615 scopus 로고    scopus 로고
    • Genetic determinants of response to warfarin during initial anticoagulation
    • Schwarz U.I., Ritchie M.D., Bradford Y., et al. Genetic determinants of response to warfarin during initial anticoagulation. N Engl J Med 2008, 358:999-1008.
    • (2008) N Engl J Med , vol.358 , pp. 999-1008
    • Schwarz, U.I.1    Ritchie, M.D.2    Bradford, Y.3
  • 40
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomwide studies
    • Storey J.D., Tibshirani R. Statistical significance for genomwide studies. Proc Natl Acad Sci USA 2003, 100:9440-9445.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2
  • 41
    • 0035829361 scopus 로고    scopus 로고
    • Controlling the false discovery rate in behavior genetics research
    • Benjamini Y., Drai D., Elmer G., et al. Controlling the false discovery rate in behavior genetics research. Behav Brain Res 2001, 125:279-284.
    • (2001) Behav Brain Res , vol.125 , pp. 279-284
    • Benjamini, Y.1    Drai, D.2    Elmer, G.3
  • 42
    • 33746613172 scopus 로고    scopus 로고
    • Main haplotypes and mutational analysis of vitamin K epoxide reductase (VKORC1) in a Swedish population: a retrospective analysis of case records
    • Osman A., Enstrom C., Arbring K., et al. Main haplotypes and mutational analysis of vitamin K epoxide reductase (VKORC1) in a Swedish population: a retrospective analysis of case records. J Thromb Haemost 2006, 4:1723-1729.
    • (2006) J Thromb Haemost , vol.4 , pp. 1723-1729
    • Osman, A.1    Enstrom, C.2    Arbring, K.3
  • 43
    • 1542346407 scopus 로고    scopus 로고
    • CYP2C9 genotypes and dose requirements during the induction phase of oral anticoagulant therapy
    • Peyvandi F., Spreafico M., Siboni S.M., et al. CYP2C9 genotypes and dose requirements during the induction phase of oral anticoagulant therapy. Clin Pharmacol Ther 2004, 75:198-203.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 198-203
    • Peyvandi, F.1    Spreafico, M.2    Siboni, S.M.3
  • 44
    • 70349571987 scopus 로고    scopus 로고
    • Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study
    • Jorgensen A.L., Al-Zubiedi S., Zhang J.E., et al. Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study. Pharmacogenet Genomics 2009, 19:800-812.
    • (2009) Pharmacogenet Genomics , vol.19 , pp. 800-812
    • Jorgensen, A.L.1    Al-Zubiedi, S.2    Zhang, J.E.3
  • 45
    • 40949129912 scopus 로고    scopus 로고
    • Structure and function of vitamin K epoxide reductase
    • Tie J.K., Stafford D.W. Structure and function of vitamin K epoxide reductase. Vitam Horm 2008, 78:103-130.
    • (2008) Vitam Horm , vol.78 , pp. 103-130
    • Tie, J.K.1    Stafford, D.W.2
  • 46
    • 0035100308 scopus 로고    scopus 로고
    • The association of vitamin K status with warfarin sensitivity at the onset of treatment
    • Cushman M., Booth S.L., Possidente C.J., et al. The association of vitamin K status with warfarin sensitivity at the onset of treatment. Br J Haematol 2001, 112:572-577.
    • (2001) Br J Haematol , vol.112 , pp. 572-577
    • Cushman, M.1    Booth, S.L.2    Possidente, C.J.3
  • 47
    • 20144366696 scopus 로고    scopus 로고
    • Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis
    • Chimowitz M.I., Lynn M.J., Howlett-Smith H., et al. Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis. N Engl J Med 2005, 352:1305-1316.
    • (2005) N Engl J Med , vol.352 , pp. 1305-1316
    • Chimowitz, M.I.1    Lynn, M.J.2    Howlett-Smith, H.3
  • 48
    • 74549205313 scopus 로고    scopus 로고
    • Fibrate/statin initiation in warfarin users and gastrointestinal bleeding risk
    • Schelleman H., Bilker W.B., Brensinger C.M., et al. Fibrate/statin initiation in warfarin users and gastrointestinal bleeding risk. Am J Med 2010, 123:151-157.
    • (2010) Am J Med , vol.123 , pp. 151-157
    • Schelleman, H.1    Bilker, W.B.2    Brensinger, C.M.3
  • 49
    • 33646817390 scopus 로고    scopus 로고
    • The impact of simvastatin on warfarin disposition and dose requirements
    • Sconce E.A., Khan T.I., Daly A.K., et al. The impact of simvastatin on warfarin disposition and dose requirements. J Thromb Haemost 2006, 4:1422-1424.
    • (2006) J Thromb Haemost , vol.4 , pp. 1422-1424
    • Sconce, E.A.1    Khan, T.I.2    Daly, A.K.3
  • 50
    • 51249111978 scopus 로고    scopus 로고
    • Expression of CYP4F2 in human liver and kidney: assessment using targeted peptide antibodies
    • Hirani V., Yarovoy A., Kozeska A., et al. Expression of CYP4F2 in human liver and kidney: assessment using targeted peptide antibodies. Arch Biochem Biophys 2008, 478:59-68.
    • (2008) Arch Biochem Biophys , vol.478 , pp. 59-68
    • Hirani, V.1    Yarovoy, A.2    Kozeska, A.3


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