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Volumn 72, Issue 1, 2012, Pages 66-71

Increased 2-hydroxylation of estrogen is associated with lower body fat and increased lean body mass in postmenopausal women

Author keywords

Body composition; Estrogen metabolism; Obesity

Indexed keywords

16ALPHA HYDROXYESTRONE; 2 HYDROXYESTRONE; ESTROGEN;

EID: 84859552299     PISSN: 03785122     EISSN: 18734111     Source Type: Journal    
DOI: 10.1016/j.maturitas.2012.02.002     Document Type: Article
Times cited : (16)

References (40)
  • 1
    • 0029133122 scopus 로고
    • Aromatase in bone cell: Association with osteoporosis in postmenopausal women
    • Nawata H, Tanaka S, Tanaka S, et al. Aromatase in bone cell: association with osteoporosis in postmenopausal women. J Steroid Biochem Mol Biol 1995;53(June (1-6)):165-74.
    • (1995) J Steroid Biochem Mol Biol , vol.53 , Issue.JUNE 1-6 , pp. 165-174
    • Nawata, H.1    Tanaka, S.2    Tanaka, S.3
  • 2
    • 0027167145 scopus 로고
    • P450 enzymes of estrogen metabolism
    • Martucci CP, Fishman J. P450 enzymes of estrogen metabolism. Pharmacol Ther 1993;57(February (2-3)):237-57.
    • (1993) Pharmacol Ther , vol.57 , Issue.FEBRUARY 2-3 , pp. 237-257
    • Martucci, C.P.1    Fishman, J.2
  • 4
    • 0031830896 scopus 로고    scopus 로고
    • Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes
    • Yamazaki H, Shaw PM, Guengerich FP, Shimada T. Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes. Chem Res Toxicol 1998;11(June (6)):659-65.
    • (1998) Chem Res Toxicol , vol.11 , Issue.JUNE 6 , pp. 659-665
    • Yamazaki, H.1    Shaw, P.M.2    Guengerich, F.P.3    Shimada, T.4
  • 5
    • 0034800442 scopus 로고    scopus 로고
    • Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol
    • Badawi AF, Cavalieri EL, Rogan EG. Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol. Metabolism 2001;50(September (9)):1001-3.
    • (2001) Metabolism , vol.50 , Issue.SEPTEMBER 9 , pp. 1001-1003
    • Badawi, A.F.1    Cavalieri, E.L.2    Rogan, E.G.3
  • 6
    • 0031746357 scopus 로고    scopus 로고
    • Differential effects of estrogen metabolites on bone and reproductive tissues of ovariectomized rats
    • Westerlind KC, Gibson KJ, Malone P, Evans GL, Turner RT. Differential effects of estrogen metabolites on bone and reproductive tissues of ovariectomized rats. J Bone Miner Res 1998;13(June (6)):1023-31.
    • (1998) J Bone Miner Res , vol.13 , Issue.JUNE 6 , pp. 1023-1031
    • Westerlind, K.C.1    Gibson, K.J.2    Malone, P.3    Evans, G.L.4    Turner, R.T.5
  • 7
    • 0033933345 scopus 로고    scopus 로고
    • The impact of endogenous estradiol metabolites on carcinogenesis
    • Lippert TH, Seeger H, Mueck AO. The impact of endogenous estradiol metabolites on carcinogenesis. Steroids 2000;65(July (7)):357-69.
    • (2000) Steroids , vol.65 , Issue.JULY 7 , pp. 357-369
    • Lippert, T.H.1    Seeger, H.2    Mueck, A.O.3
  • 8
    • 0017717477 scopus 로고
    • Direction of estradiol metabolism as a control of its hormonal action - Uterotrophic activity of estradiol metabolites
    • Martucci C, Fishman J. Direction of estradiol metabolism as a control of its hormonal action - uterotrophic activity of estradiol metabolites. Endocrinology 1977;101(December (6)):1709-15.
    • (1977) Endocrinology , vol.101 , Issue.DECEMBER 6 , pp. 1709-1715
    • Martucci, C.1    Fishman, J.2
  • 9
    • 0033714872 scopus 로고    scopus 로고
    • The oxidative metabolism of estradiol conditions postmenopausal bone density and bone loss
    • Leelawattana R, Ziambaras K, Roodman-Weiss J, et al. The oxidative metabolism of estradiol conditions postmenopausal bone density and bone loss. J Bone Miner Res 2000;15(December (12)):2513-20.
    • (2000) J Bone Miner Res , vol.15 , Issue.DECEMBER 12 , pp. 2513-2520
    • Leelawattana, R.1    Ziambaras, K.2    Roodman-Weiss, J.3
  • 10
    • 33845623833 scopus 로고    scopus 로고
    • Estrogen Hydroxylation in Osteoporosis
    • DOI 10.1016/S0065-2423(06)43007-9, PII S0065242306430079
    • Napoli N, Armamento-Villareal R. Estrogen hydroxylation in osteoporosis. Adv Clin Chem 2007;43:211-27. (Pubitemid 44960965)
    • (2007) Advances in Clinical Chemistry , vol.43 , pp. 211-227
    • Napoli, N.1    Armamento-Villareal, R.2
  • 12
    • 4043180615 scopus 로고    scopus 로고
    • Physical activity, body size, and estrogen metabolism in women
    • Matthews CE, Fowke JH, Dai Q, et al. Physical activity, body size, and estrogen metabolism in women. Cancer Causes Control 2004;15(June (5)):473-81.
    • (2004) Cancer Causes Control , vol.15 , Issue.JUNE 5 , pp. 473-481
    • Matthews, C.E.1    Fowke, J.H.2    Dai, Q.3
  • 13
    • 0030639624 scopus 로고    scopus 로고
    • Re: Ethnic differences in estrogen metabolism in healthy women
    • Coker AL, Crane MM, Sticca RP, Sepkovic DW. Re: ethnic differences in estrogen metabolism in healthy women. J Natl Cancer Inst 1997;89(January (1)):89-90.
    • (1997) J Natl Cancer Inst , vol.89 , Issue.JANUARY 1 , pp. 89-90
    • Coker, A.L.1    Crane, M.M.2    Sticca, R.P.3    Sepkovic, D.W.4
  • 14
    • 77954367293 scopus 로고    scopus 로고
    • Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment
    • Grover S, Gourie-Devi M, Baghel R, et al. Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment. Pharmacogenomics 2010;11(July (7)):927-41.
    • (2010) Pharmacogenomics , vol.11 , Issue.JULY 7 , pp. 927-941
    • Grover, S.1    Gourie-Devi, M.2    Baghel, R.3
  • 15
    • 0024391462 scopus 로고
    • Cigarette smoking alters hepatic estrogen metabolism in men: Implications for atherosclerosis
    • Michnovicz JJ, Hershcopf RJ, Haley NJ, Bradlow HL, Fishman J. Cigarette smoking alters hepatic estrogen metabolism in men: implications for atherosclerosis. Metabolism 1989;38(June (6)):537-41.
    • (1989) Metabolism , vol.38 , Issue.JUNE 6 , pp. 537-541
    • Michnovicz, J.J.1    Hershcopf, R.J.2    Haley, N.J.3    Bradlow, H.L.4    Fishman, J.5
  • 16
    • 0022883314 scopus 로고
    • Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking
    • Michnovicz JJ, Hershcopf RJ, Naganuma H, Bradlow HL, Fishman J. Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking. N Engl J Med 1986;315(November (21)):1305-9.
    • (1986) N Engl J Med , vol.315 , Issue.NOVEMBER 21 , pp. 1305-1309
    • Michnovicz, J.J.1    Hershcopf, R.J.2    Naganuma, H.3    Bradlow, H.L.4    Fishman, J.5
  • 17
    • 0025144270 scopus 로고
    • Dietary and pharmacological control of estradiol metabolism in humans
    • DOI 10.1111/j.1749-6632.1990.tb34303.x
    • Michnovicz JJ, Bradlow HL. Dietary and pharmacological control of estradiol metabolism in humans. Ann NY Acad Sci 1990;595:291-9. (Pubitemid 20282960)
    • (1990) Annals of the New York Academy of Sciences , vol.595 , pp. 291-299
    • Michnovicz, J.J.1    Bradlow, H.L.2
  • 18
    • 34248327292 scopus 로고    scopus 로고
    • Effects of dietary calcium compared with calcium supplements on estrogen metabolism and bone mineral density
    • Napoli N, Thompson J, Civitelli R, Armamento-Villareal RC. Effects of dietary calcium compared with calcium supplements on estrogen metabolism and bone mineral density. Am J Clin Nutr 2007;85(May (5)):1428-33.
    • (2007) Am J Clin Nutr , vol.85 , Issue.MAY 5 , pp. 1428-1433
    • Napoli, N.1    Thompson, J.2    Civitelli, R.3    Armamento-Villareal, R.C.4
  • 19
    • 0028967224 scopus 로고
    • Estrogen action on the bone mass of postmenopausal women is dependent on body mass and initial bone density
    • Armamento-Villareal R, Civitelli R. Estrogen action on the bone mass of postmenopausal women is dependent on body mass and initial bone density. J Clin Endocrinol Metab 1995;80(March (3)):776-82.
    • (1995) J Clin Endocrinol Metab , vol.80 , Issue.MARCH 3 , pp. 776-782
    • Armamento-Villareal, R.1    Civitelli, R.2
  • 20
    • 72449161164 scopus 로고    scopus 로고
    • Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults
    • Silver Spring
    • Shah K, Stufflebam A, Hilton TN, Sinacore DR, Klein S, Villareal DT. Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults. Obesity (Silver Spring) 2009;17(December (12)):2162-8.
    • (2009) Obesity , vol.17 , Issue.DECEMBER 12 , pp. 2162-2168
    • Shah, K.1    Stufflebam, A.2    Hilton, T.N.3    Sinacore, D.R.4    Klein, S.5    Villareal, D.T.6
  • 21
    • 0027988586 scopus 로고
    • Monoclonal antibody-based enzyme immunoassay for simultaneous quantitation of 2- and 16 alphahydroxyestrone in urine
    • Klug TL, Bradlow HL, Sepkovic DW. Monoclonal antibody-based enzyme immunoassay for simultaneous quantitation of 2- and 16 alphahydroxyestrone in urine. Steroids 1994;59(November (11)):648-55.
    • (1994) Steroids , vol.59 , Issue.NOVEMBER 11 , pp. 648-655
    • Klug, T.L.1    Bradlow, H.L.2    Sepkovic, D.W.3
  • 22
    • 12544249249 scopus 로고    scopus 로고
    • Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density
    • Napoli N, Villareal DT, Mumm S, et al. Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res 2005;20(February (2)):232-9.
    • (2005) J Bone Miner Res , vol.20 , Issue.FEBRUARY 2 , pp. 232-239
    • Napoli, N.1    Villareal, D.T.2    Mumm, S.3
  • 23
    • 4344674338 scopus 로고    scopus 로고
    • The oxidative metabolism of estrogen modulates response to ERT/HRT in postmenopausal women
    • Armamento-Villareal RC, Napoli N, Klug T, Civitelli R. The oxidative metabolism of estrogen modulates response to ERT/HRT in postmenopausal women. Bone 2004;35(September (3)):682-8.
    • (2004) Bone , vol.35 , Issue.SEPTEMBER 3 , pp. 682-688
    • Armamento-Villareal, R.C.1    Napoli, N.2    Klug, T.3    Civitelli, R.4
  • 24
    • 0035192862 scopus 로고    scopus 로고
    • 2-Hydroxyestradiol attenuates the development of obesity, the metabolic syndrome, and vascular and renal dysfunction in obese ZSF1 rats
    • Tofovic SP, Dubey RK, Jackson EK. 2-Hydroxyestradiol attenuates the development of obesity, the metabolic syndrome, and vascular and renal dysfunction in obese ZSF1 rats. J Pharmacol Exp Ther 2001;299(December (3)): 973-7.
    • (2001) J Pharmacol Exp Ther , vol.299 , Issue.DECEMBER 3 , pp. 973-977
    • Tofovic, S.P.1    Dubey, R.K.2    Jackson, E.K.3
  • 25
    • 33846561588 scopus 로고    scopus 로고
    • 2-Methoxyestradiol and 2- ethoxyestradiol retard the progression of renal disease in aged, obese, diabetic ZSF1 rats
    • Zhang X, Jia Y, Jackson EK, Tofovic SP. 2-Methoxyestradiol and 2- ethoxyestradiol retard the progression of renal disease in aged, obese, diabetic ZSF1 rats. J Cardiovasc Pharmacol 2007;49(January (1)):56-63.
    • (2007) J Cardiovasc Pharmacol , vol.49 , Issue.JANUARY 1 , pp. 56-63
    • Zhang, X.1    Jia, Y.2    Jackson, E.K.3    Tofovic, S.P.4
  • 26
    • 44449161505 scopus 로고    scopus 로고
    • Estradiol and the estradiol metabolite, 2-hydroxyestradiol, activate AMP-activated protein kinase in C2C12 myotubes
    • Silver Spring
    • D'Eon TM, Rogers NH, Stancheva ZS, Greenberg AS. Estradiol and the estradiol metabolite, 2-hydroxyestradiol, activate AMP-activated protein kinase in C2C12 myotubes. Obesity (Silver Spring) 2008;16(June (6)):1284-8.
    • (2008) Obesity , vol.16 , Issue.JUNE 6 , pp. 1284-1288
    • D'Eon, T.M.1    Rogers, N.H.2    Stancheva, Z.S.3    Greenberg, A.S.4
  • 27
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    • Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005;1(January (1)):15-25.
    • (2005) Cell Metab , vol.1 , Issue.JANUARY 1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 28
    • 56449117024 scopus 로고    scopus 로고
    • AMPK: A metabolic gauge regulating whole-body energy homeostasis
    • Lage R, Dieguez C, Vidal-Puig A, Lopez M. AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol Med 2008;14(December (12)):539-49.
    • (2008) Trends Mol Med , vol.14 , Issue.DECEMBER 12 , pp. 539-549
    • Lage, R.1    Dieguez, C.2    Vidal-Puig, A.3    Lopez, M.4
  • 29
    • 0037031840 scopus 로고    scopus 로고
    • Coordinate regulation of malonyl- CoA decarboxylase, sn-glycerol-3- phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise
    • Park H, Kaushik VK, Constant S, et al. Coordinate regulation of malonyl- CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J Biol Chem 2002;277(September (36)):32571-7.
    • (2002) J Biol Chem , vol.277 , Issue.SEPTEMBER 36 , pp. 32571-32577
    • Park, H.1    Kaushik, V.K.2    Constant, S.3
  • 30
  • 31
    • 0034234293 scopus 로고    scopus 로고
    • Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: Association of polymorphisms with functional differences in estrogen hydroxylation activity
    • Hanna IH, Dawling S, Roodi N, Guengerich FP, Parl FF. Cytochrome P450 1B1(CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity. Cancer Res 2000;60(July (13)):3440-4.
    • (2000) Cancer Res , vol.60 , Issue.JULY 13 , pp. 3440-3444
    • Hanna, I.H.1    Dawling, S.2    Roodi, N.3    Guengerich, F.P.4    Parl, F.F.5
  • 32
    • 0032867995 scopus 로고    scopus 로고
    • Catalytic properties of polymorphic human cytochrome P450 1B1 variants
    • Shimada T, Watanabe J, Kawajiri K, et al. Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Carcinogenesis 1999;20(August (8)):1607-13.
    • (1999) Carcinogenesis , vol.20 , Issue.AUGUST 8 , pp. 1607-1613
    • Shimada, T.1    Watanabe, J.2    Kawajiri, K.3
  • 33
    • 33644825834 scopus 로고    scopus 로고
    • Estrogen metabolites and systolic blood pressure in a population-based sample of postmenopausal women
    • Masi CM, Hawkley LC, Berry JD, Cacioppo JT. Estrogen metabolites and systolic blood pressure in a population-based sample of postmenopausal women. J Clin Endocrinol Metab 2006;91(March (3)):1015-20.
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.MARCH 3 , pp. 1015-1020
    • Masi, C.M.1    Hawkley, L.C.2    Berry, J.D.3    Cacioppo, J.T.4
  • 34
    • 0028093334 scopus 로고
    • Consumption of calcium in the U.S.: Food sources and intake levels
    • Fleming KH, Heimbach JT. Consumption of calcium in the U.S.: food sources and intake levels. J Nutr 1994;124(August (8 Suppl.)):1426S-30S.
    • (1994) J Nutr , vol.124 , Issue.AUGUST 8 SUPPL.
    • Fleming, K.H.1    Heimbach, J.T.2
  • 35
    • 48649087385 scopus 로고    scopus 로고
    • Recent developments in calcium-related obesity research
    • Major GC, Chaput JP, Ledoux M, et al. Recent developments in calcium-related obesity research. Obes Rev 2008;9(September (5)):428-45.
    • (2008) Obes Rev , vol.9 , Issue.SEPTEMBER 5 , pp. 428-445
    • Major, G.C.1    Chaput, J.P.2    Ledoux, M.3
  • 36
    • 0036548811 scopus 로고    scopus 로고
    • Regulation of adiposity and obesity risk by dietary calcium: Mechanisms and implications
    • Zemel MB. Regulation of adiposity and obesity risk by dietary calcium: mechanisms and implications. J Am Coll Nutr 2002;21(April (2)):146S-51S.
    • (2002) J Am Coll Nutr , vol.21 , Issue.APRIL 2
    • Zemel, M.B.1
  • 37
    • 0027312187 scopus 로고
    • On the relationships between mineral metabolism, obesity and fat distribution
    • Lind L, Lithell H, Hvarfner A, Pollare T, Ljunghall S. On the relationships between mineral metabolism, obesity and fat distribution. Eur J Clin Invest 1993;23(May (5)):307-10.
    • (1993) Eur J Clin Invest , vol.23 , Issue.MAY 5 , pp. 307-310
    • Lind, L.1    Lithell, H.2    Hvarfner, A.3    Pollare, T.4    Ljunghall, S.5
  • 38
    • 0021227615 scopus 로고
    • The influence of dietary protein and carbohydrate on the principal oxidative biotransformations of estradiol in normal subjects
    • Anderson KE, Kappas A, Conney AH, Bradlow HL, Fishman J. The influence of dietary protein and carbohydrate on the principal oxidative biotransformations of estradiol in normal subjects. J Clin Endocrinol Metab 1984;59(July (1)):103-7.
    • (1984) J Clin Endocrinol Metab , vol.59 , Issue.JULY 1 , pp. 103-107
    • Anderson, K.E.1    Kappas, A.2    Conney, A.H.3    Bradlow, H.L.4    Fishman, J.5
  • 39
    • 70350096276 scopus 로고    scopus 로고
    • Soy intake is associated with increased 2-hydroxylation and decreased 16alpha-hydroxylation of estrogens in Asian-American women
    • Fuhrman BJ, Pfeiffer R, Xu X, et al. Soy intake is associated with increased 2-hydroxylation and decreased 16alpha-hydroxylation of estrogens in Asian-American women. Cancer Epidemiol Biomarkers Prev 2009;18(October (10)):2751-60.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , Issue.OCTOBER 10 , pp. 2751-2760
    • Fuhrman, B.J.1    Pfeiffer, R.2    Xu, X.3
  • 40
    • 34347349138 scopus 로고    scopus 로고
    • Effect of energy deficiency on estrogen metabolism in premenopausal women
    • Westerlind KC, Williams NI. Effect of energy deficiency on estrogen metabolism in premenopausal women. Med Sci Sports Exerc 2007;39(July (7)):1090-7.
    • (2007) Med Sci Sports Exerc , vol.39 , Issue.JULY 7 , pp. 1090-1097
    • Westerlind, K.C.1    Williams, N.I.2


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