Study of drug-drug interactions in prescriptions of general practitioners and specialists in Iran 2007-2009

Iranian Journal of Pharmaceutical Research

Volumn 10, Issue 4, 2011, Pages 921-931

  Ahmadizar, Fariba ^a   Soleymani, Fatemeh ^a   Abdollahi, Mohammad ^b  

^a MINISTRY OF HEALTH AND MEDICAL EDUCATION   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Clinical significant; Drug drug interactions; Patient; Polypharmacy

Indexed keywords

ALLOPURINOL; AMIODARONE; AMITRIPTYLINE; ANTIARRHYTHMIC AGENT; ANTIHYPERTENSIVE AGENT; ATORVASTATIN; AZITHROMYCIN; CAPTOPRIL; CARDIOVASCULAR AGENT; CENTRAL NERVOUS SYSTEM AGENTS; CHLORPROMAZINE; CLONIDINE; DIGITALIS; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; DOXYCYCLINE; FUROSEMIDE; GEMFIBROZIL; HALOPERIDOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MACROLIDE; MEVINOLIN; PENICILLIN G; PROPRANOLOL; TETRACYCLINE; TRIAMTERENE; UNINDEXED DRUG; VERAPAMIL; WARFARIN;

ARTICLE; CARDIOLOGIST; COMPUTER ANALYSIS; COMPUTER PROGRAM; DERMATOLOGIST; DRUG DRUG INTERACTION; DRUG INTERACTION; GENERAL PRACTITIONER; GENERAL SURGEON; HUMAN; INFECTION; INTERNIST; IRAN; MEDICAL SPECIALIST; MEDICATION ERROR; NEUROLOGIST; NEUROSURGEON; OPHTHALMOLOGIST; OPHTHALMOLOGY; ORTHOPEDIC SPECIALIST; OTORHINOLARYNGOLOGY; PEDIATRICIAN; POLYPHARMACY; PRESCRIPTION; PSYCHIATRIST; SURGEON; UROLOGIST;

EID: 84859521724     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Jankel CA and Speedie SM. Detecting drug interactions: a review of the literature. DICP. (1990) 24: 982-89.
2. Jankel CA and Fitterman LK. Epidemiology of drug-drug interactions as a cause of hospital admissions. Drug Saf. (1993) 9:51-59.
3. Hajebi G, Mortazavi SA. An Investigation of drug interactions in hospital pharmacy prescriptions. Iranian J. Pharm. Res. (2002) 1: 15-19.
4. Tatro DS, ed. Drug Interaction Facts. St. Louis, MO: Facts and Comparisons. (2001).
5. Lazarou J, Pomeranz BH and Corey PN. incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA. (1998) 279:1200-5.
6. Elinarson TR. Drug-related hospital admissions. Ann Pharmacother. (1993) 27:832-840.
7. Abbasi Nazari M, Khanzadeh Moqhadam N. Evaluation of pharmacokinetic drug interactions in prescriptions of intensive care unit (ICU) in a teaching hospital. Iranian J. Pharm. Res. (2006) 5: 215-218.
8. David N. Juurlink Mamdani M, Kopp A and Laupacis A. Drug-Drug interactions Among Elderly Patients hospitalized for drug toxicity, JAMA. (2003) 289:1652-8.
9. Jha AK, Kuperman GJ, Rittenberg E, Teich JM and Bates DW. Identifying hospital admissions due to adverse drug events using a computer-based monitor. Pharmacoepidemiol Drug saf. (2001) 10:113-119.
10. Shapiro LE and Shear NH. Drug-drug interactions: how scared should we be? CMAJ. (1999) 161:1266-1267.
11. Peterson JE and Bates DW. Preventable medication errors: identifying and eliminating serious drug interactions. J AM Pharm Assoc (Wash). (2001) 41:159-160.
12. Hansten PD, Horn JR and Hazlet TK. ORCA: OpeRational Classific Action of drug interactions. J AM Pharm Assoc (Wash). (2001) 41:161-165.
13. Leape LL, Brennan TA and Laird N. The nature of adverse events in hospitalized patients: results of the Harvard Medical Practice Study. N Engl Med. (1991) 324:377-384.
14. Bates DW, Cullen DJ and Laird N. Incidence of adverse drug events and potential adverse drug events: implications for prevention: ADE prevention Study Group. JAMA. (1995) 274:29-34.
15. Halkin H, Katzir I, Kurman I, Jan J and Malkin BB. Preventing drug interactions by online prescription screening in community pharmacies and medical practices. Clin Pharmacol Ther. (2001) 69: 260-265.
16. Catherine C Peng, Peter A Glassman, Iny R Marks, Curtis Fowler, Brenda Castiglione and Chester B Good. Retrospective Drug Utilization Review: Incidence of Clinically Relevant Potential Drug-Drug Interactions in a Large Ambulatory Population. Journal of managed care pharmacy (JMCP). (2003) 9:513-522.
17. Shaoul R, Shahory R, Tamir A and Jaffe M. Comparison between pediatricians and family practitioners in the use of the prokinetic cisapride for gastroesophageal reflux disease in children. Pediatrics. (2002) 109:1118-1123.
18. Langdorf MI, Fox JC, Marwah RS, Montague BJ and Hart MM. Physician versus computer knowledge of potential drug interactions in the emergency department. Acad Emerg Med. (2000) 7: 1321-1329.
19. Weideman RA, Bernstein IH and Mckinney WP. Pharmacist recognition of potential drug interactions. Amj Health Syst Pharm. (1999) 1524-1529.
20. Cavuto NJ, Woosley RL and Sale M. Pharmacies and prevention of potentially fatal drug interactions. JAMA. (1996) 275:1086-1087.
21. Glassman PA, Simon B, Belperio P and Lanto A. Improving recognition of drug interactions: benefits and barriers to using automated drug alerts. Med Care. (2002) 40:1161-1171.
22. Hazlet TK, Lee TA, Hansten PD and Horn JR. Performance of community pharmacy drug interaction software. J AM Pharm Assoc (Wash). (2001) 41: 200-204.
23. Del Fiol G, Rocha BH, Kuperman GJ, Bates DW and Nohama P. Comparison of two knowledge bases on the detection of drug-drug interactions. Proc AMIA Symp. (2000) 171-175.
24. Tatro DS, ed. Drug Interaction Facts. St. Louis, MO: Facts and Comparisons. (2005).
25. Straubhaar B, Krähenbühl S and Schlienger RG. The prevalence of potential drug-drug interactions in patients with heart failure at hospital discharge. Drug Saf. (2006) 29:79-90.
26. Egger T, Dormann H, Ahne G, Runge U, Azaz-Livshits T and Neubert A. Identification of adverse drug reactions in geriatric inpatients using a computerised drug database. Drugs Aging. (2003) 20:769-76.
27. Malone DC, Hutchins DS, Haupert H, Hansten P, Duncan B and Van Berger RC. Assessment of potential drug-drug interactions with a prescription claims database. Am J Health-Syst Pharm. (2005) 62: 1983-91.
28. Dambro MR and Kallgren MA. Drug interactions in a clinic using COSTAR. Comput. Biol. Med. (1988) 18:31-8.
29. Kurfees JF and Dotson RL. Drug interactions in the elderly. J. Fam. Pract. (1987) 25:477-88.
30. Gosney M and Tallis R. Prescription of contraindicated and interacting drugs in elderly patients admitted to hospital. Lancet. (1984) 8:564-7.
31. Linnarsson R. Drug interactions in primary health care. A retrospective database study and its implications for the design of a computerized decision support system. Scand J. Prim Health Care. (1993) 11:181-6.
32. Bergk V, Gasse C, Rothenbacher D, Loew M, Brenner H and Haefeli WE. Drug interactions in primary care: impact of a new algorithm on risk determination. Clin. Pharmacol. Ther. (2004) 76:85-96.
33. Ansari KU, Singh S and Pandey RC. Evaluation of prescribing pattern of doctors for rational drug therapy. Indian J Pharmacol. (1998) 30:43-46.
34. Jahangiri Bijan; Delfan Aziz and Fahimi Fanak. The Study of 5100 Prescriptions in Tehran. Nabz. (1375) 5: 56-62.
35. Mortaza-Semnani K, Saeidi M and Qaripour M. The study of drug interactions of cardiovascular drugs on insurance prescriptions of shahre sari>s drug stores in the years 1378-1379. Research Medical Article of the University of Medicine, Mazandaran (1380) 32: 37-45.
36. Karami Narges. The Study of Outpatient Prescriptions for the Effects of Drug Interactions. Doctorate Thesis of Pharmacology, Tehran: Pharmacology Department of the University of Medical Sciences. Tehran. (1995).
37. Bjerrum L, Andersen M and Petersen G. Exposure to potential drug interactions in primary health care. Scand. J. Prim. Health Care. (2003) 21:153-8.
38. Jankel CA, Speedie S. Detecting drug interactions: a review of the literature. Ann. Pharmacother. (1990) 24:982-9.
39. Björkman IK, Fastbom J and Schmidt IK. The Pharmaceutical Care of the Elderly in Europe Research (PEER) Group. Drug-drug interactions in the elderly. Ann. Pharmacother. (2002) 36:1675-81.
40. Bergendal L, Friberg A, Schaffrath A. Potential drug-drug interactions in 5,125 mostly elderly out-patients in Gothenburg, Sweden. Pharm World Sci. (1995) 17:152-7.
41. Costa AJ. Potential drug interactions in an ambulatory geriatric population. Fam. Pract. (1991) 8:234-6.
42. Rosholm JU, Bjerrum L and Hallas J. Polypharmacy and the risk of drug-drug interactions among Danish elderly. Dan. Med. Bull. (1998) 45:210-3.
43. Guédon-Moreau L, Ducrocq D and Duc MF. Absolute contraindications in relation to potential drug interactions in outpatient prescriptions: analysis of the first five million prescriptions in 1999. Eur. J. Clin. Pharmacol. (2003) 59:689-95.
44. Köhler GI, Bode-Böger SM and Busse R. Drug-drug interactions in medical patients: effects of in-hospital treatment and relation to multiple drug use. Int J Clin Pharmacol Ther. (2000) 38:504-13.
45. Grönroos PE, Irjala KM and Huupponen RK. A medication database--a tool for detecting drug interactions in hospital. Eur J Clin Pharmacol. (1997) 53:13-7.
46. Glintborg B, Andersen SE, Dalhoff K. Drug-drug interactions among recently hospitalized patients-frequent but mostly clinically insignificant. Eur J Clin Pharmacol. (2005) 61(9):675-681.
47. Cruciol-Souza JM, Thomson JC. Prevalence of potential drug-drug interactions and its associated factors in a Brazilian teaching hospital. J Pharm Pharm Sci.(2006) 9(3):427-433.
48. Bjorkman IK, Fastbom J, Schmidt IK and Bernsten CB. Drug-drug interactions in the elderly. Ann Pharmacotherapy. (2002) 36(11):1675-81.
49. Costa AJ. Potential drug interactions in an ambulatory geriatric population. Fam. Pract. (1991) 8:234-6.
50. Bergendal L, Friberg A and Schaffrath A. Potential drug--drug interactions in 5,125 mostly elderly out-patients in Gothenburg, Sweden. Pharm. World Sci. (1995) 17:152-7.
51. Bjerrum L, Andersen M, Petersen G and Kragstrup J. Exposure to potential drug interactions in primary health care. Scand. J. Prim. Health Care. (2003) 21:153-8.
52. Chen YF, Avery AJ, Neil KE, Johnson C, Dewey ME and Stockley IH. Incidence and possible causes of prescribing potentially hazardous/contraindicated drug combinations in general practice. Drug Saf. (2005) 28:67-80.
53. Teich JM, Merchia PR, Schmiz JL, Kuperman GJ, Spurr CD and Bates DW. Effects of computerized physician order entry on prescribing practices. Arch Inter Med. (2000) 160:2741-47.
54. Falconnier AD, Haefeli WE, Schoenenberger RA, Surber C and Martin-Facklam M. Drug dosage in patients with renal failure optimized by immediate concurrent feedback. J. Gen Intern Med. (2001) 16:369-75.
55. Barker KN, Flynn EA, Pepper GA, Bates DW and Mikeal RL. Medication errors observed in 36 health care facilities. Arch. Intern. Med. (2002) 162: 1897-1903.
56. Raschke RA, Gollihare B and Wunderlich TA. A computer alert system to prevent injury from adverse drug events: development and evaluation in a community teaching hospital. JAMA. (1998) 280:1317-20.
57. Schiff GD, Aggarwal HC, Kumar S and McNutt RA. Prescribing potassium despite hyperkalemia: medication errors uncovered by linking laboratory and pharmacy information systems. Am. J. Med. (2000) 109:494-97.
58. Galanter WL, Didomenico R and Polikaitis A. Analysis of medication safety alerts for inpatient digoxin use with computerized physician order entry. J. Gen Intern. Med. (2002) 17:193.
59. Monane M, Matthias DM, Nagle BA and Kelly MA. Improving prescribing patterns for the elderly through an online drug utilization review intervention: a system linking the physician, pharmacist and computer. JAMA. (1998) 280:1249-52.
60. Lesar TS, Briceland L and Stein DS. Factors related to errors in medication prescribing. JAMA. (1997) 277:312-17.
61. Bates DW, Leape LL and Cullen DJ. Effect of computerized physician order entry and a team intervention on prevention of serious medication errors. JAMA. (1998) 280:1311-16.
62. Kuperman GJ, Bates DW, Teich JM, Schneider JR and Cheiman D. A new knowledge structure for drug-drug interactions. Proc Annu Symp. Comput. Appl. Med. Care. (1994) 836-40.
63. Leape LL, Cullen DJ and Clapp MD. Pharmacist participation on physician rounds and adverse drug events in the intensive care unit. JAMA. (1999) 282:267-70.
64. Peterson JF, Kuperman GJ, Shek C and Bates DW. Physician responses to lifethreatening drug-drug interaction alerts. J. Gen Intern. Med. (2001)16: 212.
65. J Peral Aguirregoitia, U Lertxundi Etxebarria, M. J Martínez Bengoechea, O Mora Atorrasagasti, E Franco Lamela and I Gabilondo Zelaia, Prospective assessment of drug interactions in hospitalized patients using a computer programme, Farm. Hosp. (2007) 31:93-100.
66. Dambro MR and Kallgren MA. Drug interaction in a clinic using Costar. Comput Biol. Med. (1988) 18: 31-38.
67. Sihvo S, Klaukka T and Martikainen J. Frequency of daily over-the-counter drug use and potential clinically significant over-the-counter-prescription drug interactions in the Finnish adult population. Eur J. Clin. Pharmacol. (2000) 56:496-799.