Cross-talk between integrin α6β4 and Insulin-like Growth Factor-1 Receptor (IGF1R) through direct α6β4 binding to IGF1 and subsequent α6β4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions

Journal of Biological Chemistry

Volumn 287, Issue 15, 2012, Pages 12491-12500

  Fujita, Masaaki ^a   Ieguchi, Katsuaki ^a   Davari, Parastoo ^a   Yamaji, Satoshi ^a   Taniguchi, Yukimasa ^b   Sekiguchi, Kiyotoshi ^b   Takada, Yoko K ^a   Takada, Yoshikazu ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER PROGRESSION; CELL SURVIVAL; CELL-MATRIX ADHESION; COLONY FORMATION; CURRENT MODELS; EXTRACELLULAR MATRIX PROTEIN; IN-VIVO; INSULIN-LIKE GROWTH FACTOR-1; INSULIN-LIKE GROWTH FACTOR-1 RECEPTORS; INTEGRINS; INTRACELLULAR SIGNALING; SOFT AGAR; TERNARY COMPLEX; THERAPEUTIC TARGETS;

ADHESION; ANCHORAGES (FOUNDATIONS); CROSSTALK; DISEASES; INSULIN; PEPTIDES;

SIGNALING;

AGAR; ALPHA6BETA4 INTEGRIN; BETA1 INTEGRIN; BETA3 INTEGRIN; MUTANT PROTEIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; VITRONECTIN RECEPTOR;

AMINO ACID SEQUENCE; ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; CANCER GROWTH; CELL ADHESION; CELL SURVIVAL; COLONY FORMATION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG TARGETING; EXTRACELLULAR MATRIX; INTRACELLULAR SIGNALING; LIGAND BINDING; LIGAND OCCUPANCY; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL ADHESION; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; GENE EXPRESSION; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTEGRIN ALPHA6BETA4; MICE; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; RECEPTOR CROSS-TALK; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION;

EID: 84859515413     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.304170     Document Type: Article

References (35)

1. Clemmons, D. R. (2007) Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis, and cancer. Nat. Rev. Drug Discov. 6, 821-833
2. Clemmons, D. R., and Maile, L. A. (2005) Interaction between insulin-like growth factor-1 receptor- and αvβ3 integrin-linked signaling pathways: cellular responses to changes in multiple signaling inputs. Mol. Endocrinol. 19, 1-11 (Pubitemid 40065954)
3. Jones, J. I., Doerr, M. E., and Clemmons, D. R. (1995) Cell migration: interactions among integrins, IGFs and IGFBPs. Prog. Growth Factor Res. 6, 319-327
4. Zheng, B., and Clemmons, D. R. (1998) Blocking ligand occupancy of the αvβ3 integrin inhibits insulin-like growth factor-1 signaling in vascular smooth muscle cells. Proc. Natl. Acad. Sci. U.S.A. 95, 11217-11222 (Pubitemid 28450108)
5. Saegusa, J., Yamaji, S., Ieguchi, K., Wu, C. Y., Lam, K. S., Liu, F. T., Takada, Y. K., and Takada, Y. (2009) The direct binding of insulin-like growth factor-1 (IGF-1) to integrin αvβ3 is involved in IGF-1 signaling. J. Biol. Chem. 284, 24106-24114
6. Nishiuchi, R., Takagi, J., Hayashi, M., Ido, H., Yagi, Y., Sanzen, N., Tsuji, T., Yamada, M., and Sekiguchi, K. (2006) Ligand-binding specificities of laminin-binding integrins: a comprehensive survey of laminin-integrin interactions using recombinant α3β1, α6β1, α7β1, and α6β4 integrins. Matrix Biol. 25, 189-197
7. Takagi, J., Kamata, T., Meredith, J., Puzon-McLaughlin, W., and Takada, Y. (1997) Changing ligand specificities of αvβ1 and αvβ3 integrins by swapping a short diverse sequence of the β subunit. J. Biol. Chem. 272, 19794-19800 (Pubitemid 27340072)
8. Borowsky, A. D., Namba, R., Young, L. J., Hunter, K. W., Hodgson, J. G., Tepper, C. G., McGoldrick, E. T., Muller, W. J., Cardiff, R. D., and Gregg, J. P. (2005) Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behavior. Clin. Exp. Metastasis 22, 47-59 (Pubitemid 41185861)
9. Ieguchi, K., Fujita, M., Ma, Z., Davari, P., Taniguchi, Y., Sekiguchi, K., Wang, B., Takada, Y. K., and Takada, Y. (2010) Direct binding of the EGF-like domain of neuregulin-1 to integrins (αvβ3 and α6β4) is involved in neuregulin-1/ErbB signaling. J. Biol. Chem. 285, 31388-31398
10. Brown, P. J., and Juliano, R. L. (1985) Selective inhibition of fibronectin-mediated cell adhesion by monoclonal antibodies to a cell-surface glycoprotein. Science 228, 1448-1451 (Pubitemid 15041325)
11. Brown, P. J., and Juliano, R. L. (1988) Monoclonal antibodies to distinctive epitopes on the α and β subunits of the fibronectin receptor. Exp. Cell Res. 177, 303-318
12. Fukazawa, H., Mizuno, S., and Uehara, Y. (1995) A microplate assay for quantitation of anchorage-independent growth of transformed cells. Anal. Biochem. 228, 83-90
13. Takagi, J., Isobe, T., Takada, Y., and Saito, Y. (1997) Structural interlock between ligand-binding site and stalk-like region of β1 integrin revealed by a monoclonal antibody recognizing conformation-dependent epitope. J. Biochem. 121, 914-921 (Pubitemid 27236910)
14. Stephenson, J. R., Axelrad, A. A., McLeod, D. L., and Shreeve, M. M. (1971) Induction of colonies of hemoglobin-synthesizing cells by erythropoietin in vitro. Proc. Natl. Acad. Sci. U.S.A. 68, 1542-1546
15. Puzon-McLaughlin, W., Kamata, T., and Takada, Y. (2000) Multiple discontinuous ligand-mimetic antibody-binding sites define a ligand-binding pocket in integrin αIIbß3. J. Biol. Chem. 275, 7795-7802 (Pubitemid 30159685)
16. Kamata, T., Tieu, K. K., Tarui, T., Puzon-McLaughlin, W., Hogg, N., and Takada, Y. (2002) The role of the CPNKEKEC sequence in the β2 subunit I domain in regulation of integrin αLβ2 (LFA-1). J. Immunol. 168, 2296-2301 (Pubitemid 34171830)
17. Doerr, M. E., and Jones, J. I. (1996) The roles of integrins and extracellular matrix proteins in the insulin-like growth factor-1-stimulated chemotaxis of human breast cancer cells. J. Biol. Chem. 271, 2443-2447
18. Lipscomb, E. A., and Mercurio, A. M. (2005) Mobilization and activation of a signaling-competent α6β4 integrin underlies its contribution to carcinoma progression. Cancer Metastasis Rev. 24, 413-423 (Pubitemid 41569981)
19. Mizushima, H., Wang, X., Miyamoto, S., and Mekada, E. (2009) Integrin signal masks growth promotion activity of HB-EGF in monolayer cell cultures. J. Cell Sci. 122, 4277-4286
20. Folkman, J., and Moscona, A. (1978) Role of cell shape in growth control. Nature 273, 345-349 (Pubitemid 8344174)
21. Jones, J. L., Royall, J. E., Critchley, D. R., and Walker, R. A. (1997) Modulation of myoepithelial-associated α6β4 integrin in a breast cancer cell line alters invasive potential. Exp. Cell Res. 235, 325-333 (Pubitemid 27398390)
22. Lu, S., Simin, K., Khan, A., and Mercurio, A. M. (2008) Analysis of integrin β4 expression in human breast cancer: association with basal-like tumors and prognostic significance. Clin. Cancer Res. 14, 1050-1058 (Pubitemid 351302550)
23. Falcioni, R., Kennel, S. J., Giacomini, P., Zupi, G., and Sacchi, A. (1986) Expression of tumor antigen correlated with metastatic potential of Lewis lung carcinoma and B16 melanoma clones in mice. Cancer Res. 46, 5772-5778 (Pubitemid 17177984)
24. Borradori, L., and Sonnenberg, A. (1999) Structure and function of hemidesmosomes: more than simple adhesion complexes. J. Invest. Dermatol. 112, 411-418 (Pubitemid 29171928)
25. Lipscomb, E. A., Dugan, A. S., Rabinovitz, I., and Mercurio, A. M. (2003) Use of RNA interference to inhibit integrin α6β4-mediated invasion and migration of breast carcinoma cells. Clin. Exp. Metastasis 20, 569-576 (Pubitemid 37297186)
26. Bon, G., Folgiero, V., Bossi, G., Felicioni, L., Marchetti, A., Sacchi, A., and Falcioni, R. (2006) Loss of β4 integrin subunit reduces the tumorigenicity of MCF-7 mammary cells and causes apoptosis upon hormone deprivation. Clin. Cancer Res. 12, 3280-3287
27. Yang, X. H., Richardson, A. L., Torres-Arzayus, M. I., Zhou, P., Sharma, C., Kazarov, A. R., Andzelm, M. M., Strominger, J. L., Brown, M., and Hemler, M. E. (2008) CD151 accelerates breast cancer by regulating α6 integrin function, signaling, and molecular organization. Cancer Res. 68, 3204-3213
28. Gambaletta, D., Marchetti, A., Benedetti, L., Mercurio, A. M., Sacchi, A., and Falcioni, R. (2000) Cooperative signaling between α6β4 integrin and ErbB2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion. J. Biol. Chem. 275, 10604-10610 (Pubitemid 30202127)
29. Guo, W., Pylayeva, Y., Pepe, A., Yoshioka, T., Muller, W. J., Inghirami, G., and Giancotti, F. G. (2006) β4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 126, 489-502 (Pubitemid 44163602)
30. Chung, J., Yoon, S. O., Lipscomb, E. A., and Mercurio, A. M. (2004) The Met receptor and α6β4 integrin can function independently to promote carcinoma invasion. J. Biol. Chem. 279, 32287-32293 (Pubitemid 39014679)
31. Yang, X., Kovalenko, O. V., Tang, W., Claas, C., Stipp, C. S., and Hemler, M. E. (2004) Palmitoylation supports assembly and function of integrintetraspanin complexes. J. Cell Biol. 167, 1231-1240 (Pubitemid 40066636)
32. Abdel-Ghany, M., Cheng, H. C., Elble, R. C., Lin, H., DiBiasio, J., and Pauli, B. U. (2003) The interacting binding domains of the β4 integrin and calcium- activated chloride channels (CLCAs) in metastasis. J. Biol. Chem. 278, 49406-49416
33. Takada, Y., and Puzon, W. (1993) Identification of a regulatory region of integrin β1 subunit using activating and inhibiting antibodies. J. Biol. Chem. 268, 17597-17601 (Pubitemid 23237006)
34. Hynes, R. O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687
35. Murgia, C., Blaikie, P., Kim, N., Dans, M., Petrie, H. T., and Giancotti, F. G. (1998) Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin β4 cytoplasmic domain. EMBO J. 17, 3940-3951 (Pubitemid 28333980)