Covalent binding of cisplatin impairs the function of Na +/K +-ATPase by binding to its cytoplasmic part

Biochemical Pharmacology

Volumn 83, Issue 11, 2012, Pages 1507-1513

  Huličiak, Miroslav ^a   Vacek, Jan ^a   Šebela, Marek ^a   Orolinová, Eva ^a   Znaleziona, Joanna ^a   Havlíková, Marika ^a   Kubala, Martin ^a  

^a PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

Cisplatin; Cysteine; Na +,K + ATPase; Nephrotoxicity; Sodium pump

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ASPARTIC ACID; CARBOPLATIN; CISPLATIN; CYSTEINE; OXALIPLATIN;

ACUTE KIDNEY FAILURE; ARTICLE; COVALENT BOND; CYTOPLASM; ELECTROCHEMISTRY; ENZYME INHIBITION; ENZYME MECHANISM; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NEPHROTOXICITY; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; STEREOSPECIFICITY;

ANIMALS; ANTINEOPLASTIC AGENTS; CEREBRAL CORTEX; CISPLATIN; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; SODIUM-POTASSIUM-EXCHANGING ATPASE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SWINE;

EID: 84859495833     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.02.015     Document Type: Article

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