Effect of the anchor in polyethylene glycol-lipids on the transfection activity of PEGylated cationic liposomes encapsulating DNA

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 4, 2012, Pages 445-448

  Kusumoto, Kenji ^a,b   Akita, Hidetaka ^a   El Sayed, Ayman ^a,c   Harashima, Hideyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

^c Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

Endosomal escape; Gene delivery; INF7; Liposome; Polyethylene glycol modified lipid

Indexed keywords

1,2 DISTEAROYL SN GLYCERO 3 PHOSPHOETHANOLAMINE N METHOXY MACROGOL 2000 MODIFIED MULTIFUNCTIONAL ENVELOPE TYPE NANODEVICE; CHOLESTEROL METHOXY MACROGOL 2000 MODIFIED MULTIFUNCTIONAL ENVELOPE TYPE NANODEVICE; DRUG CARRIER; LIPOSOME; N OCTANOYL SPHINGOSINE 1 SUCCINYL METHOXY MACROGOL 2000 MODIFIED MULTIFUNCTIONAL ENVELOPE TYPE NANODEVICE; N PALMITOYL SPHINGOSINE 1 SUCCINYL METHOXY MACROGOL 2000 MODIFIED MULTIFUNCTIONAL ENVELOPE TYPE NANODEVICE; PLASMID DNA; POLYETHYLENE GLYCOL LIPID; POLYMER; STEARYL METHOXY MACROGOL 2000 MODIFIED MULTIFUNCTIONAL ENVELOPE TYPE NANODEVICE; STEARYLATED INF7; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DNA TRANSFECTION; ENDOSOME; FETUS; GENE EXPRESSION; HYDROPHOBICITY; IN VITRO GENE TRANSFER; LIPOSOMAL GENE DELIVERY SYSTEM; LYSOSOME; MOUSE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; TRANSGENE; ZETA POTENTIAL;

ANIMALS; CELL LINE; DNA; LIPIDS; LIPOSOMES; MICE; PEPTIDES; POLYETHYLENE GLYCOLS; TRANSFECTION;

EID: 84859473119     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.35.445     Document Type: Article

References (14)

1. Khalil IA, Kogure K, Akita H, Harashima H. Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol. Rev., 58, 32-45 (2006).
2. Leventis R, Silvius JR. Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles. Biochim. Biophys. Acta, 1023, 124-132 (1990).
3. Felgner PL, Gadek TR, Holm M, Roman R, Chan HW, Wenz M, Northrop JP, Ringold GM, Danielsen M. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. U.S.A., 84, 7413-7417 (1987).
4. Mislick KA, Baldeschwieler JD. Evidence for the role of proteoglycans in cation-mediated gene transfer. Proc. Natl. Acad. Sci. U.S.A., 93, 12349-12354 (1996).
5. Kogure K, Moriguchi R, Sasaki K, Ueno M, Futaki S, Harashima H. Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method. J. Control. Release, 98, 317-323 (2004).
6. Hatakeyama H, Akita H, Kogure K, Oishi M, Nagasaki Y, Kihira Y, Ueno M, Kobayashi H, Kikuchi H, Harashima H. Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid. Gene Ther., 14, 68-77 (2007).
7. Holland JW, Cullis PR, Madden TD. Poly(ethylene glycol)-lipid conjugates promote bilayer formation in mixtures of non-bilayer-forming lipids. Biochemistry, 35, 2610-2617 (1996).
8. Meyer O, Kirpotin D, Hong K, Sternberg B, Park JW, Woodle MC, Papahadjopoulos D. Cationic liposomes coated with polyethylene glycol as carriers for oligonucleotides. J. Biol. Chem., 273, 15621-15627 (1998).
9. Woodle MC. Controlling liposome blood clearance by surface-grafted polymers. Adv. Drug Deliv. Rev., 32, 139-152 (1998).
10. Song LY, Ahkong QF, Rong Q, Wang Z, Ansell S, Hope MJ, Mui B. Characterization of the inhibitory effect of PEG-lipid conjugates on the intracellular delivery of plasmid and antisense DNA mediated by cationic lipid liposomes. Biochim. Biophys. Acta, 1558, 1-13 (2002).
11. El-Sayed A, Masuda T, Khalil I, Akita H, Harashima H. Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape. J. Control. Release, 138, 160-167 (2009).
12. Ambegia E, Ansell S, Cullis P, Heyes J, Palmer L, MacLachlan I. Stabilized plasmid-lipid particles containing PEG-diacylglycerols exhibit extended circulation lifetimes and tumor selective gene expression. Biochim. Biophys. Acta, 1669, 155-163 (2005).
13. Zhao XB, Muthusamy N, Byrd JC, Lee RJ. Cholesterol as a bilayer anchor for PEGylation and targeting ligand in folate-receptor-targeted liposomes. J. Pharm. Sci., 96, 2424-2435 (2007).
14. Carrion C, Domingo JC, de Madariaga MA. Preparation of long-circulating immunoliposomes using PEG-cholesterol conjugates: effect of the spacer arm between PEG and cholesterol on liposomal characteristics. Chem. Phys. Lipids, 113, 97-110 (2001).