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Volumn 19, Issue 2, 2012, Pages 1-8

EGFR tyrosine kinase mutation testing in the treatment of non-small-cell lung cancer

Author keywords

Epidermal growth factor receptor; Erlotinib; Gefitinib; Genetic testing; Non small cell lung cancer

Indexed keywords

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; ENZYME ASSAY; EPIDERMAL GROWTH FACTOR RECEPTOR 1 GENE; EPIDERMAL GROWTH FACTOR RECEPTOR 10 GENE; EPIDERMAL GROWTH FACTOR RECEPTOR 11 GENE; EPIDERMAL GROWTH FACTOR RECEPTOR 12 GENE; EPIDERMAL GROWTH FACTOR RECEPTOR 13 GENE; EPIDERMAL GROWTH FACTOR RECEPTOR 2 GENE; EPIDERMAL GROWTH FACTOR RECEPTOR 3 GENE; EPIDERMAL GROWTH FACTOR RECEPTOR 4 GENE; EPIDERMAL GROWTH FACTOR RECEPTOR 5 GENE; EPIDERMAL GROWTH FACTOR RECEPTOR 6 GENE; EPIDERMAL GROWTH FACTOR RECEPTOR 7 GENE; EPIDERMAL GROWTH FACTOR RECEPTOR 8 GENE; EPIDERMAL GROWTH FACTOR RECEPTOR 9 GENE; EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE GENE; EXON; GENE DELETION; GENETIC SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MUTATIONAL ANALYSIS; MUTATOR GENE; PROCESS OPTIMIZATION; RECEPTOR GENE; SENSITIVITY AND SPECIFICITY; VALIDATION STUDY;

EID: 84859458169     PISSN: None     EISSN: 17187729     Source Type: Journal    
DOI: 10.3747/co.19.862     Document Type: Article
Times cited : (16)

References (32)
  • 2
    • 33847276516 scopus 로고    scopus 로고
    • Randomized phase iii study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: Four-Arm Cooperative Study in Japan
    • Ohe Y, Ohashi Y, Kubota K, et al. Randomized phase iii study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: Four-Arm Cooperative Study in Japan. Ann Oncol 2007;18:317-23.
    • (2007) Ann Oncol , vol.18 , pp. 317-323
    • Ohe, Y.1    Ohashi, Y.2    Kubota, K.3
  • 3
    • 0042413836 scopus 로고    scopus 로고
    • Randomized, multinational, phase iii study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for advanced non-small-cell lung cancer: The TAX 326 study group
    • Fossella F, Pereira JR, von Pawel J, et al. Randomized, multinational, phase iii study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for advanced non-small-cell lung cancer: the TAX 326 study group. J Clin Oncol 2003;21:3016-24.
    • (2003) J Clin Oncol , vol.21 , pp. 3016-3024
    • Fossella, F.1    Pereira, J.R.2    von Pawel, J.3
  • 4
    • 0035397994 scopus 로고    scopus 로고
    • Randomized phase iii trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small-cell lung cancer: A Southwest Oncology Group trial
    • Kelly K, Crowley J, Bunn PA Jr, et al. Randomized phase iii trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small-cell lung cancer: a Southwest Oncology Group trial. J Clin Oncol 2001;19:3210-18.
    • (2001) J Clin Oncol , vol.19 , pp. 3210-3218
    • Kelly, K.1    Crowley, J.2    Bunn Jr., P.A.3
  • 5
    • 49049089802 scopus 로고    scopus 로고
    • Phase iii study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
    • Scagliotti GV, Parikh P, von Pawel J, et al. Phase iii study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008;26:3543-51.
    • (2008) J Clin Oncol , vol.26 , pp. 3543-3551
    • Scagliotti, G.V.1    Parikh, P.2    von Pawel, J.3
  • 6
    • 0037050352 scopus 로고    scopus 로고
    • Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
    • Schiller JH, Harrington D, Belani CP, et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 2002;346:92-8.
    • (2002) N Engl J Med , vol.346 , pp. 92-98
    • Schiller, J.H.1    Harrington, D.2    Belani, C.P.3
  • 7
    • 25444505624 scopus 로고    scopus 로고
    • Epidermal growth factor-independent transformation of Ba/ F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression
    • Jiang J, Greulich H, Jänne PA, Sellers WR, Meyerson M, Griffin JD. Epidermal growth factor-independent transformation of Ba/ F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression. Cancer Res 2005;65:8968-74.
    • (2005) Cancer Res , vol.65 , pp. 8968-8974
    • Jiang, J.1    Greulich, H.2    Jänne, P.A.3    Sellers, W.R.4    Meyerson, M.5    Griffin, J.D.6
  • 8
    • 20244389188 scopus 로고    scopus 로고
    • Predictive and prognostic impact of epidermal growth factor receptor mutation in nonsmall- cell lung cancer patients treated with gefitinib
    • Han SW, Kim TY, Hwang PG, et al. Predictive and prognostic impact of epidermal growth factor receptor mutation in nonsmall- cell lung cancer patients treated with gefitinib. J Clin Oncol 2005;23:2493-501.
    • (2005) J Clin Oncol , vol.23 , pp. 2493-2501
    • Han, S.W.1    Kim, T.Y.2    Hwang, P.G.3
  • 9
    • 70350493524 scopus 로고    scopus 로고
    • First-line gefitinib versus first-line chemotherapy by carboplatin (cbdca) plus paclitaxel (txl) in non-small cell lung cancer (nsclc) patients (pts) with efgr mutations: A phase iii study (002) by North EastJapan Gefitinib Study Group [abstract 8016]
    • Available online at, citedFebruary 3,2012
    • Kobayashi K, Inoue A, Maemondo M, et al. First-line gefitinib versus first-line chemotherapy by carboplatin (cbdca) plus paclitaxel (txl) in non-small cell lung cancer (nsclc) patients (pts) with efgr mutations: a phase iii study (002) by North EastJapan Gefitinib Study Group [abstract 8016]. J Clin Oncol 2009;27:. [Available online at: http://www.asco.org/ASCOv2/ Meetings/Abstracts?&vmview=abst_detail_view&confID=65 &abstractID=31299; cited February 3, 2012]
    • (2009) J Clin Oncol , vol.27
    • Kobayashi, K.1    Inoue, A.2    Maemondo, M.3
  • 10
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 11
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin- paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin- paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361:947-57.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 12
    • 84887212361 scopus 로고    scopus 로고
    • Alterations in genes of the efgr signaling pathway and their relationship to efgr tyrosine kinase inhibitor sensitivity in lung cancer cell lines
    • Gandhi J, Zhang J, Xie Y, et al. Alterations in genes of the efgr signaling pathway and their relationship to efgr tyrosine kinase inhibitor sensitivity in lung cancer cell lines. PLoS One 2009;4:e4576.
    • (2009) PLoS One , vol.4
    • Gandhi, J.1    Zhang, J.2    Xie, Y.3
  • 13
    • 4444344330 scopus 로고    scopus 로고
    • Egf receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumours to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M, et al. egf receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumours to gefitinib and erlotinib. Proc Natl Acad Sci U S A 2004;101:13306-11.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 14
    • 2342624080 scopus 로고    scopus 로고
    • EFGR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Jänne PA, Lee JC, et al. EFGR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304:1497-500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Jänne, P.A.2    Lee, J.C.3
  • 15
    • 77951951659 scopus 로고    scopus 로고
    • Clinical outcomes in non-small-cell lung cancer patients with EFGR mutations: Pooled analysis
    • Paz-Ares L, Soulières D, Melezínek I, et al. Clinical outcomes in non-small-cell lung cancer patients with EFGR mutations: pooled analysis. J Cell Mol Med 2010;14:51-69.
    • (2010) J Cell Mol Med , vol.14 , pp. 51-69
    • Paz-Ares, L.1    Soulières, D.2    Melezínek, I.3
  • 16
    • 0036213267 scopus 로고    scopus 로고
    • Methods of molecular analysis: Mutation detection in solid tumours
    • Frayling IM. Methods of molecular analysis: mutation detection in solid tumours. Mol Pathol 2002;55:73-9.
    • (2002) Mol Pathol , vol.55 , pp. 73-79
    • Frayling, I.M.1
  • 17
    • 0030791025 scopus 로고    scopus 로고
    • Methods for detection of point mutations: Performance and quality assessment. ifcc Scientific Division, Committee on Molecular Biology Techniques
    • Nollau P, Wagener C. Methods for detection of point mutations: performance and quality assessment. ifcc Scientific Division, Committee on Molecular Biology Techniques. Clin Chem 1997;43:1114-28.
    • (1997) Clin Chem , vol.43 , pp. 1114-1128
    • Nollau, P.1    Wagener, C.2
  • 18
    • 0030777020 scopus 로고    scopus 로고
    • Genotypic selection methods for the direct analysis of point mutations
    • Parsons BL, Heflich RH. Genotypic selection methods for the direct analysis of point mutations. Mutat Res 1997;387:97-121.
    • (1997) Mutat Res , vol.387 , pp. 97-121
    • Parsons, B.L.1    Heflich, R.H.2
  • 19
    • 64149103904 scopus 로고    scopus 로고
    • Pcr-based methods for the enrichment of minority alleles and mutations
    • Milbury CA, Li J, Makrigiorgos GM. pcr-based methods for the enrichment of minority alleles and mutations. Clin Chem 2009;55:632-40.
    • (2009) Clin Chem , vol.55 , pp. 632-640
    • Milbury, C.A.1    Li, J.2    Makrigiorgos, G.M.3
  • 21
    • 45149084723 scopus 로고    scopus 로고
    • First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic efgr mutations
    • Sequist LV, Martins RG, Spigel D, et al. First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic efgr mutations. J Clin Oncol 2008;26:2442-9.
    • (2008) J Clin Oncol , vol.26 , pp. 2442-2449
    • Sequist, L.V.1    Martins, R.G.2    Spigel, D.3
  • 22
    • 84859422412 scopus 로고    scopus 로고
    • Updated efficacy and qualityof- life (qol) analyses in optimal, a phase iii, randomized, open-label study of first-line erlotinib versus gemcitabine/ carboplatin in patients with EGFR-activating mutation-positive (EGFR Act Mut+) advanced non-small cell lung cancer (nsclc) [abstract 7520]
    • Available online at
    • Zhou C, Wu YL, Chen G, et al. Updated efficacy and qualityof- life (qol) analyses in optimal, a phase iii, randomized, open-label study of first-line erlotinib versus gemcitabine/ carboplatin in patients with EGFR-activating mutation-positive (EGFR Act Mut+) advanced non-small cell lung cancer (nsclc) [abstract 7520]. J Clin Oncol 2011;29:. [Available online at: ht tp://www.asco.org/ASCOv2/Meetings/ Abstracts?&vmview=abst_detail_view&conf ID=102&abstractID=81408; cited February 3, 2012]
    • (2011) J Clin Oncol , vol.29
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3
  • 23
    • 80053561215 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy (ct) in advanced non-small cell lung cancer (nsclc) patients (p) with epidermal growth factor receptor (efgr) mutations: Interim results of the European Erlotinib Versus Chemotherapy (eurtac) phase iii randomized trial [abstract 7503]
    • Available online at, citedFebruary 3,2012
    • Rosell R, Gervais R, Vergnenegre A, et al. Erlotinib versus chemotherapy (ct) in advanced non-small cell lung cancer (nsclc) patients (p) with epidermal growth factor receptor (efgr) mutations: interim results of the European Erlotinib Versus Chemotherapy (eurtac) phase iii randomized trial [abstract 7503]. J Clin Oncol 2011;29:. [Available online at: ht tp://www.asco.org/ASCOv2/Meet ings/abst racts? &vmview=abst_detail_view&conf ID=102&abstract ID=78285; cited February 3, 2012]
    • (2011) J Clin Oncol , vol.29
    • Rosell, R.1    Gervais, R.2    Vergnenegre, A.3
  • 24
    • 43249096031 scopus 로고    scopus 로고
    • Structure and clinical relevance of the epidermal growth factor receptor in human cancer
    • Kumar A, Petri ET, Halmos B, Boggon TJ. Structure and clinical relevance of the epidermal growth factor receptor in human cancer. J Clin Oncol 2008;26:1742-51.
    • (2008) J Clin Oncol , vol.26 , pp. 1742-1751
    • Kumar, A.1    Petri, E.T.2    Halmos, B.3    Boggon, T.J.4
  • 25
    • 28844501639 scopus 로고    scopus 로고
    • Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers
    • Shigematsu H, Gazdar AF. Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. Int J Cancer 2006;118:257-62.
    • (2006) Int J Cancer , vol.118 , pp. 257-262
    • Shigematsu, H.1    Gazdar, A.F.2
  • 26
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinibsensitizing EFGR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella R, Bell DW, Haber DA, Settleman J. Gefitinibsensitizing EFGR mutations in lung cancer activate anti-apoptotic pathways. Science 2004;305:1163-7.
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 27
    • 28444478439 scopus 로고    scopus 로고
    • Oncogenic transformation by inhibitor-sensitive and -resistant EFGR mutants
    • Greulich H, Chen TH, Feng W, et al. Oncogenic transformation by inhibitor-sensitive and -resistant EFGR mutants. PLoS Med 2005;2:e313.
    • (2005) PLoS Med , vol.2
    • Greulich, H.1    Chen, T.H.2    Feng, W.3
  • 29
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • Weinstein IB, Joe A. Oncogene addiction. Cancer Res 2008;68:3077-80.
    • (2008) Cancer Res , vol.68 , pp. 3077-3080
    • Weinstein, I.B.1    Joe, A.2
  • 30
    • 54549094903 scopus 로고    scopus 로고
    • Somatic mutations affect key pathways in lung adenocarcinoma
    • Ding L, Getz G, Wheeler DA, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008;455:1069-75.
    • (2008) Nature , vol.455 , pp. 1069-1075
    • Ding, L.1    Getz, G.2    Wheeler, D.A.3
  • 31
    • 23844544647 scopus 로고    scopus 로고
    • Rapid polymerase chain reactionbased detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas
    • Pan Q, Pao W, Ladanyi M. Rapid polymerase chain reactionbased detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas. J Mol Diagn 2005;7:396-403.
    • (2005) J Mol Diagn , vol.7 , pp. 396-403
    • Pan, Q.1    Pao, W.2    Ladanyi, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.