Vitamin B 12 supplementation improves heart rate variability in healthy elderly Indian subjects

Autonomic Neuroscience: Basic and Clinical

Volumn 168, Issue 1-2, 2012, Pages 66-71

  Sucharita, S ^a   Thomas, T ^a   Antony, B ^a   Vaz, M ^a  

^a ST JOHN'S NATIONAL ACADEMY OF HEALTH SCIENCES   (India)

Author keywords

Autonomic nervous system; Elderly; Healthy; Heart rate variability; Supplementation; Vitamin B 12

Indexed keywords

CYANOCOBALAMIN; VITAMIN;

ADULT; AGED; ANTHROPOMETRY; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; BLOOD SAMPLING; FEMALE; HEART RATE VARIABILITY; HUMAN; INDIAN; MAJOR CLINICAL STUDY; MALE; NERVE CONDUCTION; PARASYMPATHETIC FUNCTION; PRIORITY JOURNAL; SYMPATHETIC FUNCTION; VITAMIN SUPPLEMENTATION; AUTONOMIC NERVOUS SYSTEM; BLOOD; CYANOCOBALAMIN DEFICIENCY; DIET SUPPLEMENTATION; DRUG EFFECT; HEART; HEART RATE; INDIA; INNERVATION; MIDDLE AGED; NEUROLOGIC EXAMINATION; PATHOPHYSIOLOGY; PERIPHERAL NERVE; PHYSIOLOGY;

AGED; ANTHROPOMETRY; AUTONOMIC NERVOUS SYSTEM; DIETARY SUPPLEMENTS; FEMALE; HEART; HEART RATE; HUMANS; INDIA; MALE; MIDDLE AGED; NEURAL CONDUCTION; NEUROLOGIC EXAMINATION; PERIPHERAL NERVES; VITAMIN B 12; VITAMIN B 12 DEFICIENCY; VITAMINS;

EID: 84859435778     PISSN: 15660702     EISSN: 18727484     Source Type: Journal    
DOI: 10.1016/j.autneu.2011.12.002     Document Type: Article

References (43)

1. 12 deficiency. Muscle Nerve 1998, 21(10):1341-1343.
2. Antony A.C. Prevalence of cobalamin (vitamin B-12) and folate deficiency in India-audi alteram partem. Am. J. Clin. Nutr. 2001, 74:157-159.
3. 12 deficiency by power spectral analysis of heart rate variability. Pacing Clin. Electrophysiol. 2000, 23:975-978.
4. 12 deficiency. Auton. Neurosci. 2002, 97(1):45-54.
5. Dali-Youcef N., Andres E. An update on cobalamin deficiency in adults. QJM 2009, 102:17-28.
6. Desai H.G., Gupte P.A. Helicobacter pylori link to pernicious anaemia. J. Assoc. Physicians India 2007, 55:857-859.
7. Durnin J.V.G.A., Womersley J. Estimates of total body fat from skinfold thickness: measurements on 481 men and women aged from 16 to 72years. Br. J. Nutr. 1974, 32:77-79.
8. Eisenhofer G., Lambie D.G., Johnson R.H., Tan E., Whiteside E.A. Deficient catecholamine release as the basis of orthostatic hypotension in pernicious anaemia. J. Neurol. Neurosurg. Psychiatry 1982, 45:1053-1055.
9. Esler M.D., Thompson J.M., Kaye D.M., Turner A.G., Jennings G.L., Cox H.S., Lambert G.W., Seals D.R. Effects of aging on the responsiveness of the human cardiac sympathetic nerves to stressors. Circulation 1995, 91(2):351-358.
10. 12 deficiency: a dose-finding trial. Arch. Intern. Med. 2005, 165:1167-1172.
11. Falco F.J.E., Hennessey W.J., Braddom R.L., Goldberg G. Standardised nerve conduction tests in the upper limb of elderly subjects. Am. J. Phys. Med. Rehabil. 1992, 71:263-271.
12. 12 deficiency and incontinence in older people. Can. J. Urol. 2000, 7(4):1077-1080.
13. Green R. Is it time for vitamin B-12 fortification? What are the questions?. Am. J. Clin. Nutr. 2009, 89(Suppl 1):712S-716S.
14. Gupta V., Lipsitz L.A. Orthostatic hypotension in the elderly: diagnosis and treatment. Am. J. Med. 2007, 120:841-847.
15. Hoeldtke R.D., Cilmi K.M. Effects of aging on catecholamine metabolism. J. Clin. Endocrinol. Metab. 1985, 60(3):479-484.
16. Hunt B.E., Farquhar W.B., Taylor J.A. Does reduces vascular stiffening fully explain preserved cardiovagal baroreflex function in older, physically active men?. Circulation 2001, 103(20):2424-2427.
17. Ingall T.J., McLeod J.G., O'Brien P.C. The effect of ageing on autonomic nervous system function. Aust. N. Z. J. Med. 1990, 20(4):570-577.
18. Kimura J. Principles and pitfalls of nerve conduction studies. Ann. Neurol. 1984, 16:415-429.
19. Lindenbaum J., Rosenberg I.H., Wilson P.W.F., Stabler S.P., Allen R.H. Prevalence of cobalamin deficiency in the Framingham elderly population. Am. J. Clin. Nutr. 1994, 60:2-11.
20. Makharia G.K. Where are adult Indian celiacs?. Trop. Gastroenterol. 2006, 27:1-3.
21. 12 deficiency. J. Neurol. Sci. 1984, 66(1):117-126.
22. Metz J. Cobalamin deficiency and the pathogenesis of nervous system disease. Annu. Rev. Nutr. 1992, 12:59-79.
23. 12 replacement. Clin. Auton. Res. 2004, 14(2):67-71.
24. Namer B., Barta B., Ørstavik K., Schmidt R., Carr R., Schmelz M., Handwerker H.O. Microneurographic assessment of C-fibre function in aged healthy subjects. J. Physiol. 2009, 587:419-428.
25. National Nutrition Monitoring Bureau Report of Repeat Survey Phase I, Table 6 1989, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.
26. Nelson J.M. Vitamin B12 deficiency in the elderly. A major contributor to falls. Adv. Nurse Pract. 2001, 9(11):39-41.
27. O'Broin S.D., Kelleher B.P., Davoren A., Gunter E.W. Field study screening of blood folate concentrations: specimen stability and finger-stick sampling. Am. J. Clin. Nutr. 1997, 66:1398-1405.
28. Raimondi G., Legramante J.M., Iellamo F., Micozzi F., Sacco S., Balocchi R., Chillemi S., Peruzzi G. Effect of aging on responses to autonomic cardiovascular tests. J. Gravit. Physiol. 1999, 6(1):P141-P142.
29. 12, folic acid, and the nervous system. Lancet Neurol. 2006, 5(11):949-960.
30. Routledge H.C., Chowdhary S., Townend J.N. Heart rate variability-a therapeutic target?. J. Clin. Pharm. Ther. 2002, 27:85-92.
31. Seals D.R., Esler M.D. Human ageing and the sympathoadrenal system. J. Physiol. 2000, 528:407-417.
32. Skrabal F. Syncope, falls and cobalamin deficiency in the old population. Clin. Auton. Res. 2004, 14(2):60-66.
33. 12 deficiency: a heart rate variability study. J. Auton. Nerv. Syst. 1998, 71:25-27.
34. 12 deficiency as a worldwide problem. Annu. Rev. Nutr. 2004, 24:299-326.
35. Stephen J.M., Ranken D., Best E., Adair J., Knoefel J., Kovacevic S., Padilla D., Hart B., Aine C.J. Aging changes and gender differences in response to median nerve stimulation measured with MEG. Clin. Neurophysiol. 2006, 17(1):131-143.
36. Sucharita S., Bharathi A.V., Kurpad A.V., Vaz M. A comparative study of tests of cardiac parasympathetic nervous activity in healthy human subjects. Physiol. Meas. 2002, 23:347-354.
37. Tasaki H., Serita T., Irita A., Hano O., Iliev I., Ueyama C., Kitano K., Seto S., Hayano M., Yano K. A 15-year longitudinal follow-up study of heart rate and heart rate variability in healthy elderly persons. J. Gerontol. A Biol. Sci. Med. Sci. 2000, 55(12):M744-M749.
38. Task Force of the European Society of Cardiology and the North American Society of Pacing and electrophysiology Heart rate variability, standards of measurement, physiological interpretation and clinical use. Circulation 1996, 93:1043-1065.
39. 12 deficiency. J. Neurol. Neurosurg. Psychiatry 1999, 66(6):804-805.
40. Tsuji H., Venditti F.J., Manders E.S., Evans J.C., Larson M.G., Feldman C.L., Levy D. Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation 1994, 90:878-883.
41. Vaz M., Cox H.S., Kaye D.M., Turner A.G., Jennings G.L., Esler M.D. Fallibility of plasma noradrenaline measurements in studying postprandial sympathetic nervous responses. J. Auton. Nerv. Syst. 1995, 56(1-2):97-104.
42. Vinik A.I., Maserm R.E., Mitchell B.D., Freeman R. Diabetic autonomic neuropathy. Diabetes Care 2003, 26(5):1553-1579.
43. White W.B., Reik L., Cutlip D.E. Pernicious anemia seen initially as orthostatic hypotension. Arch. Intern. Med. 1981, 14(11):1543-1544.