Modification of the C16Y peptide on nanoparticles is an effective approach to target endothelial and cancer cells via the integrin receptor

International Journal of Pharmaceutics

Volumn 428, Issue 1-2, 2012, Pages 114-117

  Hamano, Nobuhito ^a   Negishi, Yoichi ^a   Fujisawa, Azusa ^a   Manandhar, Maya ^a   Sato, Hinako ^a   Katagiri, Fumihiko ^a   Nomizu, Motoyoshi ^a   Aramaki, Yukihiko ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Liposomes, Integrin, Peptide, Tumor targeting

Indexed keywords

ALPHAVBETA1 INTEGRIN; C16Y PEPTIDE; INTEGRIN; LIPOSOME; PEPTIDE; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ANIMAL CELL; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG UPTAKE; ENDOCYTOSIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TEMPERATURE SENSITIVITY;

ANIMALS; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; ENDOTHELIAL CELLS; GENE TRANSFER TECHNIQUES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTEGRIN ALPHA5BETA1; INTEGRIN ALPHAVBETA3; LIPOSOMES; MELANOMA, EXPERIMENTAL; MICE; NANOPARTICLES; OLIGOPEPTIDES; POLYETHYLENE GLYCOLS;

EID: 84859426401     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.02.006     Document Type: Article

References (7)

1. H. Hatakeyama, H. Akita, E. Ishida, K. Hashimoto, H. Kobayashi, T. Aoki, J. Yasuda, K. Obata, H. Kikuchi, T. Ishida, H. Kiwada, and H. Harashima Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes Int. J. Pharm. 342 2007 194 200 (Pubitemid 47259319)
2. H. Kim, and K.G. Csaky Nanoparticle-integrin antagonist C16Y peptide treatment of choroidal neovascularization in rats J. Control. Release 142 2010 286 293
3. H. Maeda, J. Wu, T. Sawa, Y. Matsumura, and K. Hori Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review J. Control. Release 65 2000 271 284 (Pubitemid 30122932)
4. M.L. Ponce, M. Nomizu, and H.K. Kleinman An angiogenic laminin site and its antagonist bind through the alpha(v)beta3 and alpha5beta1 integrins FASEB J. 15 2001 1389 1397 (Pubitemid 32531816)
5. M.L. Ponce, S. Hibino, A.M. Lebioda, M. Mochizuki, M. Nomizu, and H.K. Kleinman Identification of a potent peptide antagonist to an active laminin-1 sequence that blocks angiogenesis and tumor growth Cancer Res. 63 2003 5060 5064 (Pubitemid 37022645)
6. R. Suzuki, T. Takizawa, Y. Kuwata, M. Mutoh, N. Ishiguro, N. Utoguchi, A. Shinohara, M. Eriguchi, H. Yanagie, and K. Maruyama Effective anti-tumor activity of oxaliplatin encapsulated in transferrin-PEG-liposome Int. J. Pharm. 346 2008 143 150 (Pubitemid 350101994)
7. G. Xiang, J. Wu, Y. Lu, Z. Liu, and R.J. Lee Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes Int. J. Pharm. 356 2008 29 36