Association between central nervous system drugs and recurrent falling based on prospective falls registration in nursing homes

European Geriatric Medicine

Volumn 3, Issue 2, 2012, Pages 82-86

  Szczerbinska K ^a   Topor Mdry R ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Antiepileptics; CNS drugs; Drugs; Nursing home; Recurrent falls

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; ANALGESIC AGENT; ANTIDEPRESSANT AGENT; ANTIPARKINSON AGENT; CARBAMAZEPINE; CENTRAL NERVOUS SYSTEM AGENTS; CHLORPROMAZINE; CHOLINESTERASE INHIBITOR; CLONAZEPAM; HYPNOTIC AGENT; NEUROLEPTIC AGENT; NOOTROPIC AGENT; PHENOBARBITAL; PHENYTOIN; PSYCHOSTIMULANT AGENT; TIAGABINE; TOPIRAMATE; VALPROIC ACID; XANTHINE DERIVATIVE;

AGED; CHRONIC PATIENT; COHORT ANALYSIS; CONFERENCE PAPER; CONFIDENCE INTERVAL; CONTROLLED STUDY; DEMENTIA; DRUG USE; FALL RISK ASSESSMENT; FALLING; FEMALE; GENDER; GERIATRIC PATIENT; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MENTAL PATIENT; NURSING HOME PATIENT; OBSERVATIONAL STUDY; PATIENT CARE; POISSON DISTRIBUTION; POLAND; PRIORITY JOURNAL; REGISTRATION; SIDE EFFECT; UNIVARIATE ANALYSIS;

EID: 84859422243     PISSN: 18787649     EISSN: 18787657     Source Type: Journal    
DOI: 10.1016/j.eurger.2011.12.007     Document Type: Conference Paper

References (34)

1. T.S. Field, J.H. Gurwitz, J. Avorn, D. McCormick, S. Jain, and M. Eckler Risk factors for adverse drug events among nursing home residents Arch Intern Med 161 13 2001 1629 1634
2. R.M. Leipzig, R.G. Cumming, and M.E. Tinetti Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs J Am Geriatr Soc 47 1 1999 30 39
3. S. Hartikainen, E. Lonnroos, and K. Louhivuori Medication as a risk factor for falls: critical systematic review J Gerontol A Biol Sci Med Sci 62 10 2007 1172 1181
4. A.M. Tromp, S.M. Pluijm, J.H. Smit, D.J. Deeg, L.M. Bouter, and P. Lips Fall-risk screening test: a prospective study on predictors for falls in community-dwelling elderly J Clin Epidemiol 54 8 2001 837 844
5. J.C. Woolcott, K.J. Richardson, M.O. Wiens, B. Patel, J. Marin, and K.M. Khan Meta-analysis of the impact of 9 medication classes on falls in elderly persons Arch Intern Med 169 21 2009 1952 1960
6. P.A. Stalenhoef, J.P. Diederiks, J.A. Knottnerus, L.P. de Witte, and H.F. Crebolder The construction of a patient record-based risk model for recurrent falls among elderly people living in the community Fam Pract 17 6 2000 490 496
7. H. Luukinen, K. Koski, P. Laippala, and S.L. Kivela Predictors for recurrent falls among the home-dwelling elderly Scand J Prim Health Care 13 4 1995 294 299
8. K.E. Ensrud, T.L. Blackwell, C.M. Mangione, P.J. Bowman, M.A. Whooley, and D.C. Bauer Central nervous system-active medications and risk for falls in older women J Am Geriatr Soc 50 10 2002 1629 1637
9. D.A. Lawlor, R. Patel, and S. Ebrahim Association between falls in elderly women and chronic diseases and drug use: cross sectional study BMJ 327 7417 2003 712 717
10. A. Rossat, B. Fantino, B. Bongue, A. Colvez, C. Nitenberg, and C. Annweiler Association between benzodiazepines and recurrent falls: a cross-sectional elderly population-based study J Nutr Health Aging 15 1 2011 72 77
11. Y.B. Yip, and R.G. Cumming The association between medications and falls in Australian nursing-home residents Med J Aust 160 1 1994 14 18
12. F. Landi, G. Onder, M. Cesari, C. Barillaro, A. Russo, and R. Bernabei Psychotropic medications and risk for falls among community-dwelling frail older people: an observational study J Gerontol A Biol Sci Med Sci 60 5 2005 622 626
13. D.D. French, D.C. Werner, R.R. Campbell, G.M. Powell-Cope, A.L. Nelson, and L.Z. Rubenstein A multivariate fall risk assessment model for VHA nursing homes using the minimum data set J Am Med Dir Assoc 8 2 2007 115 122
14. L.A. Lipsitz, P.V. Jonsson, M.M. Kelley, and J.S. Koestner Causes and correlates of recurrent falls in ambulatory frail elderly J Gerontol 46 4 1991 M114 M122
15. P.B. Thapa, P. Gideon, R.L. Fought, and W.A. Ray Psychotropic drugs and risk of recurrent falls in ambulatory nursing home residents Am J Epidemiol 142 2 1995 202 211
16. H. Luukinen, K. Koski, P. Laippala, and S.L. Kivela Risk factors for recurrent falls in the elderly in long-term institutional care Public Health 109 1 1995 57 65
17. C.L. Arfken, J.G. Wilson, and S.M. Aronson Retrospective review of selective serotonin reuptake inhibitors and falling in older nursing home residents Int Psychogeriatr 13 1 2001 85 91
18. K. Kallin, Y. Gustafson, P.O. Sandman, and S. Karlsson Drugs and falls in older people in geriatric care settings Aging Clin Exp Res 16 4 2004 270 276
19. C.I. Neutel, S. Perry, and C. Maxwell Medication use and risk of falls Pharmacoepidemiol Drug Saf 11 2 2002 97 104
20. A.Y. Avidan, B.E. Fries, M.L. James, K.L. Szafara, G.T. Wright, and R.D. Chervin Insomnia and hypnotic use, recorded in the minimum data set, as predictors of falls and hip fractures in Michigan nursing homes J Am Geriatr Soc 53 6 2005 955 962
21. T.T. Hien le, R.G. Cumming, I.D. Cameron, J.S. Chen, S.R. Lord, and L.M. March Atypical antipsychotic medications and risk of falls in residents of aged care facilities J Am Geriatr Soc 53 8 2005 1290 1295
22. K. Hauer, S.E. Lamb, E.C. Jorstad, C. Todd, C. Becker PROFANE-Group Systematic review of definitions and methods of measuring falls in randomised controlled fall prevention trials Age Ageing 35 1 2006 5 10
23. American Geriatrics Society, British Geriatrics Society, and American Academy of Orthopaedic Surgeons Panel on Falls Prevention Guideline for the prevention of falls in older persons J Am Geriatr Soc 49 5 2001 664 672
24. L.Z. Rubenstein, C.M. Powers, and C.H. MacLean Quality indicators for the management and prevention of falls and mobility problems in vulnerable elders Ann Intern Med 135 8 Pt 2 2001 686 693
25. Clinical practice guidelines for assessment and prevention of falls in older people. National Institute of Clinical Excellence (NICE), London, Nov. 2004.
26. P.B. Thapa, P. Gideon, T.W. Cost, A.B. Milam, and W.A. Ray Antidepressants and the risk of falls among nursing home residents N Engl J Med 339 13 1998 875 882
27. A. Darowski, S.A. Chambers, and D.J. Chambers Antidepressants and falls in the elderly Drugs Aging 26 5 2009 381 394
28. P. Vestergaard, L. Rejnmark, and L. Mosekilde Anxiolytics, sedatives, antidepressants, neuroleptics and the risk of fracture Osteoporos Int 17 6 2006 807 816
29. W.A. Ray, M.R. Griffin, and E. Malcolm Cyclic antidepressants and the risk of hip fracture Arch Intern Med 151 4 1991 754 756
30. C.S. Sterke, A.P. Verhagen, E.F. van Beeck, and T.J. van der Cammen The influence of drug use on fall incidents among nursing home residents: a systematic review Int Psychogeriatr 20 5 2008 890 910
31. M.C. Nevitt, S.R. Cummings, S. Kidd, and D. Black Risk factors for recurrent nonsyncopal falls. A prospective study JAMA 261 18 1989 2663 2668
32. K.D. Kelly, W. Pickett, N. Yiannakoulias, B.H. Rowe, D.P. Schopflocher, and L. Svenson Medication use and falls in community-dwelling older persons Age Ageing 32 5 2003 503 509
33. J.T. Hanlon, R.M. Boudreau, Y.F. Roumani, A.B. Newman, C.M. Ruby, and R.M. Wright Number and dosage of central nervous system medications on recurrent falls in community elders: the Health, Aging and Body Composition study J Gerontol A Biol Sci Med Sci 64 4 2009 492 498
34. Sterke CS, van Beeck EF, van der Velde N, Ziere G, Petrovic M, Looman CW, et al. New insights: dose-response relationship between psychotropic drugs and falls: a study in nursing home residents with dementia. J Clin Pharmacol 2011, doi:10.1177/0091270011405665 (accessed on 14th November 2011).