A composite computational model of liver glucose homeostasis. I. Building the composite model

Journal of the Royal Society Interface

Volumn 9, Issue 69, 2012, Pages 689-700

  Hetherington, J ^a,b   Sumner, T ^a,c   Seymour, R M ^a   Li, L ^a,d   Varela Rey, M ^a,e   Yamaji, S ^a,f   Saffrey, P ^a,g   Margoninski, O ^a,h   Bogle, I D L ^a   Finkelstein, A ^a   Warner, A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b AMEE UK Ltd   (United Kingdom)

^c INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^d INSTITUTE FOR ENERGY TECHNOLOGY   (Norway)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

^f BURNHAM INSTITUTE   (United States)

^g WESTERN INFIRMARY   (United Kingdom)

^h Verisign   (Switzerland)

Author keywords

Computational modelling; Glucose homeostasis; Liver; Systems biology

Indexed keywords

COMPUTATIONAL METHODS; GLUCOSE; LIVER; PHYSIOLOGY;

COMPLEX COMPOSITES; COMPONENT MODEL; COMPOSITE MODELS; COMPUTATIONAL FRAMEWORK; COMPUTATIONAL MODEL; COMPUTATIONAL MODELLING; GLUCOSE HOMEOSTASIS; IN-VITRO; INDIVIDUAL MODELS; MODEL PARAMETERS; MODELLING SOFTWARES; MOLECULAR-BIOLOGICAL TECHNIQUES; PHYSIOLOGICAL DATA; SYSTEMS BIOLOGY;

MODELS;

CALCIUM; G PROTEIN COUPLED RECEPTOR; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3; PHOSPHOLIPASE C;

BLOOD MODEL; CALCIUM MODEL; CELL FUNCTION; COMPUTER PROGRAM; CONCEPTUAL FRAMEWORK; CYCLIC ADENOSINE MONOPHOSPHATE MODEL; ENDOPLASMIC RETICULUM; GLUCAGON RECEPTOR MODEL; GLUCOSE HOMEOSTASIS; GLYCOGENOLYSIS MODEL; IN VITRO STUDY; INSULIN MODEL; LIVER CELL; LIVER FUNCTION; MATHEMATICAL MODEL; MOLECULAR BIOLOGY; OSCILLATION; PANCREAS MODEL; REVIEW; SYSTEMS BIOLOGY; VALIDATION PROCESS;

EID: 84859388320     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2011.0141     Document Type: Review

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