Increased frequency of the di genotype of the angiotensin-I converting enzyme and association of the II genotype with insulin resistance in polycystic ovary syndrome

European Journal of Endocrinology

Volumn 166, Issue 4, 2012, Pages 695-702

  Koika, Vasiliki ^a   Georgopoulos, Neoklis A ^a   Piouka, Athanasia ^b   Roupas, Nikolaos D ^a   Karela, Anastasia ^a   Armeni, Anastasia K ^a   Katsantoni, Eleni ^a   Panidis, Dimitrios ^b  

^a UNIVERSITY OF PATRAS   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; DIPEPTIDYL CARBOXYPEPTIDASE; HYDROXYPROGESTERONE;

ADULT; ANDROGEN SYNTHESIS; ANOVULATION; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENOTYPE; GENOTYPING TECHNIQUE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HYPERANDROGENISM; INDEL MUTATION; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; OVARY POLYCYSTIC DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL;

ADOLESCENT; ADULT; BLOOD GLUCOSE; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INDEL MUTATION; INSULIN; INSULIN RESISTANCE; PEPTIDYL-DIPEPTIDASE A; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, GENETIC; YOUNG ADULT;

EID: 84859380435     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-11-0894     Document Type: Article

References (44)

1. Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES & Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. Journal of Clinical Endocrinology and Metabolism 2004 89 2745-2749. (doi:10.1210/jc.2003-032046)
2. Diamanti-Kandarakis E, Kouli CR, Bergiele AT, Filandra FA, Tsianateli TC, Spina GG, Zapanti ED & Bartzis MI. A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile. Journal of Clinical Endocrinology and Metabolism 1999 84 4006-4011. (doi:10.1210/jc.84. 11.4006)
3. Asuncion M, Calvo RM, San Millan JL, Sancho J, Avila S & Escobar-Morreale HF. A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. Journal of Clinical Endocrinology and Metabolism 2000 85 2434-2438. (doi:10.1210/jc.85.7.2434)
4. Carmina E & Lobo RA. Polycystic ovary syndrome (PCOS): arguably the most common endocrinopathy is associated with significant morbidity in women. Journal of Clinical Endocrinology and Metabolism 1999 84 1897-1899. (doi:10.1210/jc.84.6.1897)
5. Roterdam. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Human Reproduction 2004 19 41-47. (doi:10.1093/humrep/deh098)
6. Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrine Reviews 1997 18 774-800. (doi:10.1210/er.18.6.774)
7. Escobar-Morreale HF, Botella-Carretero JI, Alvarez-Blasco F, Sancho J & San Millan JL. The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgery. Journal of Clinical Endocrinology and Metabolism 2005 90 6364-6369. (doi:10.1210/jc.2005- 1490)
8. Azziz R & Kashar-Miller MD. Family history as a risk factor for the polycystic ovary syndrome. Journal of Pediatric Endocrinology and Metabolism 2000 13 (Suppl 5) 1303-1306.
9. Kashar-Miller M & Azziz R. Heritability and the risk of developing androgen excess. Journal of Steroid Biochemistry and Molecular Biology 1999 69 261-268. (doi:10.1016/S0960-0760(99)00043-6)
10. Diamanti-Kandarakis E & Piperi C. Genetics of polycystic ovary syndrome: searching for the way out of the labyrinth. Human Reproduction Update 2005 11 631-643. (doi:10.1093/humupd/dmi025)
11. Soldner A, Spahn-Langguth H & Mutschler E. The renin-angiotensin- aldosterone system: focus on its distinct role in arterial hypertension and its various inhibitors as a therapeutic strategy to effectively lower blood pressure. Die Pharmazie 1996 51 783-799. (Pubitemid 26412691)
12. Ferrario CM & Strawn WB. Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease. American Journal of Cardiology 2006 98 121-128. (doi:10.1016/j.amjcard.2006.01.059)
13. Yoshimura Y. The ovarian renin-angiotensin system in reproductive physiology. Frontiers in Neuroendocrinology 1997 18 247-291. (doi:10.1006/frne.1997.0152)
14. van Sande ME, Scharpe SL, Neels HM & Van Camp KO. Distribution of angiotensin converting enzyme in human tissues. Clinica Chimica Acta 1985 147 255-260. (doi:10.1016/0009-8981(85)90207-4)
15. Plendl J, Neumuller C, Vollmar A, Auerbach R & Sinowatz F. Isolation and characterization of endothelial cells from different organs of fetal pigs. Anatomica Embryologica 1996 194 445-456. (doi:10.1007/BF00185992)
16. Acosta TJ, Berisha B, Ozawa T, Sato K, Schams D & Miyamoto A. Evidence for a local endothelin-angiotensin-atrial natriuretic peptide systemin bovine mature follicles in vitro: effects on steroid hormones and prostaglandin secretion. Biology of Reproduction 1999 61 1419-1425. (doi:10.1095/biolreprod61. 6.1419)
17. Nielsen AH, Hagemann A, Svenstrup B, Nielsen J & Poulsen K. Angiotensin II receptor density in bovine ovarian follicles relates to tissue renin and follicular size. Clinical and Experimental Pharmacology & Physiology 1994 21 463-469. (doi:10.1111/j.1440-1681.1994.tb02542.x)
18. Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F &Soubrier F. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. American Journal of Human Genetics 1992 51 197-205.
19. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P &Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. Journal of Clinical Investigation 1990 86 1343-1346. (doi:10.1172/JCI114844)
20. Rigat B, Hubert C, Corvol P & Soubrier F. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Research 1992 20 1433. (doi:10.1093/nar/20.6.1433-a)
21. Rudnicki M & Mayer G. Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease. Pharmacogenomics 2009 10 463-476. (doi:10.2217/14622416.10.3.463)
22. Ferriman D & Gallwey JD. Clinical assessment of body hair growth in women. Journal of Clinical Endocrinology and Metabolism 1961 21 1440-1447. (doi:10.1210/jcem-21-11-1440)
23. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G & Quon MJ. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. Journal of Clinical Endocrinology and Metabolism 2000 85 2402-2410. (doi:10.1210/jc.85.7.2402)
24. Carmina E & Lobo RA. Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome. Fertility and Sterility 2004 82 661-665. (doi:10.1016/j.fertnstert.2004.01.041)
25. Ascaso JF, Pardo S, Real JT, Lorente RI, Priego A & Carmena R. Diagnosing insulin resistance by simple quantitative methods in subjects with normal glucose metabolism. Diabetes Care 2003 26 3320-3325. (doi:10.2337/ diacare.26.12.3320)
26. Zawadski JK & Dunaif A. Diagnostic criteria for polycystic ovary syndrome: toward a rational approach. In Polycystic Ovary Syndrome, pp 377-384. Eds A Dunaif, JR Givens, FP Haseltine &GR Merriam, Boston: Blackwell Scientific, 1992.
27. Azziz R. Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: the Rotterdam criteria are premature. Journal of Clinical Endocrinology and Metabolism 2006 91 781-785. (doi:10.1210/jc.2005-2153)
28. Karabulut A, Turgut S & Turgut G. Angiotensin converting enzyme gene insertion/deletion polymorphism in patients with polycystic ovary syndrome. Gynecological Endocrinology 2010 26 393-398. (doi:10.3109/09513591003632167)
29. Sun J, Fan H, Che Y, Cao Y, Wu X, Sun HX, Liang F, Yi L & Wang Y. Association between ACE gene I/D polymorphisms and hyperandrogenism in women with polycystic ovary syndrome (PCOS) and controls. BMC Medical Genetics 2009 10 64. (doi:10.1186/1471-2350-10-64)
30. Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE & Witchel SF. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertility and Sterility 2009 91 456-488. (doi:10.1016/j.fertnstert.2008.06.035)
31. Kobayashi S, Acosta TJ, Ozawa T, Hayashi K, Berisha B, Ohtani M, Schams D & Miyamoto A. Intraluteal release of angiotensin II and progesterone in vivo during corpora lutea development in the cow: effect of vasoactive peptides. Biology of Reproduction 2002 66 174-179. (doi:10.1095/biolreprod66.1.174)
32. Morris RS, Wonq IL, Hatch IE, Gentschein E, Paulson RJ &Lobo RA. Prorenin is elevated in polycystic ovary syndrome and may reflect hyperandrogenism. Fertility and Sterility 1995 64 1099-1103.
33. Diamanti-Kandarakis E, Economou FN, Livadas S, Tantalaki E, Piperi C, Papavassiliou AG & Panidis D. Hyperreninemia characterizing women with polycystic ovary syndrome improves after metformin therapy. Kidney & Blood Pressure Research 2009 32 24-31. (doi:10.1159/000201791)
34. Do YS, Sherrod A, Lobo RA, Paulson RJ, Shinagawa T, Chen SW, Kjos S & Hsueh WA. Human ovarian theca cells are a source of renin. PNAS 1988 85 1957-1961. (doi:10.1073/pnas.85.6.1957)
35. Palumbo A, Pourmotabbed G, Carcangiu ML, Andrade-Gordon P, Roa L, DeCherney A & Naftolin F. Immunohistochemical localization of renin and angiotensin in the ovary: comparison between normal women and patients with histologically proven polycystic ovarian disease. Fertility and Sterility 1993 60 280-284. (Pubitemid 23228159)
36. Acien P, Quereda F, Matallin P, Villarroya E, Lopez-Fernandez JA, Acien M, Mauri M & Alfayate R. Insulin, androgens, and obesity in women with and without polycystic ovary syndrome: a heterogeneous group of disorders. Fertility and Sterility 1999 72 32-40. (doi:10.1016/S0015-0282(99)00184-3)
37. Livadas S, Boutzios G, Economou F, Alexandraki K, Xyrafis X, Christou M, Zerva A, Karachalios A, Tantalaki E & Diamanti-Kandarakis E. The effect of oral micronized progesterone on hormonal and metabolic parameters in anovulatory patients with polycystic ovary syndrome. Fertility and Sterility 2010 94 242-246. (doi:10.1016/j.fertnstert.2009.02.073)
38. Shiuchi T, Cui TX, Wu L, Nakagami H, Takeda-Matsubara Y, Iwai M & Horiuchi M. ACE inhibitor improves insulin resistance in diabetic mouse via bradykinin and NO. Hypertension 2002 40 329-334. (doi:10.1161/01.HYP.0000028979. 98877.0C)
39. Shiuchi T, Iwai M, Li HS, Wu L, Min LJ, Li JM, Okumura M, Cui TX & Horiuchi M. Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice. Hypertension 2004 43 1003-1010. (doi:10.1161/01.HYP.0000125142.41703.64)
40. Giovannini S, Cesari M, Marzetti E, Leeuwenburgh C, Maggio M &Pahor M. Effects of ACE-inhibition on IGF-1 and IGFBP-3 concentrations in older adults with high cardiovascular risk profile. Journal of Nutrition, Health & Aging 2010 14 457-460. (doi:10.1007/s12603-010-0036-7)
41. Celik O, Yesilada E, Hascalik S, Celik N, Sahin I, Keskin L &Ozerol E. Angiotensin-converting enzyme gene polymorphism and risk of insulin resistance in PCOS. Reproductive BioMedicine Online 2010 20 492-498. (doi:10.1016/j.rbmo.2009.12.014)
42. Ryan AS, Nicklas BJ, Berman DM & Ferrell RE. The insertion/deletion polymorphism of the ACE gene is related to insulin sensitivity in overweight women. Diabetes Care 2001 24 1646-1652. (doi:10.2337/diacare.24.9.1646)
43. Bonnet F, Patel S, Laville M, Balkau B, Favuzzi A, Monti LD, Lalic N & Walker M. Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects. Diabetes Care 2008 31 789-794. (doi:10.2337/dc07-1788)
44. Flanagan DE, Holt RI, Owens PC, Cockington RJ, Moore VM, Robinson JS, Godsland IF & Phillips DI. Gender differences in the insulin-like growth factor axis response to a glucose load. Acta Physiologica 2006 187 371-378. (doi:10.1111/j.1748-1716.2006.01581.x)