Testing strategies for embryo-fetal toxicity of human pharmaceuticals. Animal models vs. in vitro approaches. A workshop report

Regulatory Toxicology and Pharmacology

Volumn 63, Issue 1, 2012, Pages 115-123

  van der Laan, Jan Willem ^a   Chapin, Robert E ^b   Haenen, Bert ^c   Jacobs, Abigail C ^d   Piersma, Aldert ^e,f  

^a MEDICINES EVALUATION BOARD   (Netherlands)

^b PFIZER INC   (United States)

^c 3 D PharmXchange ^*  (Netherlands)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^f UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Developmental and reproductive toxicity; Embryonic stem cell tests; Human pharmaceuticals; International Harmonisation; Rat and rabbit reproductive toxicity; Validation and evaluation; Zebrafish testing

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TESTING ALTERNATIVE; ANIMAL TISSUE; ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; DEVELOPMENTAL TOXICITY; EMBRYO CULTURE; EMBRYONIC STEM CELL; EMBRYOTOXICITY; EXPERIMENTAL RABBIT; EXPERIMENTAL RAT; HEALTH CARE POLICY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RAT; REPRODUCTIVE TOXICITY; SPECIES COMPARISON; TOXICITY TESTING; ZEBRA FISH;

ANIMAL TESTING ALTERNATIVES; ANIMALS; DRUG TOXICITY; EDUCATION; EMBRYO, MAMMALIAN; FETUS; HUMANS; MICE; MODELS, ANIMAL; RABBITS; RATS; RISK ASSESSMENT; TERATOGENS; TOXICITY TESTS; ZEBRAFISH;

ANIMALIA; DANIO RERIO; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 84859373901     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2012.03.009     Document Type: Article

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