Partial biodistribution and pharmacokinetics of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to rhesus macaques

Molecular Pharmaceutics

Volumn 9, Issue 4, 2012, Pages 1011-1016

  Verma, Rahul Kumar ^a   Mukker, Jatinder Kaur ^a   Singh, Ravi Shankar Prasad ^a   Kumar, Kaushlendra ^a   Verma, Priya Ranjan Prasad ^a   Misra, Amit ^a,b  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b BIRLA INSTITUTE OF TECHNOLOGY   (India)

Author keywords

alveolar macrophages; biodegradable microparticles; dry powder inhalation; monkeys; pharmacokinetic parameters; tissue distribution

Indexed keywords

ISONIAZID; RIFABUTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG HALF LIFE; DRUG LIVER LEVEL; DRUG TISSUE LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY; LUNG; LUNG ALVEOLUS MACROPHAGE; MACACA MULATTA; MALE; MAXIMUM PLASMA CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; POWDER INHALER; PRIORITY JOURNAL; SINGLE DRUG DOSE; STEADY STATE;

ANIMALS; ISONIAZID; LUNG; MACACA MULATTA; RIFABUTIN;

EID: 84859357388     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300043f     Document Type: Article

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