In vitro validation of drug-induced phospholipidosis

Journal of Toxicological Sciences

Volumn 37, Issue 2, 2012, Pages 261-267

  Park, Sora ^a   Choi, You Jin ^a   Lee, Byung Hoon ^a  

^a Seoul National University   (South Korea)

Author keywords

Drug induced phospholipidosis; In vitro screening; LipidTox; NBD PE

Indexed keywords

AMIODARONE; CHLOROQUINE; CLOZAPINE; CYCLOSPORIN A; FLUOXETINE; MENADIONE; PARACETAMOL; PROPRANOLOL; SERTRALINE; TAMOXIFEN; TILORONE; VALPROIC ACID;

ARTICLE; CONTROLLED STUDY; DRUG INDUCED DISEASE; DRUG INDUCED PHOSPHOLIPIDOSIS; ELECTRON MICROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; LAMELLAR BODY; LIPIDOSIS; STEATOSIS;

EID: 84859356924     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.37.261     Document Type: Article

References (27)

1. Alakoskela, J.M., Vitovic, P. and Kinnunen, P.K.J. (2009): Screening for the drug-phospholipid interaction: correlation to phospholipidosis. Chem. Med. Chem., 4, 1224-1251.
2. Anderson, N. and Borlak, J. (2006): Drug-induced phospholipidosis. FEBS Letters, 580, 5333-5540.
3. Casartelli, A., Bonato, M., Cristofori, P., Crivellente, F., Dal Negro, G., Masotto, I., Mutinelli, C., Valko, K. and Bontante, V. (2003): A cell-based approach for the early assessment of the phospholipidogenic potential in pharmaceutical research and drug development. Cell Biol. Toxicol., 19, 161-176.
4. El Mouedden, M., Laurent, G., Mingeot-Leclercq, M.P., Taper, H.S., Cumps, J. and Tulkens, P.M. (2000): Apoptosis in renal proxi-mal tubules of rats treated with low doses of aminoglycosides. Antimicrob. Agents Chemother., 44, 665-675.
5. Fujimura, H., Dekura, E., Kurabe, M., Shimazu, N., Koitabashi, M., and Toriumi, W. (2007): Cell-based fluorescence assay for evaluation of new-drugs potential for phospholipidosis in an early stage of drug development. Exp. Toxicol. Pathol., 58, 375-385.
6. Gonzalez-Rhoti, R.J., Zander, D.S. and Ros, P.R. (1995): Fluoxetine hydrochloride (Prozac)-induced pulmonary disease. Chest, 107, 1763-1765.
7. Honegger, U.E., Quack, G. and Wiesmann, U.N. (1993): Evidence for lysosomotropism of memantine in cultured human Cells: Cellular kinetics and effects of memantine on phospholipid content and composition, membrane fluidity and beta-adrenergic transmission. Biochem. Pharmacol., 73, 202-208.
8. Jaeschke, H., Gores, G.J., Cederbaum, A.I., Hinson, J.A., Pessayre, D. and Lemaster, J.J. (2002): Mechanisms of hepatotoxicity. Toxicol. Sci., 65, 166-176.
9. Kasahara, T., Tomita, K., Murano, H., Harada, T., Tsubakimoto, K., Ogihara, T., Ohnishi, S. and Kakinuma, C. (2006): Establishment of an in vitro high-throughput screening assay for detecting phospholipidosis-inducing potential. Toxicol. Sci., 90, 133-141.
10. Leeson, G.A., Biedenbach, S.A., Chan, K.Y., Gibson, J.P. and Wright, G.J. (1976): Decrease in the activity of the drug-metabolizing enzymes of rat liver following the administration of tilorone hydrochloride. Drug Metab. Dispos., 4, 232-238.
11. Lullmann, H., Lüllmann-Rauch, R. and Wassermann, O. (1978): Lipidosis induced by amphiphilic cationic drugs. Biochem. Pharmacol., 27, 1103-1108.
12. Miyamoto, S., Matsumoto, A., Mori, I. and Horinouchi, A. (2009): Relationship between in vitro phospholipidosis assay using HepG2 cells and 2-week toxicity studies in rats. Toxicol. Mech. Methods, 19, 477-485.
13. Monteith, D.K., Morgan, R.E. and Halstead, B. (2006): In vitro assays and biomarkers for drug-induced phospholipidosis. Expert Opin. Drug Metab. Toxicol., 2, 687-696.
14. Morelli, J.K., Buehrle, M., Pognan, F., Barone, L.R., Fieles, W. and Ciaccio, P.J. (2006): Validation of an in vitro screen for phospholipidosis using a high-content biology platform. Cell biol. Toxicol., 22, 15-27.
15. Mouedden, M.E., Laurent, G., Mingeot-Leclercq, M.P., Taper, H.S., Cumps, J. and Tulkens, P.M. (2000): Apoptosis in renal proximal tubules of rats treated with low doses of aminoglycosides. Antimicrob. Agents Chemother., 44, 665-675.
16. Nioi, P., Perry, B.K., Wang, E.J., Gu, Y.Z. and Snyder, R.D. (2007): In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol. Sci., 99, 162-173.
17. Piccotti, J.R., Lagattuta, M.S., Knight, S.A., Gonzales, A.J. and Bleavins, M.R. (2005): Induction of apoptosis by cationic amphiphilic drugs amiodarone and imipramine. Drug Chem. Toxicol., 28, 117-133.
18. Reasor, M.J. and Kacew, S. (2001): Drug-induced phospholipidosis: Are there functional consequences? Exp. Bio. Med., 226, 825-830.
19. Reasor, M.J., Hastings, K.L. and Ulrich, R.G. (2006): Drug-induced phospholipidosis:issues and future directions. Expert Opin. Drug Saf., 5, 567-583.
20. Sawada, H., Takami, K. and Asahi, S. (2005): A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol. Sci., 83, 282-292.
21. Smith, E.L. and Schuchman E.H. (2008): The unexpected role of acid sphingomyelinase in cell death and the pathologiology of common disease. FASEB J, 22, 3419-3431.
22. Tang, W., Borel, A.G., Fujimiya, T. and Abbott, F.S. (1995): Fluorinated analogues as mechanistic probes in valproic acid hepatotoxicity: hepatic microvesicular steatosis and glutathione status. Chem. Res. Toxicol., 8, 671-682.
23. Tengstrand, E.A., Miwa, G.T. and Hsieh, F.Y. (2010): Bis(monoacylglycerol)phosphate as a non-invasive biomarker to monitor the onset and time-course of phospholipidosis with drug-induced toxicities. Expert Opin. Drug Metab. Toxicol., 6, 555-570.
24. Waters, E., Wang, J.H., Redmond, H.P., Wu, Q.D., Kay, E. and Bouchier-Hayes, D. (2001): Role of taurine in preventing acetaminophen-induced hepatic injury in the rat. Am. J. Physiol. Gastrointest. Liver Physiol., 280, G1274-1279.
25. Weiss, J.N., Weinberg, R.S. and Regelson, W. (1980): Keratopathy after oral administration of tilorone hydrochloride. Am. J. Ophthalmol., 89, 46-53.
26. www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/maceuticalScienceandClinicalPharmacology/UCM207737.pdf: FDA webpage (last visited in Oct 17, 2011)
27. Yamamoto, A., Adachi, S., Ishikawa, K., Yokomura, T., Kitani, T., Nasu, T., Imoto, T. and Nishikawa, M. (1971): Studies on druginduced lipidosis: 3. Lipid composition of the liver and some other tissues in clinical cases of "Niemann-Pick-like syndrome" induced by 4,4'-diethylaminoethoxyhexestrol. J. Biochem., 70, 775-778.