Estrogen receptor-α mediates diethylstilbestrol-induced feminization of the seminal vesicle in male mice

Environmental Health Perspectives

Volumn 120, Issue 4, 2012, Pages 560-565

  Walker, Vickie R ^a   Jefferson, Wendy N ^a   Couse, John F ^a,b   Korach, Kenneth S ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b Taconic Inc   (United States)

Author keywords

Development; Endocrine disruptor; Reproductive tract

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; LACTOFERRIN; SEMINAL VESICLE SECRETORY PROTEIN; SEMINAL VESICLE SECRETORY PROTEIN IV; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEMINIZATION; KNOCKOUT MOUSE; MALE; MOUSE; NEWBORN; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMINAL VESICLE; WESTERN BLOTTING;

ANDROGENS; ANIMALS; BLOTTING, WESTERN; CASTRATION; DIETHYLSTILBESTROL; DIHYDROTESTOSTERONE; DISEASE MODELS, ANIMAL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMINIZATION; GENE EXPRESSION; LACTOFERRIN; MALE; MICE; MICE, KNOCKOUT; RADIOIMMUNOASSAY; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ANDROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEMINAL VESICLE SECRETORY PROTEINS; SEMINAL VESICLES;

MUS;

EID: 84859345916     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1103678     Document Type: Article

References (41)

1. Beckman WC Jr, Newbold RR, Teng CT, McLachlan JA. 1994. Molecular feminization of mouse seminal vesicle by prenatal exposure to diethylstilbestrol: altered expression of messenger RNA. J Urol 151:1370-1378.
2. Bibbo M, Gill WB, Azizi F, Blough R, Fang VS, Rosenfield RL, et al. 1977. Follow-up study of male and female offspring of DES-exposed mothers. Obstet Gynecol 49:1-8.
3. Conley GR, Sant GR, Ucci AA, Mitcheson HD. 1983. Seminoma and epididymal cysts in a young man with known diethylstilbestrol exposure in utero. JAMA 249:1325-1326.
4. Cooke PS, Young P, Hess RA, Cunha GR. 1991. Estrogen receptor expression in developing epididymis, efferent ductules, and other male reproductive organs. Endocrinology 128:2874-2879.
5. Couse JF, Dixon D, Yates M, Moore AB, Ma L, Maas R, et al. 2001. Estrogen receptor-α knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract. Dev Biol 238:224-238.
6. Couse JF, Korach KS. 1999. Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev 20:358-417.
7. Couse JF, Korach KS. 2004. Estrogen receptor-α mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract. Toxicology 205:55-63.
8. Couse JF, Yates MM, Walker VR, Korach KS. 2003. Characterization of the hypothalamic-pituitary-gonadalaxis in estrogen receptor (ER) null mice reveals hypergonadism and endocrine sex reversal in females lacking ERα but not ERβ. Mol Endocrinol 17:1039-1053.
9. Gill WB, Schumacher GF, Bibbo M, Straus FH II, Schoenberg HW. 1979. Association of diethylstilbestrol exposure in utero with cryptorchidism, testicular hypoplasia and semen abnormalities. J Urol 122:36-39.
10. Herbst AL, Ulfelder H, Poskanzer DC. 1971. Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med 284(15):878-881.
11. Institute of Laboratory Animal Research. 2011. Guide for the Care and Use of Laboratory Animals. 8th ed. Washington, DC:National Academy Press.
12. Jefferson WN, Teng C, Newbold RR. 1996. Methodologies for isolating estrogen-responsive proteins as markers of environmental toxicants. Toxciol Mech Methods 6:183-192.
13. Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, et al. 1998. Generation and reproductive phenotypes of mice lacking estrogen receptor β. Proc Natl Acad Sci USA 95:15677-15682.
14. Li S, Washburn KA, Moore R, Uno T, Teng C, Newbold RR, et al. 1997. Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus. Cancer Res 57:4356-4359.
15. Lim P, Allan CM, Notini AJ, Axell AM, Spaliviero J, Jimenez M, et al. 2008. Oestradiol-induced spermatogenesis requires a functional androgen receptor. Reprod Fertil Dev 20:861-870.
16. Lindzey J, Wetsel WC, Couse JF, Stoker T, Cooper R, Korach KS. 1998. Effects of castration and chronic steroid treatments on hypothalamic gonadotropin-releasing hormone content and pituitary gonadotropins in male wild-type and estrogen receptor-α knockout mice. Endocrinology 139:4092-4101.
17. Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O. 1993. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci USA 90:11162-11166.
18. Lung B, Cunha GR. 1981. Development of seminal vesicles and coagulating glands in neonatal mice. I. The morphogenetic effects of various hormonal conditions. Anat Rec 199:73-88.
19. Marselos M, Tomatis L. 1992. Diethylstilboestrol. I. Pharmacology, toxicology and carcinogenicity in humans. Eur J Cancer 28A:1182-1189.
20. Marselos M, Tomatis L. 1993. Diethylstilboestrol. II. Pharmacology, toxicology and carcinogenicity in experimental animals. Eur J Cancer 29A:149-155.
21. McLachlan JA. 1977. Prenatal exposure to diethylstilbestrol in mice: toxicological studies. J Toxicol Environ Health 2:527-537.
22. McLachlan JA, Newbold RR, Bullock B. 1975. Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol. Science 190:991-992.
23. McLachlan JA, Newbold RR, Bullock BC. 1980. Long-term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol. Cancer Res 40:3988-3999.
24. Nelson KG, Sakai Y, Eitzman B, Steed T, McLachlan J. 1994. Exposure to diethylstilbestrol during a critical developmental period of the mouse reproductive tract leads to persistent induction of two estrogen-regulated genes. Cell Growth Differ 5:595-606.
25. Newbold RR. 2004. Lessons learned from perinatal exposure to diethylstilbestrol. Toxicol Appl Pharmacol 199:142-150.
26. Newbold RR, Bullock BC, McLachlan JA. 1990. Uterine adenocarcinoma in mice following developmental treatment with estrogens: a model for hormonal carcinogenesis. Cancer Res 50:7677-7681.
27. Newbold RR, Hanson RB, Jefferson WN, Bullock BC, Haseman J, McLachlan JA. 2000. Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis 21:1355-1363.
28. Newbold RR, Jefferson WN, Grissom SF, Padilla-Banks E, Snyder RJ, Lobenhofer EK. 2007. Developmental exposure to diethylstilbestrol alters uterine gene expression that may be associated with uterine neoplasia later in life. Mol Carcinog 46:783-796.
29. Newbold RR, Pentecost BT, Yamashita S, Lum K, Miller JV, Nelson P, et al. 1989. Female gene expression in the seminal vesicle of mice after prenatal exposure to diethylstilbestrol. Endocrinology 124:2568-2576.
30. Niculescu AM. 1985. Effects of in utero exposure to DES on male progeny. J Obstet Gynecol Neonatal Nurs 14:468-470.
31. Pentecost BT, Newbold RR, Teng CT, McLachlan JA. 1988. Prenatal exposure of male mice to diethylstilbestrol alter the expression of the lactotransferrin gene in seminal vesicles. Mol Endocrinol 2:1243-1248.
32. Pfaffl MW. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29(9):e45.
33. Prins GS. 1992. Neonatal estrogen exposure induces lobe-specific alterations in adult rat prostate androgen receptor expression. Endocrinology 130:2401-2412.
34. Prins GS, Birch L, Couse JF, Choi I, Katzenellenbogen B, Korach KS. 2001. Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor α: studies with αERKO and βERKO mice. Cancer Res 61:6089-6097.
35. Risbridger GP, Taylor RA. 2006. Physiology of the male accessory sex structures: the prostate gland, seminal vesicles, and bulbourethral glands. In: Knobil and Neill's Physiology of Reproduction (Neill JD, ed). 3rd ed. St Louis:Academic Press, 1149-1172.
36. Shima H, Tsuji M, Young P, Cunha GR. 1990. Postnatal growth of mouse seminal vesicle is dependent on 5α-dihydrotestosterone. Endocrinology 127:3222-3233.
37. Turner T, Edery M, Mills KT, Bern HA. 1989. Influence of neonatal diethylstilbestrol treatment on androgen and estrogen receptor levels in the mouse anterior prostate, ventral prostate and seminal vesicle. J Steroid Biochem 32:559-564.
38. Wilcox AJ, Baird DD, Weinberg CR, Hornsby PP, Herbst AL. 1995. Fertility in men exposed prenatally to diethylstilbestrol. N Engl J Med 332:1411-1416.
39. Williams K, Fisher JS, Turner KJ, McKinnell C, Saunders PT, Sharpe RM. 2001. Relationship between expression of sex steroid receptors and structure of the seminal vesicles after neonatal treatment of rats with potent or weak estrogens. Environ Health Perspect 109:1227-1235.
40. Williams K, Saunders PT, Atanassova N, Fisher JS, Turner KJ, Millar MR, et al. 2000. Induction of progesterone receptor immunoexpression in stromal tissue throughout the male reproductive tract after neonatal oestrogen treatment of rats. Mol Cell Endocrinol 164:117-131.
41. Yamashita S. 2004. Ontogenic expression of estrogen receptor coactivators in the reproductive tract of female mice neonatally exposed to diethylstilbestrol. Reprod Toxicol 18:275-284.