Bisphosphonate remains highly localized after elution from porous implants

Clinical Orthopaedics and Related Research

Volumn 469, Issue 2, 2011, Pages 514-522

  McKenzie, Kimberly ^a   Dennis Bobyn, J ^a,b   Roberts, Jacintha ^a   Karabasz, Dorota ^a   Tanzer, Michael ^a  

^a MONTREAL GENERAL HOSPITAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; HYDROXYAPATITE; TANTALUM; ZOLEDRONIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AUTORADIOGRAPHY; BONE MARROW; CONFERENCE PAPER; CONTROLLED STUDY; CORTICAL BONE; DOG; DRUG BONE LEVEL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EXPOSURE; ELUTION; FEMUR; HISTOPATHOLOGY; IMPLANT; ISOTOPE LABELING; LIQUID SCINTILLATION COUNTING; MATERIAL COATING; NONHUMAN; POROSITY; PRIORITY JOURNAL; SKELETON; SPECTROPHOTOMETRY; TREATMENT DURATION;

EID: 78951470840     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1007/s11999-010-1527-x     Document Type: Conference Paper

References (28)

1. MR Allen K Iwata R Phipps DB Burr 2006 Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate Bone. 39 872 879 1:CAS:528:DC%2BD28XpsVOhurY%3D 10.1016/j.bone.2006.04.028 16765660
2. N Amanat M McDonald C Godfrey L Bilston D Little 2007 Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair J Bone Miner Res. 22 867 876 1:CAS:528:DC%2BD2sXpt12jtr0%3D 10.1359/jbmr.070318 17371160
3. J Åstrand P Aspenberg 2004 Topical, single dose bisphosphonate treatment reduced bone resorption in a rat model for prosthetic loosening J Orthop Res. 22 244 249 10.1016/j.orthres.2003.08.008 15013081
4. DM Black PD Delmas R Eastell IR Reid S Boonen JA Cauley F Cosman P Lakatos PC Leung Z Man C Mautalen P Mesenbrink H Hu J Caminis K Tong T Rosario-Jansen J Krasnow TF Hue D Sellmeyer EF Eriksen SR Cummings 2007 Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis N Engl J Med. 356 1809 1822 1:CAS:528:DC%2BD2sXltVSktLc%3D 10.1056/NEJMoa067312 17476007
5. JD Bobyn K McKenzie D Karabasz JJ Krygier M Tanzer 2009 Locally delivered bisphosphonate for enhancement of bone formation and implant fixation J Bone Joint Surg Am. 91 23 31 10.2106/JBJS.I.00518 19884409
6. MT Drake BT Clarke S Khosla 2008 Bisphosphonates: mechanisms of action and role in clinical Practice Mayo Clin Proc. 83 1032 1045 1:CAS:528: DC%2BD1cXhtFensLrJ 10.4065/83.9.1032 18775204
7. Y Gao S Zou X Liu C Bao J Hu 2009 The effect of surface immobilized bisphosphonates on the fixation of hydroxyapatite-coated titanium implants in ovariectomized rats Biomaterials. 30 1790 1796 1:CAS:528:DC%2BD1MXht1ejsLY%3D 10.1016/j.biomaterials.2008.12.025 19135249
8. DS Garbuz Y Hu WY Kim K Duan BA Masri TR Oxland H Burt R Wang CP Duncan 2008 Enhanced gap filling and osteoconduction associated with alendronate-calcium phosphate-coated porous tantalum J Bone Joint Surg Am. 90 1090 1100 10.2106/JBJS.G.00415 18451402
9. SK Goh KY Yang JS Koh MK Wong SY Chua DT Chua TS Howe 2007 Subtrochanteric insufficiency fractures in patients on alendronate therapy: a caution J Bone Joint Surg Br. 89 349 353 10.1302/0301-620X.89B3.18146 17356148
10. M Hilding P Aspenberg 2007 Local peroperative treatment with a bisphosphonate improves the fixation of total knee prostheses. A randomized, double-blind radiostereometric study of 50 patients Acta Orthop 78 795 799 10.1080/17453670710014572 18236186
11. M Hilding L Ryd S Toksvig-Larsen P Aspenberg 2000 Clodronate prevents prosthetic migration: a randomized radiostereometric study of 50 total knee patients Acta Orthop Scand. 71 553 557 1:STN:280:DC%2BD3M%2Fos1Gmsw%3D%3D 10.1080/000164700317362163 11145380
12. T Jakobsen J Baas S Kold JE Bechtold B Elmengaard K Soballe 2009 Local bisphosphonate treatment increases fixation of hydroxyapatite-coated implants inserted with bone compaction J Orthop Res. 27 189 194 1:CAS:528: DC%2BD1MXhvVCit78%3D 10.1002/jor.20745 18752278
13. EB Kwek JS Koh TS Howe 2008 More on atypical fractures of the femoral diaphysis [Letter] N Engl J Med. 359 316 318 1:CAS:528:DC%2BD1cXoslGitLw%3D 10.1056/NEJMc080861 18635442
14. F Legay S Gauron F Deckert G Gosset U Pfaar C Ravera H Wiegand H Schran 2002 Development and validation of a highly sensitive RIA for zoledronic acid, a new potent heterocyclic bisphosphonate in human serum, plasma and urine J Pharm Biomed Anal. 30 897 911 1:CAS:528:DC%2BD38Xot1equ78%3D 10.1016/S0731-7085(02) 00218-2 12408879
15. BA Lenart DG Lorich JM Lane 2008 Atypicial fractures of the femoral diaphysis in postmenopausal women taking alendronate N Engl J Med. 358 1304 1306 1:CAS:528:DC%2BD1cXjvVarsb8%3D 10.1056/NEJMc0707493 18354114
16. KW Lyles CS Colón-Emeric JS Magaziner JD Adachi CF Pieper C Mautalen L Hyldstrup C Recknor L Nordsletten KA Moore C Lavecchia J Zhang P Mesenbrink PK Hodgson K Abrams JJ Orloff Z Horowitz EF Eriksen S Boonen 2007 Zoledronic acid and clinical fractures and mortality after hip fracture N Engl J Med. 357 1799 1809 1:CAS:528:DC%2BD2sXht1Kit7nN 10.1056/NEJMoa074941 17878149
17. T Mashiba T Hirano CH Turner MR Forwood CC Johnston DB Burr 2000 Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib J Bone Miner Res. 15 613 620 1:CAS:528:DC%2BD3cXisFWmtr4%3D 10.1359/jbmr.2000.15.4.613 10780852
18. T Mashiba CH Turner T Hirano MR Forwood CC Johnston DB Burr 2001 Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles Bone. 28 524 531 1:CAS:528:DC%2BD3MXjtlChsLk%3D 10.1016/S8756-3282(01)00414-8 11344052
19. PD Papapetrou 2009 Bisphosphonate-associated adverse events Hormones. 8 96 110 19570737
20. B Peter O Gauthier S Laïb B Bujoli J Guicheux P Janvier GH van Lenthe R Müller PY Zambelli JM Bouler DP Pioletti 2006 Local delivery of bisphosphonate from coated orthopedic implants increases implants mechanical stability in osteoporotic rats J Biomed Mat Res Part A. 76 133 143 10.1002/jbm.a.30456
21. B Peter DP Pioletti S Laïb B Bujoli P Pilet P Janvier J Guicheux PY Zambelli JM Bouler O Gauthier 2005 Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration Bone. 36 52 60 1:CAS:528:DC%2BD2MXkvVeqsA%3D%3D 10.1016/j.bone.2004.10.004 15664002
22. RG Russell Z Xia JE Dunford U Oppermann A Kwaasi PA Hulley KL Kavanagh JT Triffitt MW Lundy RJ Phipps BL Barnett FP Coxon MJ Rogers NB Watts FH Ebetino 2007 Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy Ann NY Acad Sci. 1117 209 257 1:CAS:528:DC%2BD1cXhtVGmurY%3D 10.1196/annals.1402.089 18056045
23. Saleh KJ, Mulhall KJ, Hofmann AA, Bolognesi MP, Laskin RS. Primary total knee arthroplasty outcomes. In: Barrack RL, Booth RE Jr, Lonner JH, McCarthy JC, Mont MA, Rubash HE, eds. Orthopaedic Knowledge Update 3-Hip and Knee Reconstruction. Rosemont, IL: Amer Acad Orthop Surg; 2006:93-110.
24. Sporer S, Paprosky WG, Berry DJ. Hip revision. In: Barrack RL, Booth RE Jr, Lonner JH, McCarthy JC, Mont MA, Rubash HE, eds. Orthopaedic Knowledge Update 3-Hip and Knee Reconstruction. Rosemont, IL: Amer Acad Orthop Surg; 2006:457-474.
25. VA Stadelmann O Gauthier A Terrier JM Bouler DP Pioletti 2008 Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model: a pilot study Eur Cell Mater. 16 10 16 1:CAS:528:DC%2BD1cXht1Kgs7jM 18671203
26. SJ Suratwala SK Cho JJ van Raalte SH Park SW Seo SS Chang TR Gardner FY Lee 2008 Enhancement of periprosthetic bone qwuality with topical hydroxyapatite-bisphosphonate composite J Bone Joint Surg Am. 90 2189 2196 10.2106/JBJS.G.00409 18829917
27. M Tanzer D Karabasz JJ Krygier R Cohen JD Bobyn 2005 Bone augmentation around and within porous implants by local bisphosphonate elution Clin Orthop Relat Res. 441 30 39 10.1097/01.blo.0000194728.62996.2d 16330982
28. A Yaffe I Binderman E Breuer T Pinto G Golomb 1999 Disposition of alendronate following local delivery in a rat jaw J Periodontol. 70 893 895 1:CAS:528:DyaK1MXlvFSms7s%3D 10.1902/jop.1999.70.8.893 10476897