Influence of protein histidine phosphatase overexpression and down-regulation on human umbilical-vein endothelial cell viability

Cell Biology International

Volumn 36, Issue 3, 2012, Pages 245-249

  Seeger, Anna ^a   Rose, Karsten ^a   Ma, Nien Tze ^a   Kremmer, Elisabeth ^b   Klumpp, Susanne ^a   Krieglstein, Josef ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Histidine phosphorylation; Human umbilical vein endothelial cells (HUVEC); Protein histidine phosphatase (PHP)

Indexed keywords

CELL PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PLASMID VECTOR; PROTEIN HISTIDINE PHOSPHATASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CELL SURVIVAL; DOWN-REGULATION; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; PHOSPHORIC MONOESTER HYDROLASES; RATS; RNA, SMALL INTERFERING;

MAMMALIA;

EID: 84859230208     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1042/CBI20100572     Document Type: Article

References (17)

1. Baeumer N, Maeurer A, Krieglstein J, Klumpp S. Expression of protein histidine phosphatase in Escherichia coli, purification and determination of enzyme activity. Methods Mol Biol 2006;365:247-60.
2. Ek P, Pettersson G, Ek B, Gong F, Li J, Zetterqvist O. Identification and characterization of a mammalian 14-kDa phosphohistidine phosphatase. Eur J Biochem 2002;269:5016-23.
3. Gong W, Li Y, Cui G, Hu J, Fang H, Jin C et al. Solution structure and catalytic mechanism of human protein histidine phosphatase 1. Biochem J 2009;418:337-44.
4. Hartree EF. Determination of protein: a modification of the Lowry method that gives a linear photometric response. Anal Biochem 1972;48:422-7.
5. Hermesmeier J, Klumpp S. Histidine phosphatase activity in vertebrates. Arch Pharm Pharm Med Chem 1999;332:34.
6. Klumpp S, Krieglstein J. Reversible phosphorylation of histidine residues in proteins from vertebrates. Sci Signal 2009;2:13.
7. Klumpp S, Hermesmeier J, Selke D, Baumeister R, Kellner R, Krieglstein J. Protein histidine phosphatase: a novel enzyme with potency for neuronal signaling. J Cereb Blood Flow Metab 2002;22:1420-24.
8. Klumpp S, Bechmann G, Maeurer A, Selke D, Krieglstein J. ATP-citrate lyase as a substrate of protein histidine phosphatase in vertebrates. Biochem Biophys Res Commun 2003;306:110-15.
9. Klumpp S, Faber D, Fischer D, Litterscheid S, Krieglstein J. Role of protein histidine phosphatase for viability of neuronal cells. Brain Res 2008;1264:7-12.
10. Krieglstein J, Hufnagel B, Dworak M, Schwarz S, Kewitz T, Reinbold M et al. Influence of various fatty acids on the activity of protein phosphatase type 2C and apoptosis of endothelial cells and macrophages. Eur J Pharm Sci 2008a;35:397-403.
11. Krieglstein J, Lehmann M, Maeurer A, Gudermann T, Pinkenburg O, Wieland T et al. Reduced viability of neuronal cells after overexpression of protein histidine phosphatase. Neurochem Int 2008b;53:132-6.
12. Krieglstein J, Kewitz T, Kirchhefer U, Hofnagel O, Weißen-Plenz G, Reinbold M et al. Damage of guinea pig heart and arteries by a trioleate-enriched diet and of cultured cardiomyocytes by oleic acid. PLoS ONE 2010;5:e9561.
13. Ma R, Kanders E, Beckmann Sundh U, Geng M, Ek P, Zetterqvist O et al. Mutational study of human phosphohistidine phosphatase: effect on enzymatic activity. Biochem Biophys Res Commun 2005;337:887-91.
14. Maeurer A, Wieland T, Meissl F, Niroomand F, Mehringer R, Krieglstein J et al. The ß-subunit of G proteins is a substrate of protein histidine phosphatase. Biochem Biophys Res Commun 2005;334:1115-20.
15. + channel KCa3.1. Proc Natl Acad Sci USA 2008;105:14442-46.
16. Xu A, Hao J, Zhang Z, Tian T, Jiang S, Hao J et al. 14-kDa phosphohistidine phosphatase and its role in human lung cancer cell migration and invasion. Lung Cancer 2010;67:48-56.
17. Zhang XQ, Sundh UB, Jansson L, Zetterqvist O, Ek P. Immunohistochemical localization of phosphohistidine phosphatase PHPT1 in mouse and human tissues. Ups J Med Sci 2009;114:65-72.