Infusion of BDNF into the nucleus accumbens of aged rats improves cognition and structural synaptic plasticity through PI3K-ILK-Akt signaling

Behavioural Brain Research

Volumn 231, Issue 1, 2012, Pages 146-153

  Li, Min ^a   Dai, Fu rong ^a   Du, Xiao ping ^a   Yang, Qi dong ^a   Zhang, Xiuwu ^b   Chen, Yuxiang ^c  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Akt phosphorylation; BDNF; Cognition; ILK; Nucleus accumbens; Synaptic plasticity; Trk receptors

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; INTEGRIN LINKED KINASE; NEUROTROPHIN RECEPTOR P75; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE A; SERINE;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; COGNITIVE DEFECT; CONTROLLED STUDY; DENDRITIC SPINE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; GOLGI STAIN; MAZE TEST; NERVE CELL CULTURE; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITION; DENDRITES; NEURONAL PLASTICITY; NEURONS; NUCLEUS ACCUMBENS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TRKA; RECEPTOR, TRKB; SIGNAL TRANSDUCTION; SYNAPSES;

EID: 84859178966     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.03.010     Document Type: Article

References (37)

1. Grady C.L., Furey M.L., Pietrini P., Horwitz B., Rapoport S.I. Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease. Brain 2001, 124:739-756.
2. Takahashi E., Niimi K., Itakura C. Role of CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory. Behav Brain Res 2011, 218:353-356.
3. Lajtha A., Sershen H. Heterogeneity of reward mechanisms. Neurochem Res 2001, 35:851-867.
4. de Jong L.W., van der Hiele K., Veer I.M., Houwing J.J., Westendorp R.J.L., Bollen E.L.E.M., et al. Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study. Brain 2008, 131:3277-3285.
5. Fumagalli F., Racagni G., Riva M.A. The expanding role of BDNF: a therapeutic target for Alzheimer's disease. Pharmacogenomics J 2006, 6:8-15.
6. Arancibia S., Silhol M., Moulière F., Meffre J., Höllinger I., Maurice T., et al. Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats. Neurobiol Dis 2008, 31:316-326.
7. Laske C., Stransky E., Leyhe T., Eschweiler G.W., Maetzler W., Wittorf A., et al. DNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls. J Psychiatr Res 2007, 41:387-394.
8. Nagahara A.H., Merrill D.A., Coppola G., Tsukada S., Schroeder B.E., Shaked G.M., et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med 2009, 15:331-337.
9. Huang E.J., Reichardt L.F. Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem 2003, 72:609-642.
10. Weinreb O., Amit T., Bar-Am O., Youdim M.B. Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy. Ann N Y Acad Sci 2007, 1122:155-168.
11. Siegel G.J., Chauhan N.B. Neurotrophic factors in Alzheimer's and Parkinson's disease brain. Brain Res. Brain Res Rev 2000, 33:199-227.
12. Downward J. Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol 1998, 10:262-267.
13. Zhang X., Mi J., Wetsel W.C., Davidson C., Xiong X., Chen Q., et al. PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity. Biochem Biophys Res Commun 2006, 340:1144-1150.
14. Dedhar S. Cell-substrate interactions and signaling through ILK. Curr Opin Cell Biol 2000, 12:250-256.
15. Mills J., Digicaylioglu M., Legg A.T., Young C.E., Young S.S., Barr A.M., et al. Role of integrin-linked kinase in nerve growth factor-stimulated neurite outgrowth. J Neurosci 2003, 23:1638-1648.
16. Ishii T., Furuoka H., Muroi Y., Nishimura M. Inactivation of integrin-linked kinase induces aberrant tau phosphorylation via sustained activation of glycogen synthase kinase 3beta in N1E-115 neuroblastoma cells. J Biol Chem 2003, 278:26970-26975.
17. Gary D.S., Milhavet O., Camandola S., Mattson M.P. Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neurons. J Neurochem 2003, 84:878-890.
18. Xu J., Rong S., Xie B., Sun Z., Deng Q., Wu H., et al. Memory impairment in cognitively impaired aged rats associated with decreased hippocampal CREB phosphorylation: reversal by procyanidins extracted from the lotus seedpod. J Gerontol A Biol Sci Med Sci 2010, 65:933-940.
19. Zhu X., Li T., Peng S., Ma X., Chen X., Zhang X. Maternal deprivation-caused behavioral abnormalities in adult rats relate to a non-methylation-regulated D2 receptor levels in the nucleus accumbens. Behav Brain Res 2010, 209:281-288.
20. Chen Q., Xiong X., Lee T.H., Liu Y., Sun Q.A., Wetsel W., et al. Adeno-associated virus-mediated ILK gene silencing in the rat NAc core. J Neurosci Methods 2008, 173:208-214.
21. Zhang X., Lee T.H., Davidson C., Lazarus C., Wetsel W.C., Ellinwood E.H. Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors. Neuropsychopharmacology 2007, 32:377-387.
22. Ross G.M., Shamovsky I.L., Lawrance G., Solc M., Dostaler S.M., Weaver D.F., et al. Reciprocal modulation of TrkA and p75NTR affinity states is mediated by direct receptor interactions. Eur J Neurosci 1998, 10:890-898.
23. Woronowicz A., Amith S.R., Davis V.W., Jayanth P., De Vusser K., Laroy W., et al. Trypanosome trans-sialidase mediates neuroprotection against oxidative stress, serum/glucose deprivation, and hypoxia-induced neurite retraction in Trk-expressing PC12 cells. Glycobiology 2007, 17:725-734.
24. Hempstead B.L., Rabin S.J., Kaplan L., Reid S., Parada L.F., aKaplan D.R. Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation. Neuron 1992, 9:883-896.
25. MacDonald J.I.S., Kubu C.J., Meakin S.O. Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth. J Cell Biol 2004, 164:851-862.
26. Baskey J.C., Kalisch B.E., Davis W.L., Meakin S.O., aRylett R.J. PC12nnr5 cells expressing TrkA receptors undergo morphological but not cholinergic phenotypic differentiation in response to nerve growth factor. J Neurochem 2002, 80:501-511.
27. Woronowicz A., De Vusser K., Laroy W., Contreras R., Meakin S.O., Ross G.M., Szewczuk M.R. Trypanosome trans-sialidase targets TrkA tyrosine kinase receptor and induces receptor internalization and activation. Glycobiology 2004, 14:987-998.
28. Meakin S.O., MacDonald J.I. A novel juxtamembrane deletion in rat TrkA blocks differentiative but not mitogenic cell signaling in response to nerve growth factor. J Neurochem 1998, 71:1875-1888.
29. Lu B., Chow A. Neurotrophins and hippocampal synaptic transmission and plasticity. J Neurosci Res 1999, 58:76-87.
30. Rankin S.L., Guy C.S., Mearow K.M. TrkA NGF receptor plays a role in the modulation of p75NTR expression. Neurosci Lett 2005, 383:305-310.
31. Larsson E., Lindvall O., Kokaia Z. Stereological assessment of vulnerability of immunocytochemically identified striatal and hippocampal neurons after global cerebral ischemia in rats. Brain Res 2001, 913:117-132.
32. Miller M.W., Pitts F.A. Neurotrophin receptors in the somatosensory cortex of the mature rat: co-localization of p75, trk, isoforms and c-neu. Brain Res 2000, 852:355-366.
33. Brami-Cherrier K., Valjent E., Garcia M., Pages C., Hipskind R.A., Caboche J. Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: a new route to cAMP response element-binding protein phosphorylation. J Neurosci 2002, 22:8911-8921.
34. Zhu D., Lipsky R.H., Marini A.M. Co-activation of the phosphatidylinositol-3-kinase/Akt signaling pathway by N-methyl-d-aspartate and TrkB receptors in cerebellar granule cell neurons. Amino Acids 2002, 23:11-17.
35. Savonenko A.V., Melnikova T., Hiatt S., Tong S., Li T., Worley P.F., et al. Alzheimer's therapeutics: translation of preclinical science to clinical drug development. Neuropsychopharmacology 2011, 36:1-17.
36. Ferrarini L., Palm W.M., Olofsen H., van Buchem M.A., Reiber J.H., Admiraal-Behloul F. Shape differences of the brain ventricles in Alzheimer's disease. NeuroImage 2006, 32:1060-1069.
37. Almeida O.P., Burton E.J., McKeith I., Gholkar A., Burn D., O'Brien J.T. MRI study of caudate nucleus volume in Parkinson's disease with and without dementia with Lewy bodies and Alzheimer's disease. Dement Geriatr Cogn Disord 2003, 16:57-63.