Is there an association between angiotensin converting enzyme (ACE) genotypes and abdominal aortic aneurysm?

European Journal of Vascular and Endovascular Surgery

Volumn 40, Issue 4, 2010, Pages 457-460

  Obukofe, B ^a   Sayers, R D ^a   Thompson, J ^b   Sandford, R M ^a   London, N J M ^a   Samani, N J ^a   Bown, M J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

ACE; Aneurysm; Aorta; Cardiovascular disease; Genetics; MTHFR

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ABDOMINAL AORTA ANEURYSM; ADULT; AGED; ARTICLE; CONTROLLED STUDY; DNA EXTRACTION; FEMALE; GENE DELETION; GENE INSERTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 84859165381     PISSN: 10785884     EISSN: 15322165     Source Type: Journal    
DOI: 10.1016/j.ejvs.2010.06.013     Document Type: Article

References (12)

1. Jones GT, Thompson AR, van Bockxmeer FM, Hafez H, Cooper JA, Golledge J, et al. Angiotensin II type 1 receptor 1166C polymorphism is associated with abdominal aortic aneurysm in three independent cohorts. Arterioscler Thromb Vasc Biol 2008;28:764-70. (Pubitemid 351651328)
2. Thompson AR, Drenos F, Hafez H, Humphries SE. Candidate gene association studies in abdominal aortic aneurysm disease: A review and meta-analysis. Eur J Vasc Endovasc Surg 2008;35: 19-30. (Pubitemid 350235228)
3. Sandford RM, Bown MJ, London NJ, Sayers RD. The genetic basis of abdominal aortic aneurysms: A review. Eur J Vasc Endovasc Surg 2007;33(4):381-90. (Pubitemid 46336592)
4. Daugherty A, Rateri DL, Cassis LA. Role of the renin-angiotensin system in the development of abdominal aortic aneurysms in animals and humans. Ann N Y Acad Sci 2006;1085:82-91. (Pubitemid 47092006)
5. Huang W, Alhenc Gelas F, Osborne-Pellegrin MJ. Protection of the arterial internal elastic lamina by inhibition of the renin-angiotensin system in the rat. Circ Res 1998;82(8): 879-90. 4.
6. Hackam DG, Thiruchelvam D, Redelmeier DA. Angiotensin-converting enzyme inhibitors and aortic rupture: A populationbased case-control study. Lancet 2006;368:659-65. (Pubitemid 44226485)
7. Hamano K, Ohishi M, Ueda M, Fujioka K, Katoh T, Zempo N, et al. Deletion polymorphism in the gene for angiotensin-converting enzyme is not a risk factor predisposing to abdominal aortic aneurysm. Eur J Vasc Endovasc Surg 1999;18:158-61. (Pubitemid 29374027)
8. Pola R, Geatani E, Santoliquido A, Gerardino L, Cattani P, Serricchio M, et al. Abdominal aortic aneurysm in normotensive patients: Association with angiotensin-converting enzyme gene polymorphism. Eur J Vasc Endovasc Surg 2001;21:445-9. (Pubitemid 32519703)
9. Fatini C, Pratesi G, Sofi F, Gensini F, Sticchi E, Lari B, et al. ACE DD genotype: A predisposing factor for abdominal aortic aneurysm. Eur J Vasc Endovasc Surg 2005;29:227-32. (Pubitemid 40267958)
10. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661-78.
11. Bown MJ, Braund PS, Thompson J, London NJM, Samani NJ, Sayers RD. Association between the coronary artery disease risk locus on chromosome 9p21.3 and abdominal aortic aneurysm. Circ Cardiovasc Genetics 2008;1:39-42.
12. Helgadottir A, Thorleifsson G, Magnusson KP, Grétarsdottir S, Steinthorsdottir V, Manolescu A, et al. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nature Genetics 2008;40:217-24. (Pubitemid 351171400)