The age at motor symptoms onset in LRRK2-associated Parkinson's disease is affected by a variation in the MAPT locus: A possible interaction

Journal of Molecular Neuroscience

Volumn 46, Issue 3, 2012, Pages 541-544

  Gan Or, Ziv ^a,b   Bar Shira, Anat ^a   Mirelman, Anat ^a   Gurevich, Tanya ^a,b   Giladi, Nir ^a,b   Orr Urtreger, Avi ^a,b  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

LRRK2; MAPT; Parkinson's disease; Tau

Indexed keywords

LEUCINE RICH REPEAT KINASE 2; TAU PROTEIN;

ADULT; ALLELE; ARTICLE; BALANCE DISORDER; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE LOCUS; GENE MUTATION; GENOTYPE; HEREDITY; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; MOTOR DYSFUNCTION; MUSCLE STIFFNESS; ONSET AGE; PARKINSON DISEASE; SINGLE NUCLEOTIDE POLYMORPHISM; TREMOR;

ADULT; AGE OF ONSET; AGED; AGING; COHORT STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HETEROZYGOTE DETECTION; HUMANS; JEWS; MALE; MIDDLE AGED; PARKINSON DISEASE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; TAU PROTEINS;

EID: 84859159465     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9641-0     Document Type: Article

References (15)

1. Biernacka JM, Armasu SM, Cunningham JM, Eric Ahlskog J, Chung SJ, Maraganore DM (2011) Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson's disease susceptibility? Parkinsonism Relat Disord. doi:10.1016/j.parkreldis.2011.07.001
2. Cookson M (2010) The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease. Nat Rev Neurosci 11(12):791-797
3. Gan-Or Z, Giladi N, Rozovski U, Shifrin C, Rosner S, Gurevich T et al (2008) Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset. Neurology 70:2277-2283
4. Gan-Or Z, Bar-Shira A, Mirelman A, Gurevich T, Kedmi M, Giladi N et al (2010) LRRK2 and GBA mutations differentially affect the initial presentation of Parkinson disease. Neurogenetics 11:121-125
5. Gan-Or Z, Bar-Shira A, Gurevich T, Giladi N, Orr-Urtreger A (2011) Homozygosity for the MTX1 c.184T>A (p.S63T) alteration modifies the age at onset in GBA-associated Parkinson's disease. Neurogenetics. doi:10.1007/s10048- 011-0293-6
6. Giasson BI, Van Deerlin VM (2008) Mutations in LRRK2 as a cause of Parkinson's disease. Neurosignals 16:99-105
7. Golub Y, Berg D, Calne DB, Pfeiffer RF, Uitti RJ, Stoessl AJ et al (2009) Genetic factors influencing age at onset in LRRK2-linked Parkinson disease. Parkinsonism Relat Disord 15:539-541
8. Healy DG, Falchi M, O'Sullivan SS, Bonifati V, Durr A, Bressman S et al (2008) Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. Lancet Neurol 7(7):583-590
9. Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181-184
10. Melrose HL, Dachsel JC, Behrouz B, Lincoln SJ, Yue M, Hinkle KM et al (2010) Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice. Neurobiol Dis 40:503-517
11. Miklossy J, Qing H, Guo JP, Yu S, Wszolek ZK, Calne D et al (2007) Lrrk2 and chronic inflammation are linked to pallido-pontonigral degeneration caused by the N279K tau mutation. Acta Neuropathol 114:243-254 (Pubitemid 47226150)
12. Orr-Urtreger A, Shifrin C, Rozovski U, Rosner S, Bercovich D, Gurevich T et al (2007) The LRRK2 G2019S mutation in Ashkenazi Jews with Parkinson disease: is there a gender effect? Neurology 69:1595-1602 (Pubitemid 350287143)
13. Rajput A, Dickson DW, Robinson CA, Ross OA, Dachsel JC, Lincoln SJ et al (2006) Parkinsonism, Lrrk2 G2019S, and tau neuropathology. Neurology 67:1506-1508 (Pubitemid 44632090)
14. Simon-Sanchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D et al (2009) Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet 41:1308-1312
15. Skipper L, Wilkes K, Toft M, Baker M, Lincoln S, Hulihan M et al (2004) Linkage disequilibrium and association of MAPT H1 in Parkinson disease. Am J Hum Genet 75:669-677 (Pubitemid 39244781)