The effect of bone marrow microenvironment on the functional properties of the therapeutic bone marrow-derived cells in patients with acute myocardial infarction

Journal of Translational Medicine

Volumn 10, Issue 1, 2012, Pages

  Miettinen, Johanna A ^a   Salonen, Riikka J ^a   Ylitalo, Kari ^a   Niemelä, Matti ^a   Kervinen, Kari ^a   Säily, Marjaana ^a   Koistinen, Pirjo ^a   Savolainen, Eeva Riitta ^a   Mäkikallio, Timo H ^a   Huikuri, Heikki V ^a   Lehenkari, Petri ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

Blood gas analysis; Bone marrow stem cells; Cell therapy; Mesenchymal stem cells; Myocardial infarction

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; POTASSIUM; SODIUM;

ACUTE HEART INFARCTION; ADULT; ARTICLE; BLOOD CARBON DIOXIDE TENSION; BLOOD GAS ANALYSIS; BLOOD OXYGEN TENSION; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; ELECTROLYTE BLOOD LEVEL; ENZYME ACTIVITY; FEMALE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MALE; MESENCHYMAL STEM CELL; PH MEASUREMENT; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; AGED; AUTOTRANSPLANTATION; BONE MARROW; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL CULTURE; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; HEART INFARCTION; HEART STROKE VOLUME; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PILOT STUDY; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; TUMOR MICROENVIRONMENT; VASCULARIZATION;

ADULT; AGED; BLOOD GAS ANALYSIS; BONE MARROW; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELLS, CULTURED; CELLULAR MICROENVIRONMENT; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PILOT PROJECTS; PROGNOSIS; STROKE VOLUME; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84859133706     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-10-66     Document Type: Article

References (29)

1. George JC. Stem cell therapy in acute myocardial infarction: a review of clinical trials. Transl Res 2010, 155:10-19. 10.1016/j.trsl.2009.06.009, 20004357.
2. Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML. Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response. Sci Transl Med 2011, 3:100ra90. 10.1126/scitranslmed.3002814, 21918107.
3. Kirby BJ, McNicol MW. Acid-base status in acute myocardial infarction. Lancet 1966, 2:1054-1056.
4. Lazzeri C, Valente S, Chiostri M, Picariello C, Gensini GF. Evaluation of acid-base balance in ST-elevation myocardial infarction in the early phase: a prognostic tool?. Coron Artery Dis 2010, 21:266-272. 10.1097/MCA.0b013e32833b20c6, 20617567.
5. Grisham J, Hastings C. Bone marrow aspirate as an accessible and reliable source for critical laboratory studies. Ann Emerg Med 1991, 20:1121-1124. 10.1016/S0196-0644(05)81388-5, 1928886.
6. Huikuri HV, Kervinen K, Niemelä M, Ylitalo K, Säily M, Koistinen P, Savolainen ER, Ukkonen H, Pietilä M, Airaksinen JK, Knuuti J, Mäkikallio TH. Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction. Eur Heart J 2008, 29:2723-2732. 10.1093/eurheartj/ehn436, 18845667.
7. Miettinen JA, Pietilä M, Salonen RJ, Ohlmeier S, Ylitalo K, Huikuri HV, Lehenkari P. Tumor necrosis factor alpha promotes the expression of immunosuppressive proteins and enhances the cell growth in a human bone marrow-derived stem cell culture. Exp Cell Res 2011, 317:791-801. 10.1016/j.yexcr.2010.12.010, 21182837.
8. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006, 8:315-317. 10.1080/14653240600855905, 16923606.
9. Huikuri HV, Tapanainen JM, Lindgren K, Raatikainen P, Mäkikallio TH, Juhani Airaksinen KE, Myerburg RJ. Prediction of sudden cardiac death after myocardial infarction in the beta-blocking era. J Am Coll Cardiol 2003, 42:652-658. 10.1016/S0735-1097(03)00783-6, 12932596.
10. Falchuk KH, Goetzl EJ, Kulka JP. Respiratory gases of synovial fluids. An approach to synovial tissue circulatory-metabolic imbalance in rheumatoid arthritis. Am J Med 1970, 49:223-231. 10.1016/S0002-9343(70)80078-X, 5452943.
11. Bushinsky DA. Stimulated osteoclastic and suppressed osteoblastic activity in metabolic but not respiratory acidosis. Am J Physiol 1995, 268:C80-C88.
12. Frick KK, Bushinsky DA. In vitro metabolic and respiratory acidosis selectively inhibit osteoblastic matrix gene expression. Am J Physiol 1999, 277:F750-F755.
13. Brandao-Burch A, Utting JC, Orriss IR, Arnett TR. Acidosis inhibits bone formation by osteoblasts in vitro by preventing mineralization. Calcif Tissue Int 2005, 77:167-174. 10.1007/s00223-004-0285-8, 16075362.
14. Disthabanchong S, Radinahamed P, Stitchantrakul W, Hongeng S, Rajatanavin R. Chronic metabolic acidosis alters osteoblast differentiation from human mesenchymal stem cells. Kidney Int 2007, 71:201-209. 10.1038/sj.ki.5002035, 17183249.
15. Chen T, Zhou Y, Tan WS. Influence of lactic acid on the proliferation, metabolism, and differentiation of rabbit mesenchymal stem cells. Cell Biol Toxicol 2009, 25:573-586. 10.1007/s10565-008-9113-7, 19130272.
16. Britten MB, Abolmaali ND, Assmus B, Lehmann R, Honold J, Schmitt J, Vogl TJ, Martin H, Schachinger V, Dimmeler S, Zeiher AM. Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI): mechanistic insights from serial contrast-enhanced magnetic resonance imaging. Circulation 2003, 108:2212-2218. 10.1161/01.CIR.0000095788.78169.AF, 14557356.
17. Fernandez-Aviles F, San Roman JA, Garcia-Frade J, Fernandez ME, Penarrubia MJ, de la Fuente L, Gomez-Bueno M, Cantalapiedra A, Fernandez J, Gutierrez O, Sanchez PL, Hernandez C, Sanz R, Garcia-Sancho J, Sanchez A. Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Circ Res 2004, 95:742-748. 10.1161/01.RES.0000144798.54040.ed, 15358665.
18. Lunde K, Solheim S, Aakhus S, Arnesen H, Abdelnoor M, Egeland T, Endresen K, Ilebekk A, Mangschau A, Fjeld JG, Smith HJ, Taraldsrud E, Grogaard HK, Bjornerheim R, Brekke M, Muller C, Hopp E, Ragnarsson A, Brinchmann JE, Forfang K. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med 2006, 355:1199-1209. 10.1056/NEJMoa055706, 16990383.
19. Miettinen JA, Ylitalo K, Hedberg P, Jokelainen J, Kervinen K, Niemelä M, Säily M, Koistinen P, Savolainen ER, Ukkonen H, Pietilä M, Airaksinen KE, Knuuti J, Vuolteenaho O, Mäkikallio TH, Huikuri HV. Determinants of functional recovery after myocardial infarction of patients treated with bone marrow-derived stem cells after thrombolytic therapy. Heart 2010, 96:362-367. 10.1136/hrt.2009.171694, 19910293.
20. Grayson WL, Zhao F, Bunnell B, Ma T. Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells. Biochem Biophys Res Commun 2007, 358:948-953. 10.1016/j.bbrc.2007.05.054, 17521616.
21. Ueyama H, Horibe T, Hinotsu S, Tanaka T, Inoue T, Urushihara H, Kitagawa A, Kawakami K. Chromosomal variability of human mesenchymal stem cells cultured under hypoxic conditions. J Cell Mol Med 2012, 16:72-82. 10.1111/j.1582-4934.2011.01303.x, 21418515.
22. Trentin JJ. Determination of bone marrow stem cell differentiation by stromal hemopoietic inductive microenvironments (HIM). Am J Pathol 1971, 65:621-628. 2047588, 4941071.
23. Askmyr M, Sims NA, Martin TJ, Purton LE. What is the true nature of the osteoblastic hematopoietic stem cell niche?. Trends Endocrinol Metab 2009, 20:303-309. 10.1016/j.tem.2009.03.004, 19595609.
24. Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H, Zeiher AM, Dimmeler S. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 2001, 89:E1-E7. 10.1161/hh1301.093953, 11440984.
25. Tepper OM, Galiano RD, Capla JM, Kalka C, Gagne PJ, Jacobowitz GR, Levine JP, Gurtner GC. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 2002, 106:2781-2786. 10.1161/01.CIR.0000039526.42991.93, 12451003.
26. Dimmeler S, Leri A. Aging and disease as modifiers of efficacy of cell therapy. Circ Res 2008, 102:1319-1330. 10.1161/CIRCRESAHA.108.175943, 2728476, 18535269.
27. Heeschen C, Lehmann R, Honold J, Assmus B, Aicher A, Walter DH, Martin H, Zeiher AM, Dimmeler S. Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease. Circulation 2004, 109:1615-1622. 10.1161/01.CIR.0000124476.32871.E3, 15037527.
28. Kissel CK, Lehmann R, Assmus B, Aicher A, Honold J, Fischer-Rasokat U, Heeschen C, Spyridopoulos I, Dimmeler S, Zeiher AM. Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. J Am Coll Cardiol 2007, 49:2341-2349. 10.1016/j.jacc.2007.01.095, 17572250.
29. Pietilä M, Palomäki S, Lehtonen S, Ritamo I, Valmu L, Nystedt J, Laitinen S, Leskelä HV, Sormunen R, Pesälä J, Nordstrom K, Vepsäläinen A, Lehenkari P. Mitochondrial Function and Energy Metabolism in Umbilical Cord Blood- and Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells Dev 2012, 21:575-588. 10.1089/scd.2011.0023, 21615273.