-
1
-
-
0037186924
-
Imatinib mesylate - A new oral targeted therapy
-
DOI 10.1056/NEJMra013339
-
Savage DG, Antman KH: Imatinib mesylate -a new oral targeted therapy. N Engl J Med 2002; 346: 683-693 (Pubitemid 34815874)
-
(2002)
New England Journal of Medicine
, vol.346
, Issue.9
, pp. 683-693
-
-
Savage, D.G.1
Antman, K.H.2
-
2
-
-
77949767505
-
International Randomized Study of Interferon vs STI571 (IRIS) 8-year follow up: Sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib
-
ASH Annual Meeting Abstracts
-
Deininger M, O'Brien SG, Guilhot F, Goldman JM, Hochhaus A, Hughes TP, Radich JP, Hatfield AK, Mone M, Filian J, Reynolds J, Gathmann I, Larson RA, Druker BJ: International Randomized Study of Interferon vs STI571 (IRIS) 8-year follow up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib. ASH Annual Meeting Abstracts. Blood 2009; 114: 1126
-
(2009)
Blood
, vol.114
, pp. 1126
-
-
Deininger, M.1
O'brien, S.G.2
Guilhot, F.3
Goldman, J.M.4
Hochhaus, A.5
Hughes, T.P.6
Radich, J.P.7
Hatfield, A.K.8
Mone, M.9
Filian, J.10
Reynolds, J.11
Gathmann, I.12
Larson, R.A.13
Druker, B.J.14
-
3
-
-
0036874198
-
BCR/ABL amplification in chronic myelocytic leukemia blast crisis following imatinib mesylate administration
-
DOI 10.1016/S0165-4608(02)00615-5, PII S0165460802006155
-
Campbell LJ, Patsouris C, Rayeroux KC, Somana K, Januszewicz EH, Szer J: BCR/ABL amplification in chronic myelocytic leukemia blast crisis following imatinib mesylate administration. Cancer Genet Cytogenet 2002; 139: 30-33 (Pubitemid 36120403)
-
(2002)
Cancer Genetics and Cytogenetics
, vol.139
, Issue.1
, pp. 30-33
-
-
Campbell, L.J.1
Patsouris, C.2
Rayeroux, K.C.3
Somana, K.4
Januszewicz, E.H.5
Szer, J.6
-
4
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
DOI 10.1126/science.1062538
-
Gorre ME, Mohammed M, Ellwood K, Hsu N, Paquette R, Rao PN, Sawyers CL: Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001; 293: 876-880 (Pubitemid 32743979)
-
(2001)
Science
, vol.293
, Issue.5531
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
Hsu, N.4
Paquette, R.5
Nagesh Rao, P.6
Sawyers, C.L.7
-
5
-
-
31344472945
-
Novel targeted therapies to overcome imatinib mesylate resistance in chronic myeloid leukemia (CML)
-
DOI 10.1016/j.critrevonc.2005.06.007, PII S1040842805001459
-
Walz C, Sattler M: Novel targeted therapies to overcome imatinib mesylate resistance in chronic myeloid leukemia (CML). Crit Rev Oncol Hematol 2006; 57: 145-164 (Pubitemid 43140744)
-
(2006)
Critical Reviews in Oncology/Hematology
, vol.57
, Issue.2
, pp. 145-164
-
-
Walz, C.1
Sattler, M.2
-
6
-
-
34147174980
-
Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia
-
DOI 10.1182/blood-2006-07-036012
-
Picard S, Titier K, Etienne G, Teilhet E, Ducint D, Bernard MA, Lassalle R, Marit G, Reiffers J, Begaud B, Moore N, Molimard M, Mahon FX: Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia. Blood 2007; 109: 3496-3499 (Pubitemid 46572540)
-
(2007)
Blood
, vol.109
, Issue.8
, pp. 3496-3499
-
-
Picard, S.1
Titier, K.2
Etienne, G.3
Teilhet, E.4
Ducint, D.5
Bernard, M.-A.6
Lassalle, R.7
Marit, G.8
Reiffers, J.9
Begaud, B.10
Moore, N.11
Molimard, M.12
Mahon, F.-X.13
-
8
-
-
41449106741
-
Monitoring treatment of chronic myeloid leukemia
-
Baccarani M, Pane F, Saglio G: Monitoring treatment of chronic myeloid leukemia. Haematologica 2008; 93: 161-169
-
(2008)
Haematologica
, vol.93
, pp. 161-169
-
-
Baccarani, M.1
Pane, F.2
Saglio, G.3
-
10
-
-
33745603988
-
Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: Review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results
-
DOI 10.1182/blood-2006-01-0092
-
Hughes T, Deininger M, Hochhaus A, Branford S, Radich J, Kaeda J, Baccarani M, Cortes J, Cross NC, Druker BJ, Gabert J, Grimwade D, Hehlmann R, Kamel-Reid S, Lipton JH, Longtine J, Martinelli G, Saglio G, Soverini S, Stock W, Goldman JM: Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 2006; 108: 28-37 (Pubitemid 43990609)
-
(2006)
Blood
, vol.108
, Issue.1
, pp. 28-37
-
-
Hughes, T.1
Deininger, M.2
Hochhaus, A.3
Branford, S.4
Radich, J.5
Kaeda, J.6
Baccarani, M.7
Cortes, J.8
Cross, N.C.P.9
Druker, B.J.10
Gabert, J.11
Grimwade, D.12
Hehlmann, R.13
Kamel-Reid, S.14
Lipton, J.H.15
Longtine, J.16
Martinelli, G.17
Saglio, G.18
Soverini, S.19
Stock, W.20
Goldman, J.M.21
more..
-
11
-
-
0037022751
-
High-throughput quantification of the anti-leukemia drug STI571 (Gleevec™) and its main metabolite (CGP 74588) in human plasma using liquid chromatography-tandem mass spectrometry
-
DOI 10.1016/S1570-0232(01)00611-0, PII S1570023201006110
-
Bakhtiar R, Lohne J, Ramos L, Khemani L, Hayes M, Tse F: High-throughput quantification of the anti-leukemia drug STI571 (Gleevec) and its main metabolite (CGP 74588) in human plasma using liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 768: 325-340 (Pubitemid 34158868)
-
(2002)
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
, vol.768
, Issue.2
, pp. 325-340
-
-
Bakhtiar, R.1
Lohne, J.2
Ramos, L.3
Khemani, L.4
Hayes, M.5
Tse, F.6
-
12
-
-
0036094117
-
Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia
-
Cohen MH, Williams G, Johnson JR, Duan J, Gobburu J, Rahman A, Benson K, Leighton J, Kim SK, Wood R, Rothmann M, Chen G, U KM, Staten AM, Pazdur R: Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia. Clin Cancer Res 2002; 8: 935-942 (Pubitemid 34520420)
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.5
, pp. 935-942
-
-
Cohen, M.H.1
Williams, G.2
Johnson, J.R.3
Duan, J.4
Gobburu, J.5
Rahman, A.6
Benson, K.7
Leighton, J.8
Kim, S.K.9
Wood, R.10
Rothmann, M.11
Chen, G.12
U, K.M.13
Staten, A.M.14
Pazdur, R.15
-
13
-
-
9444282642
-
Active transport of imatinib into and out of cells: Implications for drug resistance
-
DOI 10.1182/blood-2003-12-4276
-
Thomas J, Wang L, Clark RE, Pirmohamed M: Active transport of imatinib into and out of cells: implications for drug resistance. Blood 2004; 104: 3739-3745 (Pubitemid 39564452)
-
(2004)
Blood
, vol.104
, Issue.12
, pp. 3739-3745
-
-
Thomas, J.1
Wang, L.2
Clark, R.E.3
Pirmohamed, M.4
-
14
-
-
43249083718
-
Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: A subanalysis of the IRIS study
-
Larson RA, Druker BJ, Guilhot F, O'Brien SG, Riviere GJ, Krahnke T, Gathmann I, Wang Y: Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study. Blood 2008; 111: 4022-4028
-
(2008)
Blood
, vol.111
, pp. 4022-4028
-
-
Larson, R.A.1
Druker, B.J.2
Guilhot, F.3
O'brien, S.G.4
Riviere, G.J.5
Krahnke, T.6
Gathmann, I.7
Wang, Y.8
-
15
-
-
67349238791
-
Correlation between trough imatinib plasma concentration and clinical response in chronic myeloid leukemia
-
Mahon FX, Molimard M: Correlation between trough imatinib plasma concentration and clinical response in chronic myeloid leukemia. Leuk Res 2009; 33: 1147-1150
-
(2009)
Leuk Res
, vol.33
, pp. 1147-1150
-
-
Mahon, F.X.1
Molimard, M.2
-
16
-
-
33745085275
-
OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): Reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib
-
DOI 10.1182/blood-2005-11-4687
-
White DL, Saunders VA, Dang P, Engler J, Zannettino AC, Cambareri AC, Quinn SR, Manley PW, Hughes TP: OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib. Blood 2006; 108: 697-704 (Pubitemid 44061372)
-
(2006)
Blood
, vol.108
, Issue.2
, pp. 697-704
-
-
White, D.L.1
Saunders, V.A.2
Dang, P.3
Engler, J.4
Zannettino, A.C.W.5
Cambareri, A.C.6
Quinn, S.R.7
Manley, P.W.8
Hughes, T.P.9
-
17
-
-
34547946755
-
Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats
-
DOI 10.1080/00498250701546012, PII 781351000
-
Umehara KI, Iwatsubo T, Noguchi K, Kamimura H: Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats. Xenobiotica 2007; 37: 818-831 (Pubitemid 47267805)
-
(2007)
Xenobiotica
, vol.37
, Issue.8
, pp. 818-831
-
-
Umehara, K.-I.1
Iwatsubo, T.2
Noguchi, K.3
Kamimura, H.4
-
18
-
-
37049028176
-
Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: Higher doses of imatinib may overcome the negative impact of low OCT-1 activity
-
DOI 10.1182/blood-2007-06-093617
-
White DL, Saunders VA, Dang P, Engler J, Venables A, Zrim S, Zannettino A, Lynch K, Manley PW, Hughes T: Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity. Blood 2007; 110: 4064-4072 (Pubitemid 350248463)
-
(2007)
Blood
, vol.110
, Issue.12
, pp. 4064-4072
-
-
White, D.L.1
Saunders, V.A.2
Dang, P.3
Engler, J.4
Venables, A.5
Zrim, S.6
Zannettino, A.7
Lynch, K.8
Manley, P.W.9
Hughes, T.10
-
19
-
-
68549084355
-
CML patients with low OCT-1 activity achieve better molecular responses on high dose imatinib than on standard dose. Those with High OCT-1 activity have excellent responses on either dose: A TOPS correlative study. ASH Annual Meeting Abstracts
-
White DL, Saunders VA, Dang P, Frede A, Eadie L, Soverini S, Quarantelli F, Lin P, Thornquist M, Kim D, Pane F, Martinelli G, Radich J, Kalebic T, Saglio G, Hughes T: CML patients with low OCT-1 activity achieve better molecular responses on high dose imatinib than on standard dose. Those with high OCT-1 activity have excellent responses on either dose: a TOPS correlative study. ASH Annual Meeting Abstracts. Blood 2008; 112: 3187
-
(2008)
Blood
, vol.112
, pp. 3187
-
-
White, D.L.1
Saunders, V.A.2
Dang, P.3
Frede, A.4
Eadie, L.5
Soverini, S.6
Quarantelli, F.7
Lin, P.8
Thornquist, M.9
Kim, D.10
Pane, F.11
Martinelli, G.12
Radich, J.13
Kalebic, T.14
Saglio, G.15
Hughes, T.16
-
20
-
-
36049029703
-
The role of efflux pumps in drug-resistant metastatic breast cancer: New insights and treatment strategies
-
Fojo T, Coley HM: The role of efflux pumps in drug-resistant metastatic breast cancer: new insights and treatment strategies. Clin Breast Cancer 2007; 7: 749-756 (Pubitemid 350086119)
-
(2007)
Clinical Breast Cancer
, vol.7
, Issue.10
, pp. 749-756
-
-
Fojo, T.1
Coley, H.M.2
-
21
-
-
0345724724
-
The MRP family of drug efflux pumps
-
DOI 10.1038/sj.onc.1206953, Drug Resistance
-
Mao Q, Unad, Kruh GD, Belinsky MG: The MRP family of drug efflux pumps. Oncogene 2003; 22: 7537-7552 (Pubitemid 37487175)
-
(2003)
Oncogene
, vol.22
, Issue.REV. ISS. 6
, pp. 7537-7552
-
-
Kruh, G.D.1
Belinsky, M.G.2
-
22
-
-
27644480743
-
Role of the breast cancer resistance protein (ABCG2) in drug transport
-
kat JD: Role of the breast cancer resistance protein (ABCG2) in drug transport. AAPS J 2005; 7:E118-E133
-
(2005)
AAPS J
, vol.7
-
-
Kat, J.D.1
-
23
-
-
0344520475
-
Distribution of STI-571 to the brain is limited by P-glycoprotein- mediated efflux
-
DOI 10.1124/jpet.102.045260
-
Dai H, Marbach P, Lemaire M, Hayes M, Elmquist WF: Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux. J Pharmacol Exp Ther 2003; 304: 1085-1092 (Pubitemid 36254421)
-
(2003)
Journal of Pharmacology and Experimental Therapeutics
, vol.304
, Issue.3
, pp. 1085-1092
-
-
Dai, H.1
Marbach, P.2
Lemaire, M.3
Hayes, M.4
Elmquist, W.F.5
-
24
-
-
84861223657
-
Efflux of the tyrosine kinase inhibitors imatinib and nilotinib (AMN107) is mediated by ABCB1 (MDR1)-type P-glycoprotein
-
ASH Annual Meeting Abstracts
-
Dohse M, Robey RW, Brendel C, Bates S, Neubauer A, Scharenberg C: Efflux of the tyrosine kinase inhibitors imatinib and nilotinib (AMN107) is mediated by ABCB1 (MDR1)-type P-glycoprotein. ASH Annual Meeting Abstracts. Blood 2006; 108: 1367
-
(2006)
Blood
, vol.108
, pp. 1367
-
-
Dohse, M.1
Robey, R.W.2
Brendel, C.3
Bates, S.4
Neubauer, A.5
Scharenberg, C.6
-
25
-
-
1542713480
-
P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate
-
DOI 10.1038/sj.leu.2403257
-
Illmer T, Schaich M, Platzbecker U, Freiberg-Richter J, Oelschlagel U, von Bonin M, Pursche S, Bergemann T, Ehninger G, Schleyer E: P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate. Leukemia 2004; 18: 401-408 (Pubitemid 38425851)
-
(2004)
Leukemia
, vol.18
, Issue.3
, pp. 401-408
-
-
Illmer, T.1
Schaich, M.2
Platzbecker, U.3
Freiberg-Richter, J.4
Oelschlagel, U.5
Von Bonin, M.6
Pursche, S.7
Bergemann, T.8
Ehninger, G.9
Schleyer, E.10
-
26
-
-
0037443754
-
MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models
-
DOI 10.1182/blood.V101.6.2368
-
Mahon FX, Belloc F, Lagarde V, Chollet C, Moreau-Gaudry F, Reiffers J, Goldman JM, Melo JV: MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. Blood 2003; 101: 2368-2373 (Pubitemid 36304670)
-
(2003)
Blood
, vol.101
, Issue.6
, pp. 2368-2373
-
-
Mahon, F.-X.1
Belloc, F.2
Lagarde, V.3
Chollet, C.4
Moreau-Gaudry, F.5
Reiffers, J.6
Goldman, J.M.7
Melo, J.V.8
-
27
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
DOI 10.1056/NEJM200104053441401
-
Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers CL: Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344: 1031-1037 (Pubitemid 32267972)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.14
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.L.11
-
28
-
-
24344482346
-
Clinical pharmacokinetics of imatinib
-
DOI 10.2165/00003088-200544090-00001
-
Peng B, Lloyd P, Schran H: Clinical pharmacokinetics of imatinib. Clin Pharmacokinet 2005; 44: 879-894. (Pubitemid 41252840)
-
(2005)
Clinical Pharmacokinetics
, vol.44
, Issue.9
, pp. 879-894
-
-
Peng, B.1
Lloyd, P.2
Schran, H.3
|