Capillary microsampling of 25 μl blood for the determination of toxicokinetic parameters in regulatory studies in animals

Bioanalysis

Volumn 4, Issue 6, 2012, Pages 661-674

  Jonsson, Ove ^a   Villar, Rodrigo Palma ^a   Nilsson, Lars B ^b   Norsten Höög, Carina ^a   Brogren, Jacob ^a   Eriksson, Marie ^a   Königsson, Kristian ^a   Samuelsson, Anders ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

EDETIC ACID;

ACCURACY; ANALYTIC METHOD; ARTICLE; BLOOD SAMPLING; BLOOD VOLUME; CAPILLARY BLOOD; CAPILLARY MICROSAMPLING; CONTROLLED STUDY; DOG; FEMALE; FREEZE THAWING; HUMAN; IN VITRO STUDY; LABORATORY AUTOMATION; LABORATORY TEST; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MOLECULAR STABILITY; NONHUMAN; RAT; SPECIES COMPARISON; TOXICOKINETICS; VALIDATION PROCESS;

ANIMALS; AREA UNDER CURVE; BIOLOGICAL MARKERS; BLOOD SPECIMEN COLLECTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; DRUG TOXICITY; MASS SPECTROMETRY; RATS;

EID: 84859124125     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.12.25     Document Type: Article

References (13)

1. US Department of Health and Human Services. FDA, CDER, Center for Veterinary Medicine (CVM): Guidance for Industry. Bioanalytical Method Validation (2001).
2. Li W, Tse FLS. Dried blood spot sampling in combination with LC-MS/MS for quantitative analysis of small molecules. Biomed. Chrom. 24, 49-65 (2010).
3. Edelbroek PM, van der Heijden J, Stolk LML. Dried blood spot methods in therapeutic drug monitoring: methods, assays, and pitfalls. Ther. Drug. Monit. 31, 327-336 (2009).
4. Emmons G, Rowland M. Pharmacokinetic considerations as to when to use dried blood spot sampling. Bioanalysis 11, 1791-1796 (2010). Useful article for choosing between blood and plasma exposure.
5. Smith CJ, Sykes A, Robinson S, Thomas E. Evaluation of blood microsampling techniques and sampling sites for the analysis of drugs by HPLC-MS. Bioanalysis 2, 145-156 (2011).
6. Nilsson LB, Schmidt S. Simultaneous determination of total and free drug plasma concentrations combined with batch-wise pH-adjustment for the free concentration determinations. J. Pharm. Biomed. Anal. 24, 921-927 (2001).
7. Jacobson B-M, Olsson A, Fakt C, Öhman D. The use of human plasma as matrix for calibration standards in preclinical LC-MS/MS methods. A way to reduce animal use, J. Pharm. Biomed. Anal. 54, 826-829 (2011).
8. Diehl KH, Hull R, Morton D et al. A good practice guide to the administration of substances and removal of blood, including routes and volumes. J. Appl. Toxicol. 21, 15-23 (2001).
9. Timmerman P, White S, Globig S et al. EBF and dry blood spots: from recommendation to potential resolution. Bioanalysis 3 (16), 1787-1789 (2011).
10. Kissinger PT. Thinking about dry blood spots for pharmacokinetic assays and therapeutic drug monitoring. Bioanalysis 3 (20), 2263-2266 (2011).
11. O'Broin S. Influence of hematocrit on quantitative analysis of 'blood spots' on filter paper. Clin. Chem. 39, 1354-1355 (1993).
12. Adam BW, Alexander JR, Smith SJ et al. Recoveries of phenylanaline from two sets of dried blood spot reference materials: Prediction from hematocrit, spot volume and paper matrix. Clin. Chem. 46, 126-128 (2000).
13. Denniff P, Spooner N. The effect of hematocrit on assay bias when using DBS samples for the quantitative bioanalysis of drugs. Bioanalysis 2, 1385-1395 (2010).