The fungicide mancozeb induces toxic effects on mammalian granulosa cells

Toxicology and Applied Pharmacology

Volumn 260, Issue 2, 2012, Pages 155-161

  Paro, Rita ^a   Tiboni, Gian Mario ^b   Buccione, Roberto ^c   Rossi, Gianna ^a   Cellini, Valerio ^a   Canipari, Rita ^d   Cecconi, Sandra ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c Laboratorio Angela Valenti dei Fattori Genetici e Ambientali di Rischio Trombotico   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Granulosa cells; Human; Mancozeb; Mouse; p53

Indexed keywords

DACTINOMYCIN; MANCOZEB; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELL STRESS; CELL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSKELETON; EXTRACELLULAR MATRIX; GRANULOSA CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OVARY FOLLICLE; PROTEIN CONTENT; PROTEIN EXPRESSION; REPRODUCTIVE TOXICITY;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; FEMALE; FUNGICIDES, INDUSTRIAL; GRANULOSA CELLS; HUMANS; MANEB; MICE; MICROSCOPY, CONFOCAL; OVARIAN FOLLICLE; TUMOR SUPPRESSOR PROTEIN P53; ZINEB;

MAMMALIA; MUS;

EID: 84859107318     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.02.005     Document Type: Article

References (37)

1. Alexandrova A., Ivanov A., Chumakov P., Kopnin B., Vasiliev J. Changes in p53 expression in mouse fibroblasts can modify motility and extracellular matrix organization. Oncogene 2000, 19:5826-5830.
2. Axelstad M., Boberg J., Nellemann C., Kiersgaard M., Jacobsen P.R., Christiansen S., Hougaard K.S., Hass U. Exposure to the widely used fungicide mancozeb causes thyroid hormone disruption in rat dams but no behavioral effects in the offspring. Toxicol. Sci. 2011, 120:439-446.
3. Baldassarre M., Pompeo A., Beznoussenko G., Castaldi C., Cortellino S., McNiven M.A., Luini A., Buccione R. Dynamin participates in focal extracellular matrix degradation by invasive cells. Mol. Biol. Cell 2003, 14:1074-1084.
4. Belpoggi F., Soffritti M., Guarino M., Lambertini L., Cevolani D., Maltoni C. Results of long-term experimental studies on the carcinogenicity of ethylene-bis-dithiocarbamate (mancozeb) in rats. Ann. N. Y. Acad. Sci. 2002, 982:123-136.
5. Bowden E.T., Coopman P.J., Mueller S.C. Invadopodia: unique methods for measurement of extracellular matrix degradation in vitro. Methods Cell Biol. 2001, 63:613-627.
6. Calvert G.M., Alarcon W.A., Chelminski A., Crowley M.S., Barrett R., Correa A., Higgins S., Leon H.L., Correia J., Becker A., Allen R.H., Evans E. Case report: three farmworkers who gave birth to infants with birth defects closely grouped in time and place-Florida and North Carolina, 2004-2005. Environ. Health Perspect. 2007, 115:787-791.
7. Calviello G., Piccioni E., Boninsegna A., Tedesco B., Maggiano N., Serini S., Wolf F.I., Palozza P. DNA damage and apoptosis induction by the pesticide mancozeb in rat cells: involvement of the oxidative mechanism. Toxicol. Appl. Pharmacol. 2006, 211:87-96.
8. Can A., Albertini D.F. Stage specific effects of carbendazim (MBC) on meiotic cell cycle progression in mouse oocytes. Mol. Reprod. Dev. 1997, 46:351-362.
9. Cecconi S., Paro R., Rossi G., Macchiarelli G. The effects of the endocrine disruptors dithiocarbamates on the mammalian ovary with particular regard to mancozeb. Curr. Pharm. Des. 2007, 13:2989-3004.
10. Chhabra R.S., Eustis S., Haseman J.K., Kurtz P.J., Carlton B.D. Comparative carcinogenicity of ethylene thiourea with or without perinatal exposure in rats and mice. Fundam. Appl. Toxicol. 1992, 18:405-417.
11. Colosio C., Barcellini W., Maroni M., Alcini D., Bersani M., Cavallo D., Galli A., Meroni P., Pastorelli R., Rizzardi G.P., Soleo L., Foà V. Immunomodulatory effects of occupational exposure to mancozeb. Arch. Environ. Health 1996, 51:445-451.
12. Corsini E., Viviani B., Birindelli S., Gilardi F., Torri A., Codecà I., Lucchi L., Bartesaghi S., Galli C.L., Marinovich M., Colosio C. Molecular mechanisms underlying mancozeb-induced inhibition of TNF-alpha production. Toxicol. Appl. Pharmacol. 2006, 212:89-98.
13. Domico L.M., Zeevalk G.D., Bernard L.P., Cooper K.R. Acute neurotoxic effects of mancozeb and Maneb in mesencephalic neuronal cultures are associated with mitochondrial dysfunction. Neurotoxicology 2006, 27:816-825.
14. Gadéa G., Lapasset L., Gauthier-Rouvière C., Roux P. Regulation of Cdc42-mediated morphological effects: a novel function for p53. EMBO J. 2002, 21:2373-2382.
15. Greenlee A.R., Ellis T.M., Berg R.L. Low-dose agrochemicals and lawn-care pesticides induce developmental toxicity in murine preimplantation embryos. Environ. Health Perspect. 2004, 112:703-709.
16. Guo F., Zheng Y. Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion. Oncogene 2004, 23:5577-5585.
17. Guo F., Gao Y., Wang L., Zheng Y. p19Arf-p53 tumor suppressor pathway regulates cell motility by suppression of phosphoinositide 3-kinase and Rac1 GTPase activities. J. Biol. Chem. 2003, 278:14414-14419.
18. IARC Ethylene thiourea. IARC Mongr. Eval. Carcinog. Risks Hum. 2001, 79:659-701.
19. Kaur G., Belotti D., Burger A.M., Fisher-Nielson K., Borsotti P., Riccardi E., Thillainathan J., Hollingshead M., Sausville E.A., Giavazzi R. Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldamycin: an orally bioavailable heat shock protein 90 modulator. Clin. Cancer Res. 2004, 10:4813-4821.
20. Leiphon L.J., Picklo M.J. Inhibition of aldehyde detoxification in CNS mitochondria by fungicides. Neurotoxicology 2007, 28:143-149.
21. Lim Y.P., Lim T.T., Chan Y.L., Song A.C., Yeo B.H., Vojtesek B., Coomber D., Rajagopal G., Lane D. The p53 konwledgebase: an integrated information resource for p53 research. Oncogene 2007, 26:1517-1521.
22. Morelli M.B., Barberi M., Gambardella A., Borini A., Cecconi S., Coticchio G., Canipari R. Characterization, expression, and functional activity of pituitary adenylate cyclase-activating polypeptide and its receptors in human granulosa-luteal cells. J. Clin. Endocrinol. Metab. 2008, 93:4924-4932.
23. Muller P.A., Vousden K.H., Norman J.C. p53 and its mutants in tumor cell migration and invasion. J. Cell Biol. 2011, 192:209-218.
24. Nordby K.C., Andersen A., Irgens L.M., Kristensen P. Indicators of mancozeb exposure in relation to thyroid cancer and neural tube defects in farmers' families. Scand. J. Environ. Health 2005, 31:89-96.
25. Pocar P., Brevini T.A., Fischer B., Gandolfi F. The impact of the endocrine disruptors on oocyte competence. Reproduction 2003, 125:313-325.
26. Rossi G., Buccione R., Macchiarelli G., Palmerini M.G., Cecconi S. Mancozeb exposure in vivo impairs mouse oocyte fertilizability. Reprod. Toxicol. 2006, 21:216-219.
27. Rossi G., Palmerini M.G., Macchiarelli G., Buccione R., Cecconi S. Mancozeb adversely affects meiotic spindle organization and fertilization in mouse oocytes. Reprod. Toxicol. 2006, 22:51-55.
28. Schumer S.T., Cannistra S.A. Granulosa cell tumor of the ovary. J. Clin. Oncol. 2003, 21:1180-1189.
29. Shizukuda Y., Tang S., Yokota R., Ware J.A. Vascular endothelial growth factor-unduced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cσ activity. Circ. Res. 1999, 85:247-256.
30. Sottani C., Bettinelli M., Lorena Fiorentino M., Minoia C. Analytical method for the quantitative determination of urinary ethylenethiourea by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2003, 17:2253-2259.
31. Tyagi S., George J., Singh R., Bhui K., Shukla Y. Neoplastic alterations induced in mammalian skin following mancozeb exposure using in vivo and in vitro models. OMICS 2011, 15:155-167.
32. Ethylene Thiourea 96-45-7. Technology Transfer Network Air Toxics Web Site 1992 (Revised January 2000), U.S. EPA.
33. Drinking Water Standards and Health Advisories Table 2007, U.S. EPA.
34. Vaccari S., Latini S., Barberi M., Teti A., Stefanini M., Canipari R. Characterization and expression of different pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide receptors in rat ovarian follicles. J. Endocrinol. 2006, 191:287-299.
35. WHO Dithiocarbamates Pesticides Ethylenethiourea, and Propylenenthiourea: A General Introduction. Environ Health Criteria 78 Geneva 1988, World Health Organization, 17-02.
36. Yamakawa S., Asai T., Uchida T., Matsukawa M., Akizawa T., Oku N. (-)-Epigallocatechin gallate inhibits membrane-type 1 matrix metalloproteinase, MT1-MMP, and tumor angiogenesis. Cancer Lett. 2004, 210:47-55.
37. Zuccotti M., Merico V., Cecconi S., Redi C.A., Garagna S. What does it take to make a developmentally competent mammalian egg?. Hum. Reprod. Update 2011, 17:525-540.