Herpes Simplex i virus impairs regenerative outcomes of periodontal regenerative therapy in intrabony defects. A pilot study

Journal of Clinical Periodontology

Volumn 39, Issue 4, 2012, Pages 385-392

  Bertoldi, Carlo ^a,e   Pellacani, Chiara ^a   Lalla, Michele ^a   Consolo, Ugo ^a   Pinti, Marcello ^a   Cortellini, Pierpaolo ^b,c   Cossarizza, Andrea ^a,d  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b Accademia Toscana di Ricerca Odontostomatologica (ATRO)   (Italy)

^c European Research Group on Periodontology ERGOPerio   (Switzerland)

^d UNIVERSITY OF VALENCIA   (Spain)

^e Dipartimento di Chirurgie Specialistiche   (Italy)

Author keywords

biomolecular assay; enamel matrix derivative; herpes simplex virus 1; herpesvirus; intrabony defect; minimally invasive surgical technique; periodontitis; periodontopathogenic bacteria; real time PCR; regenerative therapy

Indexed keywords

ENAMEL MATRIX PROTEINS; ENAMEL PROTEIN; VIRUS DNA;

ADULT; ALVEOLAR BONE LOSS; ARTICLE; BONE REGENERATION; CHRONIC PERIODONTITIS; FEMALE; GINGIVA DISEASE; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; MALE; MIDDLE AGED; NONPARAMETRIC TEST; PERIODONTAL POCKET; PERIODONTICS; PHYSIOLOGY; TREATMENT OUTCOME; VIROLOGY;

ADULT; ALVEOLAR BONE LOSS; BONE REGENERATION; CHRONIC PERIODONTITIS; DENTAL ENAMEL PROTEINS; DNA, VIRAL; FEMALE; GINGIVAL RECESSION; GUIDED TISSUE REGENERATION, PERIODONTAL; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HUMANS; MALE; MIDDLE AGED; PERIODONTAL POCKET; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84859099712     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2012.01850.x     Document Type: Article

References (52)

1. Aass, A. M., Preus, H. R., Zambon, J. J., &, Gjermo, P., (1994) Microbiologic tests in epidemiologic studies: are they reproducible? Scandinavian Journal of Dental Research 102, 355-360.
2. Bilichodmath, S., Mangalekar, S. B., Sharma, D. C., Prabhakar, A. K., Reddy, S. B., Kalburgi, N. B., Patil, S. R., &, Bhat, K., (2009) Herpesviruses in chronic and aggressive periodontitis patients in an Indian population. Journal of Oral Science 51, 79-86.
3. Botero, J. E., Contreras, A., &, Parra, B., (2008) Effects of cytomegalovirus infection on the mRNA expression of collagens and matrix metalloproteinases in gingival fibroblasts. Journal of Periodontal Research 43, 649-657.
4. Botero, J. E., Parra, B., Jaramillo, A., &, Contreras, A., (2007) Subgingival human cytomegalovirus correlates with increased clinical periodontal parameters and bacterial coinfection in periodontitis. Journal of Periodontology 78, 2303-2310.
5. Chazan, B., Shaabi, M., Bishara, E., Colodner, R., &, Raz, R., (2003) Clinical predictors of streptococcal pharyngitis in adults. The Israel Medical Association Journal 5, 413-415. (Pubitemid 37107519)
6. Contreras, A., &, Slots, J., (1996) Mammalian viruses in human periodontitis. Oral Microbiology and Immunology 11, 381-386. (Pubitemid 27324648)
7. Cortellini, P., &, Tonetti, M., (2000) Focus on intrabony defects: guided tissue regeneration. Periodontology 2000 22, 104-132.
8. Cortellini, P., &, Tonetti, M. S., (2001) Microsurgical approach to periodontal regeneration. Initial evaluation in a case cohort. Journal of Periodontology 72, 559-569. (Pubitemid 33664502)
9. Cortellini, P., &, Tonetti, M. S., (2005) Clinical performance of a regenerative strategy for intrabony defects. Scientific evidence and clinical experience. Journal of Periodontology 76, 341-350. (Pubitemid 40668378)
10. Cortellini, P., &, Tonetti, M. S., (2007a) A minimally invasive surgical technique with an enamel matrix derivative in the regenerative treatment of intra-bony defects: a novel approach to limit morbidity. Journal of Clinical Periodontology 34, 87-93. (Pubitemid 44952524)
11. Cortellini, P., &, Tonetti, M. S., (2007b) Minimally invasive surgical technique and enamel matrix derivative in intra-bony defects. I: clinical outcomes and morbidity. Journal of Clinical Periodontology 34, 1082-1088.
12. Cortellini, P., Tonetti, M. S., Lang, N. P., Suvan, J. E., Zucchelli, G., Vangsted, T., Silvestri, M., Rossi, R., McClain, P., Fonzar, A., Dubravec, D., &, Adriaens, P., (2001) The simplified papilla preservation flap in the regenerative treatment of deep intrabony defects: clinical outcomes and postoperative morbidity. Journal of Periodontology 72, 1702-1712. (Pubitemid 34092736)
13. Darwazeh, A. M., Hammad, M. M., &, Al-Jamaei, A. A., (2010) The relationship between oral hygiene and oral colonization with Candida species in healthy adult subjects. International Journal of Dental Hygiene 8, 128-133.
14. Dawson, D. R. 3rd, Wang, C., Danaher, R. J., Lin, Y., Kryscio, R. J., Jacob, R. J., &, Miller, C. S., (2009) Salivary levels of Epstein-Barr virus DNA correlate with subgingival levels, not severity of periodontitis. Oral Diseases 15, 554-559.
15. Dewhirst, F. E., Chen, T., Izard, J., Paster, B. J., Tanner, A. C., Yu, W. H., Lakshmanan, A., &, Wade, W. G., (2010) The human oral microbiome. Journal of Bacteriology 192, 5002-5017.
16. Esposito, M., Grusovin, M. G., Papanikolaou, N., Coulthard, P., &, Worthington, H. V., (2009) Enamel matrix derivative (Emdogain) for periodontal tissue regeneration in intrabony defects. A Cochrane systematic review. European Journal of Oral Implantology 2, 247-266.
17. Fukui, K., Kato, N., Kato, H., Watanabe, K., &, Tatematsu, N., (1999) Incidence of Prevotella intermedia and Prevotella nigrescens carriage among family members with subclinical periodontal disease. Journal of Clinical Microbiology 37, 3141-3145. (Pubitemid 29455195)
18. Gmür, R., Wyss, C., Xue, Y., Thurnheer, T., &, Guggenheim, B., (2004) Gingival crevice microbiota from Chinese patients with gingivitis or necrotizing ulcerative gingivitis. European Journal of Oral Sciences 112, 33-41. (Pubitemid 38623862)
19. Grenier, G., Gagnon, G., &, Grenier, D., (2009) Detection of herpetic viruses in gingival crevicular fluid of patients suffering from periodontal diseases: prevalence and effect of treatment. Oral Microbiology and Immunology 24, 506-509.
20. Harrel, S. K., Wilson, T. G. Jr, &, Nunn, M. E., (2005) Prospective assessment of the use of enamel matrix proteins with minimally invasive surgery. Journal of Periodontology 76, 380-384. (Pubitemid 40668383)
21. Imbronito, A. V., Okuda, O. S., Maria de Freitas, N., Moreira Lotufo, R. F., &, Nunes, F. D., (2008) Detection of herpesviruses and periodontal pathogens in subgingival plaque of patients with chronic periodontitis, generalized aggressive periodontitis, or gingivitis. Journal of Periodontology 79, 2313-2321.
22. Linares, A., Cortellini, P., Lang, N. P., Suvan, J., &, Tonetti, M. S., (2006) Guided tissue regeneration/deproteinized bovine bone mineral or papilla preservation flap alone for treatment of intrabony defects. II: radiographic predictors and outcomes. Journal of Clinical Periodontology 33, 351-358. (Pubitemid 43549769)
23. Marsh, P. D., (2006) Dental diseases-are these examples of ecological catastrophes? International Journal of Dental Hygiene 4 (Suppl. 1), 3-10.
24. Mayfield, L., Tonetti, M. S., Cortellini, P., &, Lang, N. P., (2006) Microbial colonisation pattern predict the outcomes of surgical treatment of intrabony defects. Journal of Clinical Periodontology 33, 62-68. (Pubitemid 43423573)
25. Michalowicz, B. S., Ronderos, M., Camara-Silva, R., Contreras, A., &, Slots, J., (2000) Human herpesviruses and Porphyromonas gingivalis are associated with juvenile periodontitis. Journal of Periodontology 71, 981-988.
26. Murphy, K. G., &, Gunsolley, J. C., (2003) Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects. A systematic review. Annals of Periodontology 8, 266-302.
27. Nasi, M., Pinti, M., Manzini, S., Gibellini, L., Manzini, L., Bisi, L., De Biasi, S., Del Giovane, C., D'Amico, R., Borghi, V., Mussini, C., &, Cossarizza, A., (2010) Predictive value of intracellular HIV-1 DNA levels during CD4-guided treatment interruptions in HIV+ patients. AIDS Research and Human Retroviruses 26, 559-561.
28. Needleman, I. G., Worthington, H. V., Giedrys-Leeper, E., &, Tucker, R. J., (2006) Guided tissue regeneration for periodontal infra-bony defects. Cochrane Database Systematic Review 37, CD001724 Review.
29. Nibali, L., Atkinson, C., Griffiths, P., Darbar, U., Rakmanee, T., Suvan, J., &, Donos, N., (2009) Low prevalence of subgingival viruses in periodontitis patients. Journal of Clinical Periodontology 36, 928-932.
30. Nishihara, T., &, Koseki, T., (2004) Microbial etiology of periodontitis. Periodontology 2000 36, 14-26. (Pubitemid 41694986)
31. O'Sullivan, J. M., Cannon, R. D., Sullivan, P. A., &, Jenkinsonl, H. F., (1997) Identification of salivary basic proline-rich proteins as receptors for candida albicans adhesion. Microbiology 143, 341-348. (Pubitemid 27092169)
32. Paju, S., Pussinen, P. J., Suominen-Taipale, L., Hyvönen, M., Knuuttila, M., &, Könönen, E., (2009) Detection of multiple pathogenic species in saliva is associated with periodontal infection in adults. Journal of Clinical Microbiology 47, 235-238.
33. Pini Prato, G., Rotundo, R., Magnani, C., &, Ficarra, G., (2002) Viral etiology of gingival recession. A case report. Journal of Periodontology 73, 110-114. (Pubitemid 34213466)
34. Sakamoto, M., Umeda, M., &, Benno, Y., (2005) Molecular analysis of human oral microbiota. Journal of Periodontal Research 40, 277-285. (Pubitemid 40655856)
35. Saygun, I., Kubar, A., Özdemir, A., Yapar, M., &, Slots, J., (2004) Herpesviral-bacterial interrelationships in aggressive periodontitis. Journal of Periodontal Research 39, 207-212. (Pubitemid 38969602)
36. Saygun, I., Kubar, A., Sahin, S., Sener, K., &, Slots, J., (2008) Quantitative analysis of association between herpesviruses and bacterial pathogens in periodontitis. Journal of Periodontal Research 43, 352-359.
37. Slots, J., (2005) Herpesviruses in periodontal diseases. Periodontology 2000 38, 33-62. (Pubitemid 43034322)
38. Slots, J., (2007) Herpesviral-bacterial synergy in the pathogenesis of human periodontitis. Current Opinion in Infectious Diseases 20, 278-283. (Pubitemid 46686010)
39. Slots, J., (2010a) Human viruses in periodontitis. Periodontology 2000 53, 89-110.
40. Socransky, S. S., &, Haffajee, A. D., (1994) Evidence of bacterial etiology: a historical perspective. Periodontology 2000 5, 7-25.
41. Smith MacDonald, E., Nowzari, H., Contreras, A., Flynn, J., Morrison, J., &, Slots, J., (1998) Clinical and microbiological evaluation of a bioabsorbable and a nonresorbable barrier membrane in the treatment of periodontal intraosseous lesions. Journal of Periodontolology 69, 445-453. (Pubitemid 28259117)
42. Socransky, S. S., &, Haffajee, A. D., (2005) Microbiology of periodontal diseases: introduction. Periodontololgy 2000 38, 9-12. (Pubitemid 43034320)
43. Takemoto, T., Kurihara, H., &, Dahlen, G., (1997) Characterization of Bacteroides forsythus isolates. Journal of Clinical Microbiology 35, 1378-1381. (Pubitemid 27216798)
44. Tonetti, M., Cortellini, P., Lang, N. P., Suvan, J. E., Adriaens, P., Dubravek, D., Fonzar, A., Fourmousis, I., Rasperini, G., Rossi, R., Silvestri, M., Topoll, H., Wallkamm, B., &, Zybutz, M., (2004) Clinical outcomes following treatment of human intrabony defects with GTR/Bone replacement xenograft or access flap alone. A multicenter randomized controlled clinical trial. Journal of Clinical Periodontology 31, 770-776. (Pubitemid 39186432)
45. Tonetti, M. S., Cortellini, P., Suvan, J. E., Adraens, P., Baldi, C., Dubravek, D., Fonzar, A., Fourmousis, J., Magnani, C., Muller-Campanile, V., Patroni, S., Sanz, M., Vangsted, T., Zabalegui, I., Pini Prato, G., &, Lang, N. P., (1998) Generalizability of the added benefits of guided tissue regeneration in the treatment of deep intrabony defects. Evaluation in a multi-center randomized controlled clinical trial. Journal of Periodontology 69, 1183-1192. (Pubitemid 128519582)
46. Tonetti, M. S., Pini Prato, G. P., &, Cortellini, P., (1993) Periodontal regeneration of human infrabony defects. IV. Determinants of healing response. Journal of Periodontology 64, 934-940.
47. Tonetti, M. S., Pini Prato, G. P., &, Cortellini, P., (1995) Effect of cigarette smoking on on periodontal healing following GTR in infrabony defects. A preliminary retrospective study. Journal of Clinical Periodontology 22, 229-234.
48. Tonetti, M. S., Pini Prato, G. P., &, Cortellini, P., (1996) Factors affecting the healing response of intrabony defects following guided tissue regeneration and access flap surgery. Journal of Clinical Periodontology 23, 548-556. (Pubitemid 126731997)
49. Trombelli, L., Heitz-Mayfield, L. J., Needleman, I., Moles, D., &, Scabbia, A., (2002) A systematic review of graft materials and biological agents for periodontal intraosseous defects. Journal of Clinical Periodontology 29 (Suppl. 3), 117-135 discussion 160-162. (Pubitemid 41719447)
50. Tsitoura, E., Tucker, R., Suvan, J., Laurell, L., Cortellini, P., &, Tonetti, M., (2004) Baseline radiographic defect angle of the intrabony defect as a prognostic indicator in regenerative periodontal surgery with enamel matrix derivative. Journal of Clinical Periodontology 31, 643-647. (Pubitemid 39092227)
51. Umeda, M., Takeuchi, Y., Noguchi, K., Huang, Y., Koshy, G., &, Ishikawa, I., (2004) Effects of nonsurgical periodontal therapy on the microbiota. Periodontology 2000 36, 98-120. (Pubitemid 41694990)
52. Yapar, M., Saygun, I., Ozdemir, A., Kubar, A., &, Sahin, S., (2003) Prevalence of human herpesviruses in patients with aggressive periodontitis. Journal of Periodontology 74, 1634-1640. (Pubitemid 37540703)