Isolation and hypoglycemic activity of a novel pongamiaflavonylflavonol from pongamia pinnata pods

International Journal of Pharmacology

Volumn 8, Issue 4, 2012, Pages 265-270

  Semalty, A ^a   Semalty, M ^a   Kumar, P ^a   Mir, S R ^b   Ali, M ^b   Amin, S ^b  

^a H N B GARHWAL UNIVERSITY   (India)

^b HAMDARD UNIVERSITY   (India)

Author keywords

Antidiabetic; Hypoglycemic activity; Isolation; Novel flavonol; Phytoconstituent; Pongamia pinnata; Streptozotocin

Indexed keywords

ANTIDIABETIC AGENT; FLAVONOL DERIVATIVE; GLIBENCLAMIDE; GLUCOSE; PLANT EXTRACT; PONGAMIA PINNATA EXTRACT; PONGAMIAFLAVONYLFLAVONOL; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DETERMINATION; DRUG ISOLATION; GLUCOSE BLOOD LEVEL; NONHUMAN; PHYTOCHEMISTRY; PONGAMIA PINNATA; RAT; SPECTROSCOPY;

EID: 84859085718     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2012.265.270     Document Type: Article

References (18)

1. Ahmad, G., P.P. Yadav and R. Maurya, 2004. Furanoflavonoids glycosides from Pongamia pinnata. Phytochemistry, 65: 921-924.
2. American Diabetic Association, 2011. Diabetes statistics. Data from the 2011 National Diabetes Fact Sheet, http://www.diabetes.org/diabetes-basics/diabetes-statistics/
3. Badole, S.L. and S.L. Bodhankar, 2009a. Antihyperglycaemic activity of cycloart-23-ene-3β, 25-diol Isolated from stem bark of Pongamia pinnata in alloxan induced diabetic mice. Res. J. Phytochem., 3: 18-24.
4. Badole, S.L. and S.L. Bodhankar, 2009b. Concomitant administration of petroleum ether extract of the stem bark of Pongamia pinnata (L.) pierre with synthetic oral hypoglycaemic drugs in alloxan-induced diabetic mice. Eur. J. Integrative Med., 1: 73-79.
5. Bhyan, S.B., M.M. Alam and M.S. Ah, 2007. Effect of plant extracts on Okra mosaic virus incidence and yield related parameters of Okra. Asian J. Agric. Res., 1: 112-118.
6. Danmalam, U.H., L.M. Abdullahi, A. Agunu and K.Y. Musa, 2009. Acute toxicity studies and hypoglycemic activity of the methanol extract of the leaves of hyptis Suaveolens poit. (Lamiaceae). Nig. J. Pharm. Sci., 8: 87-92.
7. Inzucchi, S.E., 2002. Oral antihyperglycemic therapy for type 2 diabetes: Scientific review. J. Am. Med. Assoc, 287: 360-372.
8. Kanm, A., M.N. Sohail, S. Munir and S. Sattar, 2011. Pharmacology and phytochemistry of Pakistani herbs and herbal drugs used for treatement of diabetes. Int. J. Pharmacol, 7: 419-439.
9. Khare, C.P., 2004. Encyclopedia of Indian Medicinal Plants. Springer, New York, USA.
10. Kumar, P., A. Semalty, S.R. Mir, M. Ah and S. Amin, 2010. Hypoglycemic and hypolipidemic activity of Pongamia pinnata (Linn.) pierre in streptozotocin-induced diabetic rats. Int. J. Pharmacol., 6: 738-743.
11. Meera, B., S. Kumar and S.B. Kalidhar, 2003. A review of the chemistry and biological activity of Pongamia pinnata. J. Med. Arom. Plant Sci., 25: 441-465.
12. OECD., 1996. Guidelines for testing of chemicals. Test No. 4 25. http://www.oecd.Org/dataoecd/9/l1/33663321.pdf
13. Punitha, R., K. Vasudevan and S. Manoharan, 2006. Effect of Pongamia pinnata flowers on blood glucose and oxidative stress in alloxan induced diabetic rats. Indian J. Pharmacol., 38: 62-63.
14. Qureshi, S.J. and M.A. Khan, 2001. Ethnobotanical study of Kahuta from Rawalpindi District Pakistan. J. Biol. Sci., 1: 27-30.
15. Semalty, M. and A. Semalty, 2008. Hypoglycaemic activity of Ficus bengalensis in alloxan induced diabetes in albino rats. Indian Pharmacist, 7: 61-64.
16. Shirwaikar, A., S. Malini and S.C. Kumari, 2003. Protective effect of Pongamia pinnata flowers against cisplatin and gentamicin induced nephrotoxicity in rats. Indian J. Exp. Biol, 41: 58-62.
17. WHO, 2011. Facts and figures about diabetes. World Health Organization, Switzerland. http://www.who.int/diabetes/facts/en/
18. Wealth of India, 2003. A Dictionary of Raw Materials. CSIR, New Delhi, India, pp: 206-211.