Drosophila muscleblind codes for proteins with one and two tandem zinc finger motifs

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Irion, Uwe ^a  

^a MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHITIN SYNTHASE; CHITIN SYNTHASE 1; CORACLE PROTEIN; DROSOPHILA PROTEIN; MUSCLEBLIND PROTEIN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ISOPROTEIN; MUSCLEBLIND PROTEIN, DROSOPHILA; NUCLEAR PROTEIN; RNA;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL GENE; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; EPIDERMIS CELL; GENE FUNCTION; GENE LOCATION; GENE STRUCTURE; GENE TARGETING; IN VIVO STUDY; INSECT; MUSCLE; MUSCLEBLIND GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; SPECIES COMPARISON; TANDEM ZINC FINGER MOTIF; TISSUE SPECIFICITY; ZINC FINGER MOTIF; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; DROSOPHILA MELANOGASTER; GENE EXPRESSION REGULATION; GENETICS; INTRON; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN MOTIF;

CORA; HEXAPODA; INVERTEBRATA; VERTEBRATA;

ALTERNATIVE SPLICING; AMINO ACID MOTIFS; ANIMALS; BASE SEQUENCE; BINDING SITES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; INTRONS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN ISOFORMS; RNA; ZINC FINGERS;

EID: 84859066927     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034248     Document Type: Article

References (34)

1. Artero R, Prokop A, Paricio N, Begemann G, Pueyo I, et al. (1998) The muscleblind gene participates in the organization of Z-bands and epidermal attachments of Drosophila muscles and is regulated by Dmef2. Dev Biol 195: 131-143.
2. Begemann G, Paricio N, Artero R, Kiss I, Perez-Alonso M, et al. (1997) muscleblind, a gene required for photoreceptor differentiation in Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing proteins. Development 124: 4321-4331.
3. Ho TH, Charlet BN, Poulos MG, Singh G, Swanson MS, et al. (2004) Muscleblind proteins regulate alternative splicing. EMBO J 23: 3103-3112.
4. Machuca-Tzili L, Thorpe H, Robinson TE, Sewry C, Brook JD, (2006) Flies deficient in Muscleblind protein model features of myotonic dystrophy with altered splice forms of Z-band associated transcripts. Hum Genet 120: 487-499.
5. Vicente-Crespo M, Pascual M, Fernandez-Costa JM, Garcia-Lopez A, Monferrer L, et al. (2008) Drosophila muscleblind is involved in troponin T alternative splicing and apoptosis. PLoS One 3: e1613.
6. Miller JW, Urbinati CR, Teng-Umnuay P, Stenberg MG, Byrne BJ, et al. (2000) Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy. EMBO J 19: 4439-4448.
7. Cho DH, Tapscott SJ, (2007) Myotonic dystrophy: emerging mechanisms for DM1 and DM2. Biochim Biophys Acta 1772: 195-204.
8. Mooers BH, Logue JS, Berglund JA, (2005) The structural basis of myotonic dystrophy from the crystal structure of CUG repeats. Proc Natl Acad Sci U S A 102: 16626-16631.
9. Yuan Y, Compton SA, Sobczak K, Stenberg MG, Thornton CA, et al. (2007) Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs. Nucleic Acids Res 35: 5474-5486.
10. Charlet BN, Savkur RS, Singh G, Philips AV, Grice EA, et al. (2002) Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing. Mol Cell 10: 45-53.
11. Savkur RS, Philips AV, Cooper TA, (2001) Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy. Nat Genet 29: 40-47.
12. Du H, Cline MS, Osborne RJ, Tuttle DL, Clark TA, et al. (2010) Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy. Nat Struct Mol Biol 17: 187-193.
13. Osborne RJ, Thornton CA, (2006) RNA-dominant diseases. Hum Mol Genet 15 Spec No 2: R162-169.
14. Kanadia RN, Johnstone KA, Mankodi A, Lungu C, Thornton CA, et al. (2003) A muscleblind knockout model for myotonic dystrophy. Science 302: 1978-1980.
15. Mankodi A, Urbinati CR, Yuan QP, Moxley RT, Sansone V, et al. (2001) Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2. Hum Mol Genet 10: 2165-2170.
16. Adereth Y, Dammai V, Kose N, Li R, Hsu T, (2005) RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1. Nat Cell Biol 7: 1240-1247.
17. Kalsotra A, Xiao X, Ward AJ, Castle JC, Johnson JM, et al. (2008) A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc Natl Acad Sci U S A 105: 20333-20338.
18. Fernandez-Costa JM, Llamusi MB, Garcia-Lopez A, Artero R, (2011) Alternative splicing regulation by Muscleblind proteins: from development to disease. Biol Rev Camb Philos Soc pp. 947-958.
19. Goers ES, Purcell J, Voelker RB, Gates DP, Berglund JA, (2010) MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing. Nucleic Acids Res 38: 2467-2484.
20. Goers ES, Voelker RB, Gates DP, Berglund JA, (2008) RNA binding specificity of Drosophila muscleblind. Biochemistry 47: 7284-7294.
21. Sasagawa N, Ohno E, Kino Y, Watanabe Y, Ishiura S, (2009) Identification of Caenorhabditis elegans K02H8.1 (CeMBL), a functional ortholog of mammalian MBNL proteins. J Neurosci Res 87: 1090-1097.
22. Fernandez-Costa JM, Artero R, (2010) A conserved motif controls nuclear localization of Drosophila Muscleblind. Mol Cells 30: 65-70.
23. Tweedie S, Ashburner M, Falls K, Leyland P, McQuilton P, et al. (2009) FlyBase: enhancing Drosophila Gene Ontology annotations. Nucleic Acids Res 37: D555-559.
24. Monferrer L, Artero R, (2006) An interspecific functional complementation test in Drosophila for introductory genetics laboratory courses. J Hered 97: 67-73.
25. de Haro M, Al-Ramahi I, De Gouyon B, Ukani L, Rosa A, et al. (2006) MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1. Hum Mol Genet 15: 2138-2145.
26. Garcia-Lopez A, Monferrer L, Garcia-Alcover I, Vicente-Crespo M, Alvarez-Abril MC, et al. (2008) Genetic and chemical modifiers of a CUG toxicity model in Drosophila. PLoS One 3: e1595.
27. Burnette JM, Miyamoto-Sato E, Schaub MA, Conklin J, Lopez AJ, (2005) Subdivision of large introns in Drosophila by recursive splicing at nonexonic elements. Genetics 170: 661-674.
28. Ward JJ, McGuffin LJ, Bryson K, Buxton BF, Jones DT, (2004) The DISOPRED server for the prediction of protein disorder. Bioinformatics 20: 2138-2139.
29. Grammatikakis I, Goo YH, Echeverria GV, Cooper TA, (2011) Identification of MBNL1 and MBNL3 domains required for splicing activation and repression. Nucleic Acids Res 39: 2769-2780.
30. Benoist P, Mas JA, Marco R, Cervera M, (1998) Differential muscle-type expression of the Drosophila troponin T gene. A 3-base pair microexon is involved in visceral and adult hypodermic muscle specification. J Biol Chem 273: 7538-7546.
31. Fehon RG, Dawson IA, Artavanis-Tsakonas S, (1994) A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. Development 120: 545-557.
32. Beall CJ, Fyrberg E, (1991) Muscle abnormalities in Drosophila melanogaster heldup mutants are caused by missing or aberrant troponin-I isoforms. J Cell Biol 114: 941-951.
33. Qiu F, Brendel S, Cunha PM, Astola N, Song B, et al. (2005) Myofilin, a protein in the thick filaments of insect muscle. J Cell Sci 118: 1527-1536.
34. Ostrowski S, Dierick HA, Bejsovec A, (2002) Genetic control of cuticle formation during embryonic development of Drosophila melanogaster. Genetics 161: 171-182.