A conserved motif controls nuclear localization of Drosophila Muscleblind

Molecules and Cells

Volumn 30, Issue 1, 2010, Pages 65-70

  Fernandez Costa, Juan M ^a   Artero, Ruben ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

alternative splicing factor; KRAEK motif; muscleblind; myotonic dystrophy; nuclear localization signal

Indexed keywords

COMPLEMENTARY DNA; MUSCLE PROTEIN; MUSCLEBLIND LIKE PROTEIN; RNA; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL STRAIN COS1; CELLULAR DISTRIBUTION; DROSOPHILA; HUMAN; MUTATION; MYOTONIC DYSTROPHY; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PLASMID; PROTEIN LOCALIZATION; PROTEIN MOTIF;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; CELL NUCLEUS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CONSERVED SEQUENCE; COS CELLS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN ISOFORMS; SUBCELLULAR FRACTIONS; TRANSFECTION; ZINC FINGERS;

EID: 77955026115     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10059-010-0089-9     Document Type: Article

References (25)

1. Y. Adereth V. Dammai N. Kose R. Li T. Hsu 2005 RNAdependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1 Nat. Cell Biol. 7 1240 1247 10.1038/ncb1335 16273094 (Pubitemid 41741737)
2. R. Carmona D. Macias J.A. Guadix V. Portillo J.M. Perez-Pomares R. Munoz-Chapuli 2007 A simple technique of image analysis for specific nuclear immunolocalization of proteins J. Microsc. 225 96 99 10.1111/j.1365-2818.2007. 01719.x 1:CAS:528:DC%2BD2sXjs1Wltrc%3D 17286699 (Pubitemid 46213664)
3. W.M. Chan P.C. Shaw H.Y. Chan 2007 A green fluorescent protein-based reporter for protein nuclear import studies in Drosophila cells Fly 1 340 342 18820439
4. J.M. Fernandes J.R. Kinghorn I.A. Johnston 2007 Characterization of two paralogous muscleblind-like genes from the tiger pufferfish (Takifugu rubripes) Comp. Biochem. Physiol. B Biochem. Mol. Biol. 146 180 186 10.1016/j.cbpb.2006. 10.100 17157048 (Pubitemid 46201917)
5. M.C. Frith N.F. Saunders B. Kobe T.L. Bailey 2008 Discovering sequence motifs with arbitrary insertions and deletions PLoS Comput. Biol. 4 e1000071 10.1371/journal.pcbi.1000071 18437229 (Pubitemid 351811555)
6. E.S. Goers R.B. Voelker D.P. Gates J.A. Berglund 2008 RNA binding specificity of Drosophila muscleblind Biochemistry 47 7284 7294 10.1021/bi702252d 1:CAS:528:DC%2BD1cXnt1Cmurk%3D 18557632 (Pubitemid 351956377)
7. T.H. Ho B.N. Charlet M.G. Poulos G. Singh M.S. Swanson T.A. Cooper 2004 Muscleblind proteins regulate alternative splicing EMBO J. 23 3103 3112 10.1038/sj.emboj.7600300 1:CAS:528:DC%2BD2cXmt1Wqu7w%3D 15257297 (Pubitemid 39093604)
8. J.M. Houseley Z. Wang G.J. Brock J. Soloway R. Artero M. Perez-Alonso K.M. O'Dell D.G. Monckton 2005 Myotonic dystrophy associated expanded CUG repeat muscle-blind positive ribonuclear foci are not toxic to Drosophila Hum. Mol. Genet. 14 873 883 10.1093/hmg/ddi080 1:CAS:528:DC%2BD2MXitVCmsrY%3D 15703191 (Pubitemid 40403282)
9. A. Kalsotra X. Xiao A.J. Ward J.C. Castle J.M. Johnson C.B. Burge T.A. Cooper 2008 A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart Proc. Natl. Acad. Sci. USA 105 20333 20338 10.1073/pnas.0809045105 1:CAS:528:DC%2BD1MXhsFWlsQ%3D%3D 19075228
10. R.N. Kanadia K.A. Johnstone A. Mankodi C. Lungu C.A. Thornton D. Esson A.M. Timmers W.W. Hauswirth M.S. Swanson 2003 A muscleblind knockout model for myotonic dystrophy Science 302 1978 1980 10.1126/science.1088583 1:CAS:528:DC%2BD3sXps1amsLo%3D 14671308 (Pubitemid 37523508)
11. R.N. Kanadia J. Shin Y. Yuan S.G. Beattie T.M. Wheeler C.A. Thornton M.S. Swanson 2006 Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy Proc. Natl. Acad. Sci. USA 103 11748 11753 10.1073/pnas.0604970103 1:CAS:528: DC%2BD28XotFagt7o%3D 16864772 (Pubitemid 44182522)
12. L.B. Li Z. Yu X. Teng N.M. Bonini 2008 RNA toxicity is a component of ataxin-3 degeneration in Drosophila Nature 453 1107 1111 10.1038/nature06909 1:CAS:528:DC%2BD1cXntlGjtLw%3D 18449188 (Pubitemid 351871727)
13. X. Lin J.W. Miller A. Mankodi R.N. Kanadia Y. Yuan R.T. Moxley M.S. Swanson C.A. Thornton 2006 Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy Hum. Mol. Genet. 15 2087 2097 10.1093/hmg/ddl132 1:CAS:528:DC%2BD28XmtFKgu70%3D 16717059 (Pubitemid 43923398)
14. L. Monferrer R. Artero 2006 An interspecific functional complementation test in Drosophila for introductory genetics laboratory courses J. Hered. 97 67 73 10.1093/jhered/esj003 1:CAS:528:DC%2BD28XhtFahsL4%3D 16394256 (Pubitemid 43214175)
15. M. Mutsuddi C.M. Marshall K.A. Benzow M.D. Koob I. Rebay 2004 The spinocerebellar ataxia 8 noncoding RNA causes neurodegeneration and associates with staufen in Drosophila Curr. Biol. 14 302 308 1:CAS:528:DC%2BD2cXhsFWrur8%3D 14972680
16. J.C. Obenauer L.C. Cantley M.B. Yaffe 2003 Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs Nucleic Acids Res. 31 3635 3641 10.1093/nar/gkg584 1:CAS:528:DC%2BD3sXltVWju74%3D 12824383 (Pubitemid 37442212)
17. M. Pascual M. Vicente L. Monferrer R. Artero 2006 The Muscleblind family of proteins: an emerging class of regulators of developmentally programmed alternative splicing Differentiation 74 65 80 10.1111/j.1432-0436.2006.00060.x 1:CAS:528:DC%2BD28XjsVCmsbw%3D 16533306 (Pubitemid 43376167)
18. D.D. Rudnicki S.E. Holmes M.W. Lin C.A. Thornton C.A. Ross R.L. Margolis 2007 Huntington's disease-like 2 is associated with CUG repeat-containing RNA foci Ann. Neurol. 61 272 282 10.1002/ana.21081 1:CAS:528:DC%2BD2sXkvFykurc%3D 17387722 (Pubitemid 46557351)
19. B.E. Sisson S.L. Ziegenhorn R.A. Holmgren 2006 Regulation of Ci and Su(fu) nuclear import in Drosophila Dev. Biol. 294 258 270 10.1016/j.ydbio.2006. 02.050 1:CAS:528:DC%2BD28XksVOmsb8%3D 16595130
20. M. Teplova D.J. Patel 2008 Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1 Nat. Struct. Mol. Biol. 15 1343 1351 10.1038/nsmb.1519 1:CAS:528:DC%2BD1cXhsVenu7zO 19043415
21. M. Vicente L. Monferrer M.G. Poulos J. Houseley D.G. Monckton K. O'Dell M. O'Dell M.S. Swanson R.D. Artero 2007 Muscleblind isoforms are functionally distinct and regulate alpha-actinin splicing Differentiation 75 427 440 10.1111/j.1432-0436.2006.00156.x 1:CAS:528:DC%2BD2sXmsFemtb8%3D 17309604 (Pubitemid 46802159)
22. M. Vicente-Crespo M. Pascual J.M. Fernandez-Costa A. Garcia-Lopez L. Monferrer M.E. Miranda L. Zhou R.D. Artero 2008 Drosophila muscleblind is involved in troponin T alternative splicing and apoptosis PloS one 3 e1613 10.1371/journal.pone.0001613 18286170 (Pubitemid 351850769)
23. M.B. Warf J.A. Berglund 2007 MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its premRNA substrate cardiac troponin T RNA 13 2238 2251 10.1261/rna.610607 1:CAS:528:DC%2BD2sXhsVWitL7M 17942744 (Pubitemid 350127564)
24. Y. Yuan S.A. Compton K. Sobczak M.G. Stenberg C.A. Thornton J.D. Griffith M.S. Swanson 2007 Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs Nucleic Acids Res. 35 5474 5486 10.1093/nar/gkm601 1:CAS:528:DC%2BD2sXht1ygtb%2FO 17702765 (Pubitemid 47423921)
25. L. Zhou G. Jiang G. Chan C.P. Santos D.W. Severson L. Xiao 2005 Michelob-x is the missing inhibitor of apoptosis protein antagonist in mosquito genomes EMBO Rep. 6 769 774 10.1038/sj.embor.7400473 1:CAS:528: DC%2BD2MXmvVGgsr0%3D 16041319 (Pubitemid 43108700)