Insect neuropeptide bursicon homodimers induce innate immune and stress genes during molting by activating the NF-κB transcription factor relish

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  An, Shiheng ^a   Dong, Shengzhang ^a   Wang, Qian ^a   Li, Sheng ^b   Gilbert, Lawrence I ^c   Stanley, David ^d   Song, Qisheng ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b INSTITUTE OF PLANT PHYSIOLOGY AND ECOLOGY   (China)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BURSICON; DROSOPHILA PROTEIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 2; HOMODIMER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEUROPEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELISH; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; HORMONE; RELISH PROTEIN, DROSOPHILA;

ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; GENE EXPRESSION; GENE EXPRESSION REGULATION; IMMUNE DEFICIENCY; INNATE IMMUNITY; LARVA; MOLTING; NEUROMODULATION; NONHUMAN; TRANSCRIPTION INITIATION; UPREGULATION; ANIMAL; DIMERIZATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; METABOLISM;

BACTERIA (MICROORGANISMS); DROSOPHILA MELANOGASTER; HEXAPODA;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; DIMERIZATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; IMMUNITY, INNATE; INVERTEBRATE HORMONES; LARVA; MOLTING; TRANSCRIPTION FACTORS;

EID: 84859049128     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034510     Document Type: Article

References (22)

1. Riddiford LM, Cherbas P, Truman JW, (2000) Ecdysone receptors and their biological actions. Vitam Horm 60: 1-73.
2. Honegger HW, Deway EM, Ewer J, (2008) Bursicon, the tanning hormone of insects: recent advances following the discovery of its molecular identity. J Comp Physiol A 194: 989-1005.
3. Song Q, (2012) Bursicon, a neuropeptide hormone that controls cuticle tanning and wing expansion. In: Gilbert LI, editors. Insect Endocrinology Academic Press, San Diego, CA pp. 93-105.
4. Luo CW, Dewey EM, Sudo S, Ewer J, Hsu SY, et al. (2005) Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2. Proc Natl Acad Sci USA 102: 2820-2825.
5. Mendive FM, Loy TV, Claeysen S, Poels J, Williamson M, et al. (2005) Drosophila molting neurohormone bursicon is a heterodimer and the natural agonist of the orphan receptor DLGR2. FEBS Lett 579: 2171-2176.
6. Baker J, Truman JW, (2002) Mutations in the Drosophila glycoprotein hormone receptor, rickets, eliminate neuropeptide-induced tanning and selectively block a stereotyped behavioral program. J Exp Biol 205: 2555-2565.
7. Dewey EM, McNabb SL, Ewer J, Kuo GR, Takanishi CL, et al. (2004) Identification of the gene encoding bursicon, an insect neuropeptide responsible for cuticle sclerotization and wing spreading. Curr Biol 14: 1208-1213.
8. Davis MM, O'Keefe SL, Primrose DA, Hodgetts RB, (2007) A neuropeptide hormone cascade controls the precise onset of post-eclosion cuticular tanning in Drosophila melanogaster. Development 134: 4395-4404.
9. Arakane Y, Li B, Muthukrishnan S, Beeman RW, Kramer KJ, et al. (2008) Functional analysis of four neuropeptides, EH, ETH, CCAP and bursicon, and their receptors in adult ecdysis behavior of the red flour beetle, Tribolium castaneum. Mech Dev 125: 984-995.
10. Bai H, Palli SR, (2010) Functional characterization of bursicon receptor and genome-wide analysis for identification of genes affected by bursicon receptor RNAi. Dev Biol 344: 248-258.
11. Huang J, Zhang Y, Li M, Wang S, Liu W, et al. (2007) RNA interference-mediated silencing of the bursicon gene induces defects in wing expansion of silkworm. FEBS Lett 581: 697-701.
12. Kimura K, Kodama A, Hayasaka Y, Ohta T, (2004) Activation of the cAMP/PKA signaling pathway is required for post-ecdysial cell death in wing epidermal cells of Drosophila melanogaster. Development 131: 1597-1606.
13. Loveall BJ, Deitcher DL, (2010) The essential role of bursicon during Drosophila development. BMC Development 10: 92-108.
14. Wang S, An S, Song Q, (2008) Transcriptional expression of bursicon and novel bursicon-regulated genes in the house fly Musca domestica. Arch Insect Biochem Physiol 68: 100-112.
15. An S, Wang S, Gilbert L, Beerntsen B, Ellersieck M, et al. (2008) Global identification of bursicon-regulated genes in Drosophila melanogaster. BMC Genomics 9: 424.
16. Lemaitre B, Hoffmann J, (2007) The host defense of Drosophila melanogaster. Annu Rev Immunol 25: 697-743.
17. Lemaitre B, Kromer-Metzger E, Michaut L, Nicolas E, Meister M, et al. (1995) A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense. Proc Natl Acad Sci USA 92: 9465-9469.
18. Stöven S, Silverman N, Junell A, Hedengren-Olcott M, Erturk D, et al. (2003) Caspase-mediated processing of the Drosophila NF-kB factor Relish. Proc Natl Acad Sci USA 100: 5991-5996.
19. Sternberg EM, (2006) Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens. Nat Rev Immunol 6: 318-328.
20. Tracey KJ, (2011) Ancient neurons regulate immunity. Science 332: 673-674.
21. Ekengren S, Hultmark D, (2001) A family of turandot-related genes in the humoral stress response of Drosophila. Biochem Biophys Res Comm 284: 998-1003.
22. Ekengren S, Tryselius Y, Dushay MS, Liu G, Steiner H, et al. (2001) A humoral stress response in Drosophila. Curr Biol 11: 714-718.