Development of methods for studying the differentiation of human mesenchymal stem cells under cyclic compressive strain

Tissue Engineering - Part C: Methods

Volumn 18, Issue 4, 2012, Pages 252-262

  Michalopoulos, Efstathios ^a   Knight, Richard L ^a   Korossis, Sotirios ^a   Kearney, John N ^b   Fisher, John ^a   Ingham, Eileen ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; ANTIBODIES; CLONING; CYTOLOGY; POLYMERASE CHAIN REACTION; STEM CELLS;

BINDING FACTORS; CELL ASSAYS; CELL NUMBER; COMPRESSIVE STRAIN; DIFFERENTIATED CELLS; EMBRYONIC STEM CELLS; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN MESENCHYMAL STEM CELLS; MULTIPLE CELLS; OSTEOGENIC; QUANTITATIVE REAL-TIME POLYMERASE CHAIN REACTION; TISSUE ENGINEERING APPLICATIONS;

SCAFFOLDS (BIOLOGY);

AGGRECAN; ALGINIC ACID; COLLAGEN; GLUCURONIC ACID; HEXURONIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SOX9 PROTEIN, HUMAN; TISSUE SCAFFOLD; TRANSCRIPTION FACTOR SOX9;

AGED; ANIMAL; ARTICLE; BIOMECHANICS; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMISTRY; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MECHANICAL STRESS; MESENCHYMAL STEM CELL; METABOLISM; METHODOLOGY; MIDDLE AGED; PHENOTYPE; RAT; REAL TIME POLYMERASE CHAIN REACTION;

AGED; AGGRECANS; ALGINATES; ANIMALS; BIOMECHANICS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; COLLAGEN; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; MESENCHYMAL STEM CELLS; MIDDLE AGED; PHENOTYPE; PPAR GAMMA; RATS; REAL-TIME POLYMERASE CHAIN REACTION; SOX9 TRANSCRIPTION FACTOR; STRESS, MECHANICAL; TISSUE SCAFFOLDS;

EID: 84859047954     PISSN: 19373384     EISSN: 19373392     Source Type: Journal    
DOI: 10.1089/ten.tec.2011.0347     Document Type: Article

References (33)

1. Pittenger, M.F., Mackay, A.M., Beck, S.C. et al. Multi-lineage potential of adult human mesenchymal stem cells. Science 284, 143, 1999.
2. Jiang, Y., Jahagirdar, B.N. Reinhardt, R.L. et al. Pluripotency of mesenchymal stem cells derived from adult marrows. Nature 418, 41, 2002.
3. Pasini, A., Krampera, M., Rigo, A. et al. HB-EGF/HER-1 signalling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multi-lineage differentiation. Blood 106, 59, 2005.
4. Pauwels, F. A new theory concerning the influence of mechanical stimuli in the differentiation of supporting tissues. Biomech Locomotor Apparatus 375, 458, 1980.
5. Liu, S.Q. Influence of tensile strain on smooth muscle cell orientation in rat blood vessels. J Biomech Eng 120, 313, 1998.
6. Buschmann, M.D., Gluzband, Y.A., Grodzinsky, A.J. et al. Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture. J Cell Sc 108, 1497, 1995.
7. Takagaki, Y.M. Mechanical responses and signal transduction pathways in stretched osteocytes. J Bone Miner Metab 17, 57, 1999.
8. Jen, C.J., Jhiang, S.J., and Chen, H.I. Cellular responses to mechanical stress: effects of flow on vascular endothelial intracellular calcium signaling of rat aortas ex vivo. J Appl Physiol 89, 1657, 2000.
9. Katsumi, A., Orr, A.W., Tzima, E. et al. Integrins in mechanotransduction. J Biolog Chem 279, 12001, 2004.
10. Neidlinger-Wilke, C., Grood, E.S., Wang, J.H.C. et al. Cell alignment is induced by cyclic changes in cell length: studies of cells grown in cyclically stretched substrates. J Orthop Res 19, 286, 2001.
11. Simmons, C.A., Matlis, S., Thornton, A.J. et al. Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomechan 36, 1087, 2003.
12. Altman, G., Horan, R., Martin, I. et al. Cell differentiation by mechanical stress. FASEB J 16, 270, 2002.
13. Wakitani, S., Saito, T., and Caplan, A.I. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 18, 1417, 1995.
14. Woodbury, D., Schwarz, E.J., Prockop, D.J. et al. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 61, 364, 2000.
15. Jones, E.A., Kinsey, S.E., English, A. et al. Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. Arthritis Rheum 46, 3349, 2002.
16. Korossis, S., Booth, C., Wilcox, H.E., Ingham, E. Kearney, J.N., Watterson, K.G., and Fisher, J. Tissue engineering a cardiac valve prosthesis II: biomechanical characterisation of decellularised porcine heart valves. J Heart Valve Dis 11, 463, 2002.
17. Matthews, J.B., Mitchell, W., Stone, M.H., Fisher, J., and Ingham, E. A novel three-dimensional tissue equivalent model to study the combined effects of cyclic mechanical strain and wear particles on the osteolytic potential of primary human macrophages in vitro. Proc Inst Mech Eng H 215H, 479, 2001.
18. Lodie, T.A., Blickarz, C.E., Devarakonda, T.J. et al. Systematic analysis of reportedly distinct populations of multipotent bone marrow-derived stem cells reveals a lack of distinction. Tissue Eng 8, 739, 2002.
19. De Boer, J., Siddappa, R., Gaspar, C. et al. Wnt signalling inhibits osteogenic differentiation of human mesenchymal stem cells. Bone 34, 818, 2004.
20. Colter, D.C., Sekiya I., and Prockop, D.J. Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells. Proc Natl Acad Sci 98, 7841, 2001.
21. Dennis, J.E., Carbillet, J.P., Caplan, A.I., and Charbord, P. The STRO-1 + marrow cell population is multipotential. Cells Tissues Organs 170, 73, 2002.
22. Ignatius, A., Blessing, H., Liedert, A. et al. Tissue engineering of bone: effects of mechanical strain on osteoblastic cells in type I collagen matrices. Biomaterials 26, 311, 2005.
23. Ma, P.X., and Zhang, R.Y. Synthetic nano-scale fibrous extracellular matrix. J Biomed Materl Res 46, 60, 1999.
24. Cummings, C.L., Gawlitta, D.N., Robert, M. et al. Properties of engineered vascular constructs made from collagen, fibrin and collagen-fibrin mixtures. Biomaterials 25, 3699, 2004.
25. Young, R.G., Butler, D.L., Weber, W. et al. Use of mesenchymal stem cells in a collagen matrix for Achilles tendon repair. J of Orthop Res 16, 406, 1998.
26. Wei, S., Yang, D., Wang, D., Phimphilai, M., Krebsbach, P.H., and Franceschi, R. T. In vitro and in vivo synergistic interactions between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation. J Bone Miner Res 18, 705, 2003.
27. Barak, Y., Nelson, M.C., Ong, E.S., Jones, Y.Z., Ruiz-Lozano, P., Chien, K.R., Koder, A., and Evans, R.M. PPAR gamma is required for placental, cardiac and adipose tissue development. Mol Cell 4, 585, 1999.
28. Lefebvre, V., Behringer, R.R., and de Crombrugghe, B. LSox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway. Osteoarthritis Cartilage 9, S69, 2001.
29. Takahashi, I. Nuckolls, G.H., Takahashi, K., Tanaka, O., Semba, I. Dashner, R., Shum L., and Slavkin, H. C. Compressive force promotes Sox9, type II collagen and aggrecan and inhibits IL-1 beta expression resulting in chondrogenesis in mouse embryonic limb bud mesenchymal cells. J Cell Sci 111, 2067, 1998.
30. Huang, C.Y, Hagar, K.L, Frost, L.E, Sun, Y., and Cheung, H.S. Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells. Stem Cells 22, 313, 2004.
31. Campbell, J.J., Lee, D.A., and Bader, D.L. Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cells. Biorheology 43, 455, 2006.
32. Sumanasinghe, R.D., Bernacki, S.H., and Loboa, E.G. Osteogenic differentiation of human mesenchymal stem cells in collagen matrices: effect of uniaxial cyclic tensile strain on bone morphogenetic protein (BMP-2) mRNA expression. Tissue Eng 12, 3459, 2006.
33. Silver, F.H., Siperko, L.M., and Seehra, G.P. Mechanobiology of force transduction in dermal tissue. Skin Res Technol 9, 3, 2003.