A novel three-dimensional tissue equivalent model to study the combined effects of cyclic mechanical strain and wear particles on the osteolytic potential of primary human macrophages in vitro

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

Volumn 215, Issue 5, 2001, Pages 479-486

  Matthews, J B ^a   Mitchell, W ^a   Stone, M H ^b   Fisher, J ^a   Ingham, E ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b LEEDS GENERAL INFIRMARY   (United Kingdom)

Author keywords

Biologic response; Cyclic strain; Cytokines; In vitro; Wear particles

Indexed keywords

ADENOSINETRIPHOSPHATE; POLYETHYLENES; STRAIN; TISSUE; WEAR OF MATERIALS; CELLS; CYTOLOGY; MACROPHAGES; PHYSIOLOGY;

CYCLIC STRAIN; CYTOKINES;

BACTERIOPHAGES; TISSUE ENGINEERING;

BIOLOGIC RESPONSE; CYCLIC STRAIN; CYTOKINES; IN-VITRO; WEAR PARTICLES;

AUTACOID; TUMOR NECROSIS FACTOR;

ARTICLE; BIOLOGICAL MODEL; BIOSYNTHESIS; COCULTURE; HUMAN; MACROPHAGE; MACROPHAGE ACTIVATION; MATERIALS TESTING; OSTEOLYSIS; PHYSIOLOGY;

COCULTURE; HUMAN; INFLAMMATION MEDIATORS; MACROPHAGE ACTIVATION; MACROPHAGES; MATERIALS TESTING; MODELS, BIOLOGICAL; OSTEOLYSIS; SUPPORT, NON-U.S. GOV'T; TUMOR NECROSIS FACTOR;

EID: 0035226419     PISSN: 09544119     EISSN: None     Source Type: Journal    
DOI: 10.1243/0954411011536073     Document Type: Conference Paper

References (33)

1. The pathology of total joint arthroplasty. II. Mechanisms of implant failure
2. Editorial: The problem in total joint arthroplasty: Aseptic loosening
3. Materials selection and design in orthopaedic implants with improved long-term performance
4. Production of novel cytokines with bone-resorbing properties by peri-prosthetic tissues
5. Assessment of the role of GM-csf in the cellular transformation and the development of erosive lesions around orthopaedic implants
6. Polyethylene particles of a 'critical size' are necessary for the induction of cytokines by macrophages in vitro
7. Comparison of the response of primary human peripheral blood mononuclear phagocytes from different donors to challenge with polyethylene particles of known size and dose
8. The response of primary human peripheral blood mononuclear phagocytes to challenge with in vitro generated clinically relevant UHMWPE particles of known size and dose
9. Wear of high-density polyethylene sockets in total hip arthroplasty and its role in endosteal cavitation
10. Histologic, biochemical and ion analysis of tissue and fluids retrieved during total hip arthroplasty
11. Does early micromotion of the femoral stem prosthesis matter - 4-7 year stereoradiographic follow-up of 84 cemented prostheses
12. Localised endosteal bone lysis in relation to the femoral components of cemented total hip arthroplasties
13. Pressure modulates monocyte migration
14. Short periods of oscillating fluid pressure directed at a titanium-bone interface in rabbits leads to bone lysis
15. Fluid pressure enhances osteoclastic bone resorption
16. Fluid pressure may cause periprosthetic osteolysis: Particles are not the only thing
17. The effect of cyclic pressure on human monocytederived macrophages in vitro
18. Cyclic pressure and particles are synergistic in human macrophage activation
19. Biomechanical regulation of human monocyte/macrophage molecular function
20. Repetitive mechanical strain suppresses macrophage uptake of immunoglobulin G complexes and enhances cyclic adenosine monophosphate synthesis
21. Increased applied pressure enhances the uptake of IgG complexes by macrophages
22. Periprosthetic bone resorption. Particles versus movement
23. The effects of micromotion and particulate materials on tissue differentiation. Bone chamber studies in rabbits
24. Intermittent micromotion and polyethylene particles inhibit bone ingrowth into titanium chambers in rabbits
25. Timing of loading and effect of micro-motion on bone-dental implant interface: Review of experimental literature
26. Bone cell physiology
27. Role of cytokines in the regulation of bone resorption
28. Role of tumour necrosis factor in particulate induced bone resorption
29. Influence of TNF-alpha in polystyrene particle stimulated macrophage bone resorption
30. Quantitation and experimental design: Cell counting
31. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
32. The enzyme linked immunosorbent assay (ELISA)