Epigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Hanoun, Maher ^a   Eisele, Lewin ^a   Suzuki, Masako ^c   Greally, John M ^c   Hüttmann, Andreas ^a   Aydin, Semra ^a   Scholtysik, René ^b   Klein Hitpass, Ludger ^b   Dührsen, Ulrich ^a   Dürig, Jan ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; CRYPTOCHROME 1; IMMUNOGLOBULIN HEAVY CHAIN; MESSENGER RNA; CRY1 PROTEIN, HUMAN; CRYPTOCHROME;

ACUTE LYMPHOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CANCER PATIENT; CHRONIC LYMPHATIC LEUKEMIA; CIRCADIAN RHYTHM; COHORT ANALYSIS; CONTROLLED STUDY; CPG ISLAND; CRY1 GENE; DISEASE COURSE; DNA DETERMINATION; DNA METHYLATION; FEMALE; GENE; GENE EXPRESSION; GENE SILENCING; GENETIC ASSOCIATION; GENETIC REGULATION; GENETIC TRANSCRIPTION; HIGH RISK PATIENT; HUMAN; HUMAN CELL; LEUKEMIA CELL; MAJOR CLINICAL STUDY; MALE; MODULATION; OUTCOME ASSESSMENT; PROGNOSIS; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; GENETIC EPIGENESIS; GENETICS; IMMUNOGLOBULIN HEAVY CHAIN GENE; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; MORTALITY; PATHOLOGY;

MAMMALIA;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD38; CIRCADIAN CLOCKS; CPG ISLANDS; CRYPTOCHROMES; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENE SILENCING; GENES, IMMUNOGLOBULIN HEAVY CHAIN; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC;

EID: 84859015067     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034347     Document Type: Article

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