Asthma phenotypes: Consistency of classification using induced sputum

Respirology

Volumn 17, Issue 3, 2012, Pages 461-466

  Hancox, Robert J ^a   Cowan, Douglas C ^a   Aldridge, Ruth E ^c   Cowan, Jan O ^a   Palmay, Rochelle ^a   Williamson, Avis ^a   Town, G Ian ^b   Taylor, D Robin ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF CANTERBURY   (New Zealand)

^c DERBY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

eosinophil; neutrophil; non eosinophilic asthma

Indexed keywords

BECLOMETASONE; BRONCHODILATING AGENT; BUDESONIDE; FLUTICASONE; IPRATROPIUM BROMIDE; PLACEBO; SALBUTAMOL; TERBUTALINE;

ADOLESCENT; ADULT; AGED; ARTICLE; ASTHMA; CLINICAL ASSESSMENT; CLINICAL CLASSIFICATION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG MEGADOSE; EOSINOPHIL; FEMALE; GENETIC STABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL COUNT; PHENOTYPE; PRIORITY JOURNAL; SPUTUM ANALYSIS;

ADULT; ANTI-ASTHMATIC AGENTS; ASTHMA; BUDESONIDE; EOSINOPHILIA; EOSINOPHILS; FEMALE; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; SPUTUM; TERBUTALINE; YOUNG ADULT;

EID: 84859010641     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2011.02113.x     Document Type: Article

References (18)

1. Wenzel SE,. Asthma: defining of the persistent adult phenotypes. Lancet 2006; 368: 804-13.
2. Pavord I, Brightling C, Woltmann G, et al,. Non-eosinophilc corticosteroid unresponsive asthma. Lancet 1999; 15: 2213-4.
3. Green RH, Brightling CE, Woltmann G, et al,. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002; 57: 875-9.
4. Berry M, Morgan A, Shaw DE, et al,. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax 2007; 62: 1043-9.
5. Cowan DC, Cowan JO, Palmay R, et al,. The effects of steroid therapy on inflammatory cell subtypes in asthma. Thorax 2010; 65: 384-90.
6. Fahy JV,. Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc. Am. Thorac. Soc. 2009; 6: 256-9.
7. Reddel HK, Taylor DR, Bateman ED, et al,. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am. J. Respir. Crit. Care Med. 2009; 180: 59-99.
8. Aldridge RE, Hancox RJ, Robin Taylor D, et al,. Effects or terbutaline and budesonide on sputum cells and bronchial hyperresponsiveness in asthma. Am. J. Respir. Crit. Care Med. 2000; 161: 1459-64.
9. Simpson JL, Scott R, Boyle MJ, et al,. Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology 2006; 11: 54-61.
10. Simpson JL, McElduff P, Gibson PG,. Assessment and reproducibility of non-eosinophilic asthma using induced sputum. Respiration 2010; 79: 147-51.
11. van Veen IH, ten Brinke A, Gauw SA, et al,. Consistency of sputum eosinophilia in difficult-to-treat asthma: A 5-year follow-up study. J. Allergy Clin. Immunol. 2009; 124: 615-7.e2.
12. D'Silva L, Cook RJ, Allen CJ, et al,. Changing pattern of sputum cell counts during successive exacerbations of airway disease. Respir. Med. 2007; 101: 2217-20.
13. D'Silva L, Allen CJ, Hargreave FE, et al,. Sputum neutrophilia can mask eosinophilic bronchitis during exacerbations. Can. Respir. J. 2007; 14: 281-4.
14. Cowan DC, Cowan JO, Palmay R, et al,. Simvastatin in the treatment of asthma: lack of steroid-sparing effect. Thorax 2010; 65: 891-6.
15. Green RH, Brightling CE, McKenna S, et al,. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 2002; 360: 1715-21.
16. Jayaram L, Pizzichini MM, Cook RJ, et al,. Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. Eur. Respir. J. 2006; 27: 483-94.
17. Godon P, Boulet LP, Malo JL, et al,. Assessment and evaluation of symptomatic steroid-naive asthmatics without sputum eosinophilia and their response to inhaled corticosteroids. Eur. Respir. J. 2002; 20: 1364-9.
18. Wallace J, D'Silva L, Brannan J, et al,. Association between proximity to major roads and sputum cell counts. Can. Respir. J. 2011; 18: 13-8.