Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation

Cancer Science

Volumn 103, Issue 4, 2012, Pages 782-790

  Kondo, Yuudai ^a   Nagai, Kentaro ^a   Nakahata, Shingo ^a   Saito, Yusuke ^a   Ichikawa, Tomonaga ^a   Suekane, Akira ^a   Taki, Tomohiko ^b   Iwakawa, Reika ^c   Enari, Masato ^c   Taniwaki, Masafumi ^b   Yokota, Jun ^c   Sakoda, Sumio ^a   Morishita, Kazuhiro ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ABSENT IN MELANOMA 2 PROTEIN; DOUBLE STRANDED DNA; INTERFERON INDUCIBLE 16 PROTEIN; NUCLEAR PROTEIN; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOSOME; B LYMPHOCYTE ACTIVATION; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CHROMOSOME 1Q23; CONTROLLED STUDY; GENE AMPLIFICATION; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE MAPPING; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; INNATE IMMUNITY; MOUTH CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, HUMAN, PAIR 1; GENE AMPLIFICATION; GENES, P53; HUMANS; MOUTH NEOPLASMS; NF-KAPPA B; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; TRANSCRIPTION FACTOR AP-1;

EID: 84859007742     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2012.02211.x     Document Type: Article

References (28)

1. Shah JP, Singh B. Keynote comment: why the lack of progress for oral cancer? Lancet Oncol 2006; 7: 356-7.
2. Gibson MK, Forastiere AA. Reassessment of the role of induction chemotherapy for head and neck cancer. Lancet Oncol 2006; 7: 565-74.
3. Perez-Sayans M, Somoza-Martin JM, Barros-Angueira F, Reboiras-Lopez MD, Gandara Rey JM, Garcia-Garcia A. Genetic and molecular alterations associated with oral squamous cell cancer (Review). Oncol Rep 2009; 22: 1277-82.
4. Rogers SJ, Harrington KJ, Rhys-Evans P, P OC, Eccles SA. Biological significance of c-erbB family oncogenes in head and neck cancer. Cancer Metastasis Rev 2005; 24: 47-69.
5. Rousseau A, Lim MS, Lin Z, Jordan RC. Frequent cyclin D1 gene amplification and protein overexpression in oral epithelial dysplasias. Oral Oncol 2001; 37: 268-75.
6. Reed AL, Califano J, Cairns P et al. High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res 1996; 56: 3630-3.
7. Choi S, Myers JN. Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy. J Dent Res 2008; 87: 14-32.
8. Sisk EA, Soltys SG, Zhu S, Fisher SG, Carey TE, Bradford CR. Human papillomavirus and p53 mutational status as prognostic factors in head and neck carcinoma. Head Neck 2002; 24: 841-9.
9. Min BM, Baek JH, Shin KH, Gujuluva CN, Cherrick HM, Park NH. Inactivation of the p53 gene by either mutation or HPV infection is extremely frequent in human oral squamous cell carcinoma cell lines. Eur J Cancer B Oral Oncol 1994; 30B: 338-45.
10. Boyer SN, Wazer DE, Band V. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res 1996; 56: 4620-4.
11. Feller L, Wood NH, Khammissa RA, Lemmer J. Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: human papillomavirus-mediated carcinogenesis. Head Face Med 2010; 6: 14.
12. Unterholzner L, Keating SE, Baran M et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 2010; 11: 997-1004.
13. Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 2009; 458: 509-13.
14. Asefa B, Klarmann KD, Copeland NG, Gilbert DJ, Jenkins NA, Keller JR. The interferon-inducible p200 family of proteins: a perspective on their roles in cell cycle regulation and differentiation. Blood Cells Mol Dis 2004; 32: 155-67.
15. Ludlow LE, Johnstone RW, Clarke CJ. The HIN-200 family: more than interferon-inducible genes? Exp Cell Res 2005; 308: 1-17.
16. Liao JC, Lam R, Brazda V et al. Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53. Structure 2011; 19: 418-29.
17. Chen IF, Ou-Yang F, Hung JY et al. AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. Mol Cancer Ther 2006; 5: 1-7.
18. Toruner GA, Ulger C, Alkan M et al. Association between gene expression profile and tumor invasion in oral squamous cell carcinoma. Cancer Genet Cytogenet 2004; 154: 27-35.
19. Zhong LP, Zhao SF, Chen GF, Ping FY, Xu ZF, Hu JA. Increased levels of CK19 mRNA in oral squamous cell carcinoma tissue detected by relative quantification with real-time polymerase chain reaction. Arch Oral Biol 2006; 51: 1112-9.
20. Ding YM, Dong JH, Chen LL, Zhang HD. Increased expression of galectin-1 is associated with human oral squamous cell carcinoma development. Oncol Rep 2009; 21: 983-7.
21. Azzimonti B, Pagano M, Mondini M et al. Altered patterns of the interferon-inducible gene IFI16 expression in head and neck squamous cell carcinoma: immunohistochemical study including correlation with retinoblastoma protein, human papillomavirus infection and proliferation index. Histopathology 2004; 45: 560-72.
22. Martin-Ezquerra G, Salgado R, Toll A et al. Multiple genetic copy number alterations in oral squamous cell carcinoma: study of MYC, TP53, CCDN1, EGFR and ERBB2 status in primary and metastatic tumours. Br J Dermatol 2010; 163: 1028-35.
23. Kawauchi K, Araki K, Tobiume K, Tanaka N. p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat Cell Biol 2008; 10: 611-8.
24. Takahashi T, Takahashi T, Suzuki H et al. The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern. Oncogene 1991; 6: 1775-8.
25. Fujiuchi N, Aglipay JA, Ohtsuka T et al. Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. J Biol Chem 2004; 279: 20339-44.
26. Chi LM, Lee CW, Chang KP et al. Enhanced interferon signaling pathway in oral cancer revealed by quantitative proteome analysis of microdissected specimens using 16O/18O labeling and integrated two-dimensional LC-ESI-MALDI tandem MS. Mol Cell Proteomics 2009; 8: 1453-74.
27. Chen C, Mendez E, Houck J et al. Gene expression profiling identifies genes predictive of oral squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 2008; 17: 2152-62.
28. Song LL, Alimirah F, Panchanathan R, Xin H, Choubey D. Expression of an IFN-inducible cellular senescence gene, IFI16, is up-regulated by p53. Mol Cancer Res 2008; 6: 1732-41.