Nicotine modifies in vivo and in vitro rat hippocampal amyloid precursor protein processing in young but not old rats

Neuroscience Letters

Volumn 514, Issue 1, 2012, Pages 22-26

  Scerri, Charles ^a   Stewart, Caroline A ^a   Balfour, David J K ^a   Breen, Kieran C ^a,b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b Institute of Neurology   (United Kingdom)

Author keywords

Age; Alzheimer's disease; Amyloid precursor protein; Hippocampus; Nicotine

Indexed keywords

AMYLOID PRECURSOR PROTEIN; MECAMYLAMINE; NICOTINE;

AGE; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CORTEX; BRAIN SLICE; CONTROLLED STUDY; CORPUS STRIATUM; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; RAT;

AGE FACTORS; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CORPUS STRIATUM; HIPPOCAMPUS; MALE; MECAMYLAMINE; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84859007700     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.02.042     Document Type: Article

References (30)

1. Avila A.M., Davila-Garcia M.I., Ascarrunz V.S., Xiao Y., Kellar K.J. Differential regulation of nicotinic acetylcholine receptors in PC12 cells by nicotine and nerve growth factor. Mol. Pharmacol. 2003, 64:974-986.
2. Benwell M.E.M., Balfour D.J.K., Birrell C.E. Desensitization of the nicotine-induced mesolimbic dopamine responses during constant infusion with nicotine. Br. J. Pharmacol. 1995, 114:454-460.
3. Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
4. Breen K.C., Coughlan C.M., Hayes F.D. The role of glycoproteins in neural development function and disease. Mol. Neurobiol. 1998, 16:163-220.
5. Caillé I., Allinquant B., Dupont E., Bouillot C., Langer A., Müller U., Prochiantz A. Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development 2004, 131:2173-2181.
6. Efthimiopoulos S., Vassilacopoulou D., Ripellino J.A., Tezapsidis N., Robakis N.K. Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:8046-8050.
7. German D.C., Eisch A.J. Mouse models of Alzheimer's disease: insight into treatment. Rev. Neurosci. 2004, 15:353-369.
8. Gutala R., Wang J., Hwang Y.Y., Haq R., Li M.D. Nicotine modulates expression of amyloid precursor protein and amyloid precursor-like protein 2 in mouse brain and in SH-SY5Y neuroblastoma cells. Brain Res. 2006, 1093:12-19.
9. Hodges H., Allen Y., Sinden J. Effects of cholinergic-rich neural grafts on radial maze performance of rats after excitotoxic lesions of the forebrain cholinergic projection system-II. Cholinergic drugs as probes to investigate lesion-induced deficits and transplant-induced functional recovery. Neuroscience 1991, 45:609-623.
10. Jin K., Galvan V., Xie L., Mao X.O., Gorostiza O.F., Bredesen D.E., Greenberg D.A. Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:13363-13367.
11. Kim S.H., Kim Y.K., Jeong S.J., Haass C., Kim Y.H., Suh Y.H. Enhanced release of secreted form of Alzheimer's amyloid precursor protein from PC12 cells by nicotine. Mol. Pharmacol. 1997, 52:430-436.
12. Kuhn H.G., Dickonson-Anson H., Gage F.H. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 1996, 16:2027-2033.
13. Lahiri D.K., Utsuki T., Chen D., Farlow M.R., Shoaib M., Ingram D.K., Greig N.H. Nicotine reduces the secretion of Alzheimer's beta-amyloid precursor protein containing beta-amyloid peptide in the rat without altering synaptic proteins. Ann. N. Y. Acad. Sci. 2002, 965:364-372.
14. Lenzken S.C., Lanni C., Govani S., Lucchelli A., Schettini G., Racchi M. Nicotinic component of galantamine in the regulation of amyloid precursor protein processing. Chem. Biol. Interact. 2007, 165:138-145.
15. Li Y., Papke R.L., He Y.-J., Millard W.J., Meyer E.M. Characterization of the neuroprotective and toxic effects of α7 nicotinic receptor activation in PC12 cells. Brain Res. 1999, 830:218-225.
16. Liu Q., Zhang J., Zhu H., Qin C., Chen Q., Zhao B. Dissecting the signalling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model. FASEB 2007, 21:61-73.
17. McLaughlin M., Breen K.C. Protein kinase C activation potentiates the rapid secretion of the amyloid precursor protein from rat cortical synaptosomes. J. Neurochem. 1999, 72:273-281.
18. Mousavi M., Hellström-Lindahl E. Nicotinic receptor agonists and antagonists increase sAPPα secretion and decrease Aβ levels in vitro. Neurochem. Int. 2009, 54:237-244.
19. Mousavi M., Hellström-Lindahl E., Guan Z.-Z., Shan K.-R., Ravid R., Nordberg A. Protein and mRNA level of nicotinic receptors in brain of tobacco using controls and patients with Alzheimer's disease. Neuroscience 2003, 122:515-520.
20. Pastorino L., Lu K.P. Pathogenic mechanisms in Alzheimer's disease. Eur. J. Pharmacol. 2006, 545:29-38.
21. Perry D.C., Davila-Garcia M.I., Stockmeier C.A., Kellar K.J. Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies. J. Pharmacol. Exp. Ther. 1999, 289:1545-1552.
22. Picciotto M.R., Zoli M. Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Front. Biosci. 2008, 13:492-504.
23. Roberson M.R., Harrell L.E. Cholinergic activity and amyloid precursor protein metabolism. Brain Res. Rev. 1997, 25:50-69.
24. Scerri C., Stewart C.A., Breen K.C., Balfour D.J.K. The effects of chronic nicotine on spatial learning and bromodeoxyuridine incorporation in the dentate gyrus of the rat. Psychopharmacology (Berl.) 2006, 184:540-546.
25. Seo J., Kim S., Kim H., Park C.H., Joeng S., Lee J., Choi S.H., Chang K., Rah J., Koo J., Kim E., Suh Y. Effects of nicotine on APP secretion and Abeta- or CT(105)-induced toxicity. Biol. Psychiatry 2001, 49:240-247.
26. Shimohama S., Greenwald D.L., Shafron D.H., Akaika A., Maeda T., Kaneko S., Kimura J., Simpkins C.E., Day A.L., Meyer E.M., Nicotinic α7 Receptors protect against glutamate neurotoxicity and neuronal ischemic damage. Brain Res. 1998, 779:359-363.
27. Srivareerat M., Tran T.T., Salim S., Aleisa A.M., Alkadhi K.A. Chronic nicotine restores normal Aβ levels and prevents short-term memory and E-LTP impairment in Aβ rat model of Alzheimer's disease. Neurobiol. Aging 2011, 32:834-844.
28. Thornton E., Vink R., Blumbergs P.C., Van Den Heuvel C. Soluble amyloid precursor protein α reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury. Brain Res. 2006, 1094:38-46.
29. Turner P.R., O'Connor K., Tate W.P., Abraham W.C. Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog. Neurobiol. 2003, 70:1-32.
30. Zhang C., McNeil E., Dressler L., Siman R. Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease. Exp. Neurol. 2007, 204:77-87.