Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro

Toxicology

Volumn 294, Issue 2-3, 2012, Pages 80-84

  Seeger, T ^a   Eichhorn, M ^b   Lindner, M ^b   Niessen, K V ^a   Tattersall, J E H ^c   Timperley, C M ^c   Bird, M ^c   Green, A C ^c   Thiermann, H ^a   Worek, F ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^b Asklepios Clinic   (Germany)

^c DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

Acetylcholinesterase; Human intercostal muscle; Neuromuscular function; Organophosphorus compound

Indexed keywords

ANTIDOTE; MB 327; NICOTINIC RECEPTOR; SOMAN; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; BREATHING MUSCLE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIAPHRAGM MUSCLE; DRUG EFFECT; DRUG SCREENING; ELECTROSTIMULATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INTERCOSTAL MUSCLE; MALE; MUSCLE FORCE; NEUROMUSCULAR DISEASE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

AGED; ANIMALS; ANTIDOTES; CHEMICAL WARFARE AGENTS; DIAPHRAGM; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INTERCOSTAL MUSCLES; MALE; MIDDLE AGED; PYRIDINIUM COMPOUNDS; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; RESPIRATORY MUSCLES; SOMAN; SPECIES SPECIFICITY;

CAVIA; RATTUS;

EID: 84859006523     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.02.002     Document Type: Article

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